Publication list Dr.
Sven Gohla
Book chapters:
1. Gohla,
S.H., Soltau, H., Schrum, S., Haubeck, H., Neth, R.D., Immunmoulation am
Beispiel der Cupressaceae „Thuja occidentalis L.“, In: Albrecht, H., Franz, G.:
Naturheilverfahren, 56-83, 1988
2. Neth,
R.D., Gallo, R.C., Greaves, M.F., Gaedicke, G., Gohla, S.H., Mannweiler, K.,
Ritter, J., (Eds.), Modern Trends in Human Leukemia VIII, 268-272, Springer
Verlag, ISBN 3-540-50967-4, 1989
3. Gohla, S.H., Zeman, R.A., Bögel, M.,
Jurkiewicz, E., Schrum, S., Haubeck, H.D., Schmitz, H., Hunsmann, G., Neth,
R.D., Modification of the in vitro replication of the Human Immunodeficiency
virus HIV-1 by TPSg, a polysaccharide fraction isolated from the cupressaceae
Thuja occidentalis L. (arborvitae), in: Neth, R. et al. (Eds.),
Modern Trends in Human Leukemia IX, Springer Verlag, 140-149, ISBN
3-540-54360-0, 1992
4. Schneider,
G., Gohla, S.H., Kaden, W., Schönrock, U, Schmidt-Lewerkühne, H., Kuschel, A.,
Pape, W., Skin Cosmetics, In: Ullmann´s Encyclopedia of Industrial Chemistry
A24, 219-245, 1993
5. Gohla,
S.H., Multiple Emulsionen vom Typ Wasser-inÖl-in-Wasser (W/O/W) in Kosmetika,
In: Müller, R.H., Hildebrand, G.E., Pharmazeutische Technologie: Moderne
Arzneiformen, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, 195-206,
1997
6. Gohla,
S.H., Multiple emulsions in cosmetics, In: Müller, R.H., Benita, S., Böhm, B.:
Emulsions and Nanosuspensions for the the formulation of poorly soluble drugs,
Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, 67-78, 1998
7.
Gohla, S.H., Nielsen,
J., Partial Phase-Soluinversion technology (PPSIT), a novel process to
manufacture long term stable multiple emulsions by an in situ one step
procedure, In: Ziolkowsky, H., „Emulsions“, Technology, structures, ingredients
& formulations, Verlag für chemische Industrie 34-44, 1998, ISBN
3-87846-196-8
8.
Müller, R. H., Dingler, A., Schneppe, T., Gohla, S.,
Large scale production of solid lipid nanoparticles (SLNTM) and nanosuspensions
(DissoCubesTM), in: Handbook of Pharmaceutical Controlled Release Technology
(Wise, D., ed.), 359-376, 2000
9.
Müller, R. H., Lippacher, A., Gohla, S., Solid Lipid
Nanoparticles (SLNâ) as Carrier
System for the Controlled Release of Drugs, in: Handbook of Pharmaceutical
Controlled Release Technology (Wise, D., ed.), 377-391, 2000
10. Müller,
R. H., Souto, E. B., Göppert, T., Gohla, S., Production of biofunctionalized
solid lipid nanoparticles (SLN) for site-specific drug delivery, in:
Nanotechnologies for the Life Science (C. Kumar, ed.), 287-303, 2006
Patents:
1.
Gohla, S.H., Haubeck, H.D., Neth, R.D., Pharmaceutical
composition containing polysaccharides extracted from Thuja plants to modulate
human T-helper lymphocytes, EP 315182, 1986
2.
Gohla, S.H., Neth, R.D., Reski, R., Schrum, S.,
Isolation of Thuja-fractions comprising extracted and precipitated
polysaccharides and proteins, DE 19505795, 1992
3. Gohla, S. H., Nielsen, J., Kröpcke,
R., Dahms, G., Stabile multiple Emulsionen vom Typ WOW, WO 92/18227, 1992
4.
Gohla, S.H., Heinze, F., Thamssen, G., Nielsen J.,
Moisturizing and cooling cosemtic and pharmaceutical composition based on
substances with positive dissolution enthalpy, such as Xylitol, WO 9423688,
1993
5. Gohla, S. H., Müller, A., Nielsen, J.,
WOW-Emulsionen, EP 0 735 853 B1, 1994
6.
Doerschner A., Ennen, J., Gohla, S.H., Kaden, W., Kielholz,
J., Lanzendörfer G., Nielsen, J., Sauermann, G., Untiedt, S., Use of
polysaccharides e.g. hyaluronic acid, chitosan etc. in cosmetic and
dermatological preparations to provide protection against skin irritations, EP
937454, 1995
7. Klier, M, Wolf, F., Gohla, S.H., Gegen
unreine Haut und milde Formen der Akne wirksame Zubereitung mit einem Gehalt an
Wollwachssäure, DE 43 29 379, 1995
8. Schreiber, J., Klier, M., Wolf, F.,
Eitrich, A., Gohla, S.H., Kosmetische oder dermatologische Mikroemulsionen, DE
195 09 079 A1, 1996
9.
Gohla, S.H., Riedel, J., Wolf, F, Use of combinations
of uricase and uric acid in cosmetic and dermatological preparations useful for
skin-moisturizing, skin or hair bleaching or treatment of acne, psioriasis or
dermatitis, JP 09175991, 1996
10. Gohla,
S.H., Klier, M., Meiring, U., Traupe, B., Wolf, F., Combatting
propionibacterium acnes, spots and acne by fatty acid mono glycerides, DE
4337711,1996
11. Gohla,
S.H., Klier, M., Wolf, F, Skin and acne treatment composition comprising of
mixtures of lanolin acid, WO 9506457, 1996
12. Gohla,
S.H., Kaden, W., Kielholz, J., Kruse, U., Meiring, U., Nielsen, J., Stäb, F.,
Wolf, F., Cosmetic or dermatological compositions containing oligomers or
polymers of alpha-hydroxycarboxylic acid, WO 96/38125, 1996
13. Gers-Barlag,
H., Gohla, S.H., Müller, A., Nielsen, J., Stable oil-in-water-in-oil emulsions
for cosmetic and pharmaceutical use – comprise of emulsifiers with pH – and/or
temperature-dpendent lipophilicity, EP 780112 A1, 1997
14. Müller,
A., Nielsen, J., Gohla, S. H., Water-in-Oil-in-Water emulsions, US-Patent
5,750,124, 1998
15. Gohla,
S.H., Kaden, W., Kielholz, J., Kruse, U., Meiring, U., Nielsen, J., Staeb, F.,
Wolf, F., Klier, M, Non-irritating cosmetic or dermatological preparation
containing (co)polymer-or oligomer of alpha hydroxy carboxylic acid as source
of corresponding monomers, WO 9638125, 1998
16. Diec,
K.H., Gers-Barlag, H., Klier, M., Schreiber, J., Wolf, F., Eitrich, A., Gohla,
S.H., Cosemtic or pharmaceutical microemulsion gel containing oil in water
emulsifiers with oxyalkylene groups and thickeners with hydrophobic groups and
hydrophilic regions bridging droplets, WO 9628132,1998
Refereed papers:
1.
Gohla, S.H.,
Haubeck, H.D., Neth, R.D., Mitogenic activity of high molecular polysaccharide
fractions from the cupressaceae Thuja occidentalis L., I. Macrophage-dependent
induction of CD4 + T-helper lymphocytes, Leukemia 2 (8), 528-533, 1988
2.
Gohla, S.H.,
Haubeck, H.D., Schrum S., Soltau, H, Neth, R.D., Activation of CD4-positive
T-cells by polysaccharide fraction isolated from the cupressaceae Thuja
occidentalis L. (arborvitae), Hämatolologie & Bluttransfusion 32, 268-272,
1989
3. Gohla, S.H., Zeman, R.A., Gartner, S.,
Popovic, M., Jurkiewicz, E., Haubeck, H.D., Schrum, S., Gallo, R.C., Neth,
R.D., Hunsmann, G., Inhibition of HIV-1 and reverse transcriptase by TPSg, a
hihgh molecular plysaccharide fraction derived from the Cupressaceae Thuja
Occidentalis L., AIDS Res. Human Retroviruses 6 (1), 131-143, 1990
4. Gan, O.I., Drize, N.I., Gohla, S.H.,
Schrum, S., Neth, R.D., Action of a polysaccharide from Thuja-occidentalis L.
on stromal precursor cells of the hematopoietic microenvironment in mice, Bull.
Exp. Biology Medicine 112 (12), 635-637, 1991
5. Offergeld,
R., Reinecker, C., Gumz, E. Neth, R.D., Sadovnikova, E., Schrum, S., Gohla,
S.H., TPSg, a biological response modifier, Ann. Meet. Aids Res.
Humanretroviruses 8 (5), 911-913, 1992
6.
Offergeld, R.,
Reinecker, C., Gumz, E., Schrum, S., Treiber, R., Neth, R.D., Gohla, S.H.,
Mitogenic activity of high molecular polysaccharide fractions isolated from the
cupressaceae Thuja occidentalis L. II. Enhnaced cytokine-production by thujapolysaccharide,
g-fraction (TPSg), Leukemia 6 (Suppl. 3), 189S-191S, 1992
7.
Neth, R.D., Gan,
O., Sadovnikova, E., Gohla, S.H., Gumz, E., Schrum, S., Drize, N.,
Radioprotection of haemtopoietic and stromal precursors by polysacharide
fractions isolated from the cupressaceae Thuja occidentalis L., Ann. Meet. Aids
Res. Humanretroviruses 8 (5), 625-630, 1992
8.
Schneider, G.,
Gohla, S.H., Kaden W., Schönrock, U., Schmidt-Lewerkühne H., Kuschel, A., Pape,
W., Ippen, H., Skin Cosmetics, In: Ullmann´s Encyclopedia of Industrial
Chemistry, 219-245, 1993
9. Neth,
R.D., Drize, N., Gohla, S.H., Offergeld, R., Reski, R. Schrum, S.,
Phytotherapeutische Forschung: Thuja occidentlais L., Zeitschrift für
Allgemeinmedizin 71/7, 522-530, 1995
10. Schrum, S., Neth, R.D., Gohla, S.H.,
Reski, R., Specific induction of CD4 + T-cells by a polysaccharides-fraction of
TPSg, Aids Res. Human Retroviruses Vol. 11 (1), 159-168, 1995
11. Gohla S. H., Nielsen J., Partial Phase
Solu-Inversion technology (PPSIT), A novel procedure to manufacture long term
stable multiple emulsions by an in situ one step procedure, SÖFW, 121, 707-713,
1995
12. Hassan, H.T., Drize, N.J., Sadovnikova,
E.Y., Gan, O.I., Gohla, S.H., Schrum, S., Neth, R.D., TPSg, an anti human
immunodeficiency virus (HIV-1) agent, isolated from the cupressaceae Thuja
occidentalis L. enhances in vivo hemopoietic progentor cell recovery in
sublethally irradiated mice, Immunol. Letters 50(1-2), 119-122, 1996
13. Dingler,
A., Blum, R. P., Niehus, H., Gohla, S., Müller, R. H., Solid lipid
nanoparticles (SLNTM/LipopearlsTM) - A pharmaceutical and cosmetic carrier for
the application of vitamin E in dermal products, Journal of Microencapsulation
16 (6), 751-767, 1999
14. Müller,
R. H., Mäder, K., Gohla, S., Solid lipid nanoparticles (SLN) for controlled
drug delivery – a review of the state of the art, Eur. J. Pharm. Biopharm. 50, 161-177, 2000
15. Souto,
E. B.,
16. Souto,
E. B.,
Non-refereed papers:
1.
Müller, R. H., Souto, E. B., Gohla, S., Lipid
nanoparticles (Nanopearls): A novel cosmetic carrier, SÖFW Journal 9, 36-45,
2004
2.
Müller, R. H.,
3.
Müller, R. H., Souto, E. B., Gohla, S., Nanopearls –
the novel carrier system for cosmetic application, Eurocosmetics 3, 22-26, 2005
Proceedings:
1. Dingler,
A., Hildebrand, G.E., Kielholz, J., Pfeiffer, S., Debus, N., Müller, R.H.,
Gohla, S., Electron and fluorescence micrographical characterisation of
lipopearls™ (SLN™), Int. Symp.
Control. Rel. Bioact. Mater. 24, 925-926, 1997
2. Dingler,
A., Lukowski, G., Pflegel, P., Müller, R.H., Gohla, S., Production and characterisation
of lipopearls™ for cosmetics, Int. Symp.
Control. Rel. Bioact. Mater. 24, 935-936, 1997
3.
Dingler, A., Lukowski, G., Pflegel, P., Gohla, S.,
Müller, R.H., Production of solid lipid nanoparticles (SLNTM) from cosmetic
lipids and surfactants, 2nd World Congress on Emulsion,
4.
Dingler, A., Lukowski, G., Gohla, S., Müller, R.H.,
Production and characterisation of solid lipid nanoparticles as colloidal
carrier system for cosmetic products, 2nd World Congress on Emulsion,
5.
Dingler, A., Hildebrand, G.E., Kielholz, J., Gohla,
S., Müller, R.H., Fluorescence and electron microscopic characterisation of
solid lipid nanoarticles n aqueous dispersions and ointments, 2nd World
Congress on Emulsion, Bodeaux, 4-2-297, 1997
6.
Müller, R.H., Gohla, S., Hildebrand, G.,
7. Müller,
R.H., Dingler, A., Hildebrand, G.E., Gohla, S., Development of Cosmetic
Products (Lipopearls™) based on Solid Lipid Nanoparticles, Int. Symp. Control. Rel. Bioact. Mater. 25,
238-239, 1998
8.
Dingler, A., Müller, R.H., Gohla, S., Incorporation of
Hydrophilic Active Ingredients in Solid Lipid Nanoparticles for the Topical
Application, 2nd World Meeting on Pharmaceutics, Biopharmaceutics and
Pharmaceutical Technology APGI/APV, Paris, 625-626, 1998
9.
Jenning, V., Gohla S., Müller R.H., Solid Lipid Nanoparticles
(SLN): Effect of homogenization parameters on drug stability, 2nd World Meeting
on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV,
10. Jenning,
V., Hildebrand, G. E., Gysler, A., Schäfer-Korting, M., Gohla, S., Solid lipid
nanoparticles (SLNTM) for topical application: occlusive properties, Int. Symp. Control. Rel. Bioact. Mater. 26,
405-406, 1999
Abstracts:
1. Dingler,
A., Krohs, S., Lukowski, G., Gohla, S., Müller, R.H., SLN (Solid Lipid
Nanoparticles) as new solid carrier of active ingredients in cosmetics, Eur. J.
Pharm. Sci. 4, S148, 1996