Publication list Prof. R.H. Müller

 

(Total Publications: 1241)

 

 

 

Patents/Patent applications:          21 (not listed)

 

Books:                                           19

 

Book chapters:                              70

 

Refereed papers:                          293

 

Non-refereed papers:                     57

 

Proceedings:                               291

 

Abstracts:                                    490

 

 

 

 

Books:

 

(1)   Müller, R. H., Colloidal Carriers for Controlled Drug Delivery and Targeting - Modification, Characterization and in vivo Distribution, Wissenschaftliche Verlagsgesellschaft Stuttgart, CRC Press Boca Raton, 379 S., 1991

 

(2)   Müller, R. H., Zetapotential und Partikelladung in der Laborpraxis – Einführung in die Theorie, praktische Meßdurchführung, Dateninterpretation, Wissenschaftliche Verlagsgesellschaft Stuttgart, 254 S.,1996

 

(3)   Müller, R. H., Schuhmann, R., Teilchengrößenmessung in der Laborpraxis, Wissenschaftliche Verlagsgesellschaft Stuttgart, 191 S., 1996

 

(4)   Müller, R. H., Hildebrand, G. E. (Hrsg), Pharmazeutische Technologie: Moderne Arzneiformen, Lehrbuch für Studierende der Pharmazie - Nachschlagewerk für Apotheker in Offizin, Krankenhaus und Forschung, Wissenschaftliche Verlagsgesellschaft Stuttgart, 1. Aufl., 348 S., 1997

 

(5)   Müller, R. H., Mehnert, W. (Hrsg), Particle and Surface Characterisation Methods, Wissenschaftliche Verlagsgesellschaft Stuttgart, 280 S., 1997

 

(6)   Müller, R. H., Hildebrand, G. E. (Hrsg), Pharmazeutische Technologie: Moderne Arzneiformen, Lehrbuch für Studierende der Pharmazie - Nachschlagewerk für Apotheker in Offizin, Krankenhaus und Forschung, Wissenschaftliche Verlagsgesellschaft Stuttgart, 2. erweiterte Aufl., 471 S., 1998

 

(7)   Diederichs, J. E., Müller, R. H. (Hrsg), Future Strategies for Drug Delivery with Particulate Systems, Wissenschaftliche Verlagsgesellschaft Stuttgart, 194 S., 1998

 

(8)   Müller, R. H., Hildebrand, G. E., Jachowicz, R., Kubis, A., Klawe, J. (Hrsg), Technologia nowoczesnych postaci leków, Wydawnictwo Lekarskie PZWL Warschau, 356 S., 1998

 

(9)   Müller, R. H., Benita, S., Böhm, B. (Hrsg), Emulsions and Nanosuspensions for the Formulation of Poorly Soluble Drugs, medpharm Scientific Publishers Stuttgart, 396 S., 1998

 

(10) Müller, R. H., Schneppe, T., Qualitätsmanagement und Validierung in der pharmazeutischen Praxis, Editio Cantor Verlag Aulendorf, 182 S., 1999

 

(11) Zabka, M., Müller, R. H., Hildebrand, G. E. (Hrsg), Moderné lieky vo farmaceutickej technológii, slovakische Übersetzung des Lehrbuchs „Pharmazeutische Technologie: Moderne Arzneiformen“, Slovak Academic Press Bratislava, 487 S., 1999

 

(12) Kayser, O., Müller, R. H. (Hrsg), Pharmazeutische Biotechnologie. Ein Kompendium für Forschung und Praxis, Wissenschaftliche Verlagsgesellschaft, Stuttgart, 2000

 

(13) Zabka, M., Müller, R. H., Hildebrand, G. E. (Hrsg), Moderní lékové formy ve farmaceutické technologii, tschechische Übersetzung des Lehrbuchs „Pharmazeutische Technologie: Moderne Arzneiformen“, Slovak Academic Press Bratislava, 486 S., 2001

 

(14) Müller, R. H., Böhm, B. (Hrsg), Dispersion Techniques for Laboratory and Industrial Scale Processing, Wissenschaftliche Verlagsgesellschaft Stuttgart, 113 S., 2001

 

(15) Müller, R. H., Schneppe, T., Qualitätsmanagement und Validierung in der pharmazeutischen Praxis, Editio Cantor Verlag Aulendorf, 2. erweiterte Aufl., 218 S., 2003

 

(16) Kayser, O., Müller, R. H. (Hrsg), Biotechnologia Farmaceutiyczna, polnische Übersetzung des Buches „Pharmazeutische Biotechnologie. Ein Kompendium für Forschung und Praxis“, Wydawnictwo Lekarskie PZWL Warschau, 415 S., 2003

 

(17) Kayser, O., Müller, R. H. (Hrsg), Pharmaceutical Biotechnology. Drug Discovery and Clinical Applications, Wiley-VCH, Weinheim, 311 S., 2004

 

(18) Müller, R. H., Hildebrand, G. E. (Hrsg), chinesische Übersetzung des Lehrbuches: Pharmazeutische Technologie: Moderne Arzneiformen, Lehrbuch für Studierende der Pharmazie - Nachschlagewerk für Apotheker in Offizin, Krankenhaus und Forschung, 2. erweiterte Aufl., People’s Military Medical Press, 341 S., 2004

 

(19) Keck, C.M., Müller, R. H., Moderne Pharmazeutische Technologie (Modern Pharmaceutics), Lehrbuch für Studierende der Pharmazie & Nachschlagewerk für Apotheker in Offizin und Forschung, www.pharmazie-lehrbuch.de, 2009

 

 

 

 

Book chapters:

 

(1)   Müller, R. H., Polydispersität, elektrophoretische Beweglichkeit hochdisperser Systeme, PhD thesis, University of Kiel, Germany, 1983

 

(2)   Davis, S. S., Douglas, S., Illum, L., Jones. P. D. E., Mak, E., Müller, R. H., "Targeting of Colloidal Carriers and the Role of Surface Properties", in: Targeting of Drugs with Synthetic Systems (Gregoriadis, G., Senior, J. und Poste, G., eds.) Plenum, 123, 1986

 

(3)   Müller, R. H., Davis, S. S., Illum, L., Mak, E., "Particle Charge and Surface Hydrophobicity of Colloidal Drug Carriers", in: Targeting of Drugs with Synthetic Systems (Gregoriadis, G., Senior, J. und Poste, G., eds.) Plenum, 239 ,1986

 

(4)   Müller, R. H., Heinemann, S., Surface Modelling of Microparticles as Parenteral Systems with High Tissue Affinity, in: Bioadhesion - Possibilities and Future Trends (Gurny, R. and Junginger, H. E., eds.), Wissenschaftliche Verlagsgesellschaft Stuttgart, 202-214, 1989

 

(5)   Müller, R. H., Davis, S. S., Mak, E., "Surface Characterization of Colloidal Drug Carriers for Drug Targeting by Aqueous Two Phase Partitioning", in: Separation using Aqueous Phase Systems: Applications in Cell Biology and Biotechnology (Fisher, D. und Sutherland, I. A.,eds.) Plenum New York, 149-155, 1989

 

(6)   Müller, R. H., Heinemann, S., Blunk, T., Rudt, S., "PCS and zeta potential characterization of model drug carriers - essential information for the interpretation of in vitro and in vivo data", in: Laser Light Scattering in Biochemistry (Sattelle, D. B. and Harding, S., eds.), Redwood Press Ltd., Melksham, Wiltshire, 425-440, 1992

 

(7)   Müller, R. H., Feste Lipidnanopartikel (SLN), in: Pharmazeutische Technologie: Moderne Arzneiformen (Müller, R. H., Hildebrand, G. E. Hrsg.), Wissenschaftliche Verlagsgesellschaft Stuttgart, 265-272, 1997

 

(8)   Müller, R. H., „Nanosuspensionen - eine neue Formulierung für schwerlösliche Arzneistoffe“, in: Pharmazeutische Technologie: Moderne Arzneiformen (Müller, R. H., Hildebrand, G. E., Hrsg.), Wissenschaftliche Verlagsgesellschaft Stuttgart, 273-278, 1997

 

(9)   Müller, R. H., „Surface Hydrophobicity - Determination by ROSE Bengal (RB) Adsorption Methods“, in: Particle and Surface Characterisation Methods (Müller, R. H., Mehnert, W., Hrsg), Wissenschaftliche Verlagsgesellschaft Stuttgart, 215-228, 1997

 

(10) Thode, K., Müller, R. H., „Theory and Set Up of Hydrophobic Interaction Cromatography (HIC)“, in: Particle and Surface Characterisation Methods (Müller, R. H., Mehnert, W., Hrsg), Wissenschaftliche Verlagsgesellschaft Stuttgart, 229-234, 1997

 

(11) Müller, R. H., „HIC for the Determination of Surface Hydrophobicity of Particulates“, in: Particle and Surface Characterisation Methods (Müller, R. H., Mehnert, W., Hrsg), Wissenschaftliche Verlagsgesellschaft Stuttgart, 235-249, 1997

 

(12) Thode, K., Kresse, M., Müller, R. H., „HIC of Iron Oxide Dispersions Stabilized by Different Macromolecules“, in: Particle and Surface Characterisation Methods (Müller, R. H., Mehnert, W., Hrsg), Wissenschaftliche Verlagsgesellschaft Stuttgart, 251-259, 1997

 

(13) Müller, R. H., Lück, M., Harnisch, S., Thode, K., „Intravenously Injected Particles; Surface Properties and Interaction with Blood Proteins - the Key Determining the Organ Distribution“, in: Scientific and Clinical Applications of Magnetic Carriers (Schütt, W., Teller, J., Häfeli, U., Zborowski, M., eds.), 135-148, 1997

 

(14) Müller, R. H., Solid Lipid Nanoparticles, nanosuspensions and liposomes for pharmaceutical and cosmetic applications, in: Future Strategies for Drug Delivery with Particulate Systems (Diederichs, J.E. and Müller, R.H., eds.), CRC Press Boca Raton, 71-72, 1998

 

(15) Müller, R. H., Particulate systems for the controlled delivery of active compounds in pharmaceutics and cosmetics, in: Future Strategies for Drug Delivery with Particulate Systems (Diederichs, J.E. and Müller, R.H., eds.), CRC Press Boca Raton, 73-90, 1998

 

(16) Runge, S. A., Müller, R. H., Solid lipid nanoparticles (SLN™) for oral administration - drug incorporation and degradation, in: Future Strategies for Drug Delivery with Particulate Systems (Diederichs, J.E. and Müller, R.H., eds.), CRC Press Boca Raton, 91-100, 1998

 

(17) Peters, K., Müller, R. H., Nanosuspensions - a novel formulation of poorly soluble drugs, in: Future Strategies for Drug Delivery with Particulate Systems (Diederichs, J.E. and Müller, R.H., eds.), CRC Press Boca Raton, 101-108, 1998

 

(18) Lück, M., Paulke, B.-P., Schröder, W., Müller, R. H.,Two-dimensional electrophoresis (2-DE) for the determination of plasma proteins adsorbed on model drug carriers, in: Future Strategies for Drug Delivery with Particulate Systems (Diederichs, J. E. and Müller, R. H., eds.), CRC Press Boca Raton, 109-117, 1998

 

(19) Herbort, J., Diederichs, J. E., Müller, R. H., Development of a liposomal formulation for hair care use, in: Future Strategies for Drug Delivery with Particulate Systems (Diederichs, J. E. and Müller, R. H., eds.), CRC Press Boca Raton, 118-126, 1998

 

(20) Müller, R H., Runge, S. A. „Solid Lipid Nanoparticles (SLN^Ò) for controlled drug delivery“, in: Submicron Emulsions in Drug Targeting and Delivery (Benita, S., ed.), 219-234, 1998

 

(21) Müller, R. H., Böhm, B. H. L., Nanosuspensions, in: Emulsions and Nanosuspensions for the Formulation of Poorly Soluble Drugs (Müller, R. H., Benita, S., Böhm, B. H. L., eds.), medpharm Scientific Publishers Stuttgart, 149-174, 1998

 

(22) Müller, R. H., Feste Lipidnanopartikel (SLN), in: Pharmazeutische Technologie: Moderne Arzneiformen (Müller, R. H., Hildebrand, G. E. Hrsg.), 2. Auflage, Wissenschaftliche Verlagsgesellschaft Stuttgart, 357-366, 1998

 

(23) Müller, R. H., Alkoholische Pflanzenextrakte, in: Pharmazeutische Technologie: Moderne Arzneiformen (Müller, R. H., Hildebrand, G. E. Hrsg.), 2. Auflage, Wissenschaftliche Verlagsgesellschaft Stuttgart, 119-120, 1998

 

(24) Müller, R. H., „Nanosuspensionen - eine neue Formulierung für schwerlösliche Arzneistoffe“, in: Pharmazeutische Technologie: Moderne Arzneiformen (Müller, R. H., Hildebrand, G. E., Hrsg.), 2. Auflage, Wissenschaftliche Verlagsgesellschaft Stuttgart, 393-400, 1998

 

(25) Müller, R. H., Nanorozproszenia jako nowe postacie leku dla trudno rozpuszczalnych substancji leczniczych, in: Kubis, A., Jachowicz, R., Müller, R. H., Hildebrand, G. E., Technologia nowoczesnych postaci leków, Wydawnictwo Lekarskie PZWL, Warschau, 300-306, 1998

 

(26) Gref, R., Quellec, P., Alonso, M. J., Tobio, M., Lück, M., Müller, R. H., Dellacherie, E., PEG-Coated Nanospheres: Surface Optimization and Therapeutic Applications, in: Targeting of Drugs: Strategies for Stealth Therapeutic Systems, (Gregoriadis, G., ed.), Kluwer Academic Pub, 275-286, 1998

 

(27) Müller, R. H., Alkoholové rastliniié extrakty, in: Zabka, M., Müller, R. H., Hildebrand, G. E., Moderné lieky vo farmaceutickej technológii, slovakische Übersetzung des Lehrbuchs „Pharmazeutische Technologie: Moderne Arzneiformen“, 119-120, 1999

 

(28) Müller, R. H., Tuhé lipidové nanocastice (SLN), in: Zabka, M., Müller, R. H., Hildebrand, G. E., Moderné lieky vo farmaceutickej technológii, slovakische Übersetzung des Lehrbuchs „Pharmazeutische Technologie: Moderne Arzneiformen“, 373-382, 1999

 

(29) Müller, R. H., Nanosuspenzie – nová formulácia pre t’azko rozpustné liecivá, in: Zabka, M., Müller, R. H., Hildebrand, G. E., Moderné lieky vo farmaceutickej technológii, slovakische Übersetzung des Lehrbuchs „Pharmazeutische Technologie: Moderne Arzneiformen“, 409-416, 1999

 

(30) Müller, R. H., Jacobs, C., Kayser, O., Nanosuspensions for the Formulation of Poorly Soluble Drugs, in: Pharmaceutical Emulsions and Suspensions (Nielloud, F. and Marti-Mestres, G., eds.), Marcel Dekker, 383-407, 2000

 

(31) Müller, R. H., Olbrich, C., Neue Adjuvantien in der Impfstofftechnologie, in: Pharmazeutische Biotechnologie (Kayser, O., Müller, R. H., eds.), Wissenschaftliche Verlagsgesellschaft, 283-302, 2000

 

(32) Müller, R. H., Böhm, B. H. L., Grau, M. J., Nanosuspensions - a formulation approach for poorly soluble and poorly bioavailable drugs, in: Handbook of Pharmaceutical Controlled Release Technology (Wise, D., ed.), 345-357, 2000

 

(33) Müller, R. H., Dingler, A., Schneppe, T., Gohla, S., Large scale production of solid lipid nanoparticles (SLN^TM) and nanosuspensions (DissoCubes^TM), in: Handbook of Pharmaceutical Controlled Release Technology (Wise, D., ed.), 359-376, 2000

 

(34) Müller, R. H., Lippacher, A., Gohla, S., Solid Lipid Nanoparticles (SLN^â) as Carrier System for the Controlled Release of Drugs, in: Handbook of Pharmaceutical Controlled Release Technology (Wise, D., ed.), 377-391, 2000

 

(35) Müller, R. H., Wissing, S. A., Solid lipid nanoparticles (SLN^®, Lipopearls^®) for controlled delivery of active compounds, STP Pharma Sciences, Minutes Book

 

(36) Müller, R. H., Karsubke, G., Lemke, A., Nanosuspension system for oral delivery of poorly soluble drugs, 11^th Conference book of DMV Symposion on solid dosage formulation, DMV Japan, 26-25, 2002

 

(37)  Müller, R. H., Radtke, M., Wissing, S., Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations, in: Human Skin, the Medium of Touch, Bulletin Technique Gattefossé 2002, 131-152, 2002

 

(38) Müller, R. H., Wissing, S. A., SLN and Lipopearls for topical delivery of active compounds and contolled release, in: Modified-Release Drug Delivery Systems (Rathbone, M. J., Hadgraft, J., Roberts, M. S., eds.), Marcel Dekker, 571-587, 2003

 

(39) Müller, R. H., Jacobs, C., Kayser, O., DissoCubes – a novel formulation for poorly soluble and poorly bioavailable drugs, in: Modified-Release Drug Delivery Systems (Rathbone, M. J., Hadgraft, J., Roberts, M. S., eds.), Marcel Dekker, 135-149, 2003

 

(40) Müller, R. H., Lipid-Nanopartikel (SLN, NLC) zur Verkapselung von kosmetischen Wirkstoffen, in: Kosmetikjahrbuch 2003, Global Ingredient & Formulation Guide, Verlag für chemische Industrie, Augsburg, 481-484, 2003

 

(41) Müller, R. H., Akkar, A., Drug nanocrystals of poorly soluble drugs, in: Encyclopedia of Nanoscience and Nanotechnology (H. S. Nalwa, ed.), American Scientific Publishers, 627-638, 2004

 

(42) Müller, R. H., Radtke, M., Wissing, S. A., Solid Lipid Nanoparticles and Nanostructured Lipid Carriers, in: Encyclopedia of Nanoscience and Nanotechnology (H. S. Nalwa, ed.), American Scientific Publishers, 43-56, 2004

 

(43) Wissing, S., Müller, R. H., Cosmetic applications of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), in: Textbook of Cosmetic Dermatology, 3rd Edition (Baran, R., Mailbach, H. I., eds.), Taylor & Francis, 71-76, 2004

 

(44) Kayser, O., Müller, R. H., A primer on Pharmaceutical Biotechnology and industrial applications, in: Pharmaceutical Biotechnology (O. Kayser, R. H. Müller, eds.), Wiley-VCH, 3-8, 2004

 

(45) Olbrich, C., Tabatt, K., Wissing, S. A., Schöler, N., Müller, R. H., Solid Lipid Nanoparticles: Interaction with cells, cytokine production and enzymatic degradation, in: Lipospheres in Drug Targets and Delivery: Approaches, Methods and Applications (C. Nastruzzi, ed.), Routledge, 101-125, 2004

 

(46) Müller, R. H., Mehnert, W., Souto, E. B., Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for dermal delivery, in: Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methods, 4^th Edition (R. L. Bronaugh, H. I. Maibach, eds.), Marcel Dekker, 719-738, 2005

 

(47) Müller, R. H., Möschwitzer, J., Bushrab, F. N., Manufacturing of nanoparticles by milling and homogenisation techniques, in: Nanoparticle Technology for Drug Delivery (Gupta, Kompella, eds.), Marcel Dekker, 21-51, 2006

 

(48) Müller, R. H., Junghanns, J.-U., Drug nanocrystals/nanosuspensions for the delivery of poorly soluble drugs, in: Nanoparticulates as Drug Carriers (V. P. Torchilin, ed.), Imperial College Press, 307-328, 2006

 

(49) Müller, R. H., Souto, E. B., Göppert, T., Gohla, S., Production of biofunctionalized solid lipid nanoparticles (SLN) for site-specific drug delivery, in: Nanotechnologies for the Life Science: Biological and Pharmaceutical Materials (C. Kumar, ed.), Wiley-VCH, 287-303, 2006

 

(50) Müller, R. H., Göppert, T. M., Protein adsorption patterns on parenteral lipid formulations – key factor determining the in vivo fate, in: Role of Lipid Excipients in Modifying Oral and Parenteral Drug Delivery: Basic Principles and Biological Examples (Kishor M. Wasan, ed.), Wiley-VCH, 124-159, 2006

 

(51) Souto, E. B., Müller, R. H., Lipid nanoparticles (SLN and NLC) for drug delivery, in: Nanoparticles for pharmaceutical applications (A. Domb, Y Tobata, R. Kumar, S. Farber, eds.), American Scientific Publishers, 103-122, 2007

 

(52) Möschwitzer, J., Müller, R. H., Drug nanocrystals – the universal formulation approach for poorly soluble drugs, in: Nanoparticulate Drug Delivery Systems: Recent Trends and Emerging Technologies (D. Thassu, M. Deleers, Y. Pathak, eds.), Informa Healthcare, 2007

 

(53) Souto, E. B., Müller, R. H., Lipid nanoparticles (solid lipid nanoparticles and nanostructured lipid carriers) for cosmetic, dermal and transdermal applications, in: Nanoparticulate Drug Delivery Systems: Recent Trends and Emerging Technologies (D. Thassu, M. Deleers, Y. Pathak, eds.), CRC Press, 213-233, 2007

 

(54) Müller, R. H., Keck, C. M., Improvement of delivery & solubility of poorly soluble drugs by nanonisation, in: Konferenzdokumentation LTS Academy, 12-17, 4.-5. Oktober 2007

 

(55) Keck, C. M., Hommoss, A., Müller, R. H., Lipid nanoparticles (SLN, NLC, LDC) for the enhancement of oral absorption, in: Modified Release Drug Delivery Technology Vol. 1 (2^nd edition) (R. B. Walker, J. Hadgraft, M. S. Roberts, M. E. Lane, eds.), Informa Healthcare, 269-286, 2008

 

(56) Souto, E. B., Petersen, R., Müller, R. H., Lipid nanoparticles with solid matrix for dermal delivery: solid lipid nanoparticles and nanostructured lipid carriers, in: Modified Release Drug Delivery Technology Vol. 1 (2^nd edition) (M. J. Rathbone, J. Hadgraft, M. S. Roberts, eds.), Informa Healthcare, 357-379, 2008

 

(57) Souto, E. B., Müller, R. H., Challenging cosmetics: Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers NLC), in: Science and Applications of Skin Delivery Systems (J. Wiechers, A. Kozlowski, eds.), Allured Publishing, 227-250, 2008

 

(58) Souto, E. B., Müller, R. H., Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) – lipid nanoparticles for medicals and pharmaceuticals, in: Encyclopedia of Nanoscience and Nanotechnology, 2^nd Edition (H. S. Nalwa, ed.), American Scientific Publishers, 2009

 

(59) Souto, E. B., Teeranchaideekul, V., Boonme, P., Müller, R. H., Junyaprasert, V. B., Lipid-based nanocarriers for cutaneous administration of pharmaceutics, in: Encyclopedia of Nanoscience and Nanotechnology, 2^nd Edition (H. S. Nalwa, ed.), American Scientific Publishers, 2009

 

(60) Keck, C.M., Müller, R. H, Photonenkorrelationsspektroskopie, in: Moderne Pharmazeutische Technologie (C.M. Keck, R.H. Müller, eds.), 56-61, 2009

 

(61) Pardeike, J., Müller, R. H., Bestimmung der Hautfeuchtigkeit, Hautelastizität und des transepidermalen Wasserverlustes (TEWL), in: Moderne Pharmazeutische Technologie (C.M. Keck, R.H. Müller, eds.), 84-87, 2009

 

(62) Pardeike, J., Müller, R. H., HET-CAM Test, in: Moderne Pharmazeutische Technologie (C.M. Keck, R.H. Müller, eds.), 91-93, 2009

 

(63) Pardeike, J., Müller, R. H., Tape Stripping Test, in: Moderne Pharmazeutische Technologie (C.M. Keck, R.H. Müller, eds.), 110-112, 2009

 

(64) Keck, C. M., Al Shaal, L., Müller, R. H., smartCrystals – review of the second generation of drug nanocrystals, in: Handbook of Materials for Nanomedicine (V. Torchillin, M. M. Amiji, eds.), Pan Stanford Series on Biomedical Nanotechnology, Pan Stanford Publishing, London, 555-580, 2010

 

(65) Souto, E. B., Müller, R. H., Lipid nanoparticles – effect on bioavailability and pharmacokinetic changes, in: Handbook of Experimental Pharmacology, Handbook of Experimental Pharmacology Vol 197: Drug Delivery, Springer Publishing House, 115-141, 2010

 

(66) Souto, E. B., Keck, C., Müller, R. H., Technology of lipid nanoparticles (SLN, NLC) as nanocarriers for skin applications: properties, production & cosmetic formulations, in: Cosmetics: Types, Allergies and Applications,  Laura M. Hayes (Ed.), Nova Scientific Publishers, Hauppauge, New York, USA, Chapter 3, 2010

 

(67) Souto, E. B., Teeranachaideekul, V., Boonme, P., Müller, R. H., Lipid-based nanocarriers for cutaneous administration of pharmaceutics, in: Encyclopedia of Nanoscience and Nanotechnology Vol. 15 (H. S. Nalwa, ed.), American Scientific Publishers, Valencia/USA, 479-491, 2011

 

(68) Souto, E. B., Müller, R. H., Solid lipid nanoparticles and nanostructured lipid carriers – lipid nanoparticles for medicals and pharmaceuticals, in: Encyclopedia of Nanoscience and Nanotechnology Vol. 23 (H. S. Nalwa, ed.), American Scientific Publishers, Valencia/USA, 313-328, 2011

 

(69) Möschwitzer, J., Müller, R. H., Nanocrystal formulations for improved delivery of poorly soluble drugs, in: Nanomedicines in Health and Disease, submitted

 

(70) Müller, R. H., Shegokar, R., Gohla, S., Keck, M., Nanocrystals: production, cellular drug delivery, current & future products, in: Intracellular Drug Delivery: fundamentals and applications (A. Prokop, ed.), Springer New York, submitted

 

Refereed papers:

 

(1)   Müller, B. W. und Müller, R. H., Particle Size Analysis of Latex Suspensions and Microemulsions by Photon Correlation Spectroscopy, J. Pharm. Sci. 73 (7), 915-918, 1984

 

(2)   Müller, B. W. und Müller, R. H., Particle Size Distributions and Particle Size Alterations in Microemulsions, J. Pharm. Sci. 73 (7), 919-922, 1984

 

(3)   Müller, B. W., Merz, J. und Müller, R. H., Simultane Bestimmung von elektrophoretischer Beweglichkeit und Teilchengröße bei überlagerter Konvektion an Suspensionen und Emulsionen, Colloid & Polymer Sci. 263, 342-347, 1985

 

(4)   Illum, L., Davis, S. S., Müller, R. H., Mak, E. und West, P., The organ distribution and circulation time of intravenously injected colloidal carriers sterically stabilized with a blockcopolymer - poloxamine 908, Life Sciences 40, 367-374, 1987

 

(5)   Illum, L., Jacobsen, L. O., Müller, R. H., Mak, E. und Davis, S. S., Surface Characteristics and the Interaction of Colloidal Particles with Mouse Peritoneal Macrophages, Biomaterials 8, 113-117, 1987

 

(6)   Koosha, F., Müller, R. H., Davis, S. S., Polyhydroxybutyrate as a Drug Carrier, Critical Reviews in Therapeutic Drug Carrier Systems 6, (2), 117-130, 1989

 

(7)   Koosha, F., Müller, R. H., Davis, S. S. und Davies, M. C., The Surface Chemical Structure of Poly (ß-hydroxybutyrate) Microparticles Produced by Solvent Evaporation Process, J. Contr. Rel. 9, 149-157, 1989

 

(8)   Davis, S. S., Illum, L., Müller, R. H., Landry, F., Wright, J., Harper, G., The Effect of Infused Fat Emulsions on Reticuloendothelial Function in the Rabbit, Clinical Nutrition 9, 260-265, 1990

 

(9)   Lucks, J. S., Müller, B. W., Müller, R. H., Inorganic Suspensions - Interaction with Salts and Ionic Surfactants, Int. J. Pharm. 58, 229-235, 1990

 

(10) Müller, R. H., Lherm, C., Herbort, J., Couvreur, P., In Vitro Model for the Degradation of Alkylcyanoacrylate Nanoparticles, Biomaterials 11, 590-595, 1990

 

(11) Lucks, J. S., Müller, B. W., Müller, R. H., Polymeric and emulsion carriers - Interaction with antiflocculants and ionic surfactants, Int. J. Pharm. 63, 183-188, 1990

 

(12) Wallis, K. H., Müller, R. H., Stabilität von Poloxamer und Poloxamine Coatingfilmen auf Polystyrol Nanopartikeln, Acta Pharm. Technol. 36 (3), 127-132, 1990

 

(13) Carstensen, H., Müller, B. W., Müller, R. H., Adsorption of ethoxylated surfactants on nanoparticles. I. Characterization by Hydrophobic Interaction Chromatography, Int. J. Pharm. 67, 29-37, 1991

 

(14) Müller, R. H., Lherm, C., Herbort, J., Couvreur, P., Propidium Iodide Loaded Polyalkylcyanoacrylate Particles - Labelling Conditions and Loading Capacity, Colloid & Polym. Sci. 269, 147-152, 1991

 

(15) Stampa, B., Lucks, J. S., Müller, B. W., Müller, R. H., Electrophoretic properties of emulsions for parenteral nutrition determined by laser light scattering and application of the amplitude weighted phase structure function (AWPS), J. Coll. Interf. Sci. 143 (1), 188-194, 1991

 

(16) Lukowski, G., Müller, R. H., Müller, B. W., Dittgen, M., Acrylic acid copolymer nanoparticles for drug delivery. I: Characterization of the surface properties relevant for in vivo organ distribution, Int. J. Pharm. 84, 23-31, 1992

 

(17) Müller, R. H., Heinemann, S., Fat emulsions for parenteral nutrition I: Evaluation of microscopic and laser light scattering methods for the determination of the physical stability, Clinical Nutrition 11, 223-236, 1992

 

(18) Tröster, S. D., Wallis, K. H., Müller, R. H., Kreuter, J., Correlation of the surface hydrophobicity of ¹⁴C-poly (methyl methacrylate) nanoparticles to their body distribution, J. Control. Rel. 20, 247-260, 1992

 

(19) Müller, R. H., Wallis, K. H., Tröster, S. D., Kreuter, J., In vitro characterization of poly (methyl methacrylate) nanoparticles and correlation to their in vivo fate, J. Control. Rel. 20, 237-246, 1992

 

(20) Müller, R. H., Lherm, C., Herbort, J., Blunk, T., Couvreur, P., Alkylcyanoacrylate Drug Carriers I: Physicochemical Characterization of Nanoparticles with Different Alkyl Chain Length, Int. J. Pharm. 84, 1-11, 1992

 

(21) Lherm, C., Müller, R. H., Puisieux F., Couvreur, P., Alkylcyanoacrylate Drug Carriers II: Cytotoxicity of Cyanoacrylate Nanoparticles with Different Alkyl Chain Length, Int. J. Pharm. 84, 13-22, 1992

 

(22) Carstensen, H., Müller, R. H., Müller, B. W., Particle size, surface hydrophobicity and interaction with serum of parenteral fat emulsions and model drug carriers as parameters related to RES uptake, Clinical Nutrition 11, 289-297, 1992

 

(23) Rudt, S., Müller, R. H., In vitro phagocytosis assay of nano- and microparticles by chemiluminescence. I. Effect of analytical parameters, particle size and particle concentration, J. Control. Rel. 22, 263-272, 1992

 

(24) Lukowski, G., Müller, R. H., Müller, B. W., Dittgen, M., Acrylic acid copolymer nanoparticles for drug delivery. II: Characterization of nanoparticles surface-modified by adsorption of ethoxylated surfactants, Colloid & Polym. Sci. 271, 100-105, 1993

 

(25) Müller, R. H., Wallis, K. H., Surface modification of i.v. injectable biodegradable nanoparticles with poloxamer polymers and poloxamine 908, Int. J. Pharm. 89, 25-31, 1993

 

(26) Wesemeyer, H., Müller, B. W., Müller, R. H., Adsorption of ethoxylated surfactants on nanoparticles. II. Determination of adsorption enthalpy by microcalorimetry, Int. J. Pharm. 89, 33-40, 1993

 

(27) Müller, R. H., Heinemann, S., Fat emulsions for parenteral nutrition II: Characterization and physical long-term stability of Lipofundin MCT/LCT, Clinical Nutrition 12, 298-309, 1993

 

(28) Maaßen, S., Fattal, E., Müller, R. H., Couvreur, P., Cell cultures for the assessment of toxicity and uptake of polymeric particulate drug carriers, S.T.P. Pharma Sciences 3 (1), 11-22, 1993

 

(29) Rudt, S., Müller, R. H., In vitro phagocytosis assay of nano- and microparticles by chemiluminescence. II. Effect of surface modification by coating of particles with poloxamer on the phagocytic uptake, J. Control. Rel. 25, 51-59, 1993

 

(30) Rudt, S., Müller, R. H., In vitro phagocytosis assay of nano- and microparticles by chemiluminescence. III. Uptake of differently sized surface-modified particles, and its correlation to particle properties and in vivo distribution, Eur. J. Pharm. Sci. 1, 31-39, 1993

 

(31) Rudt, S., Wesemeyer, H., Müller, R. H., In vitro phagocytosis assay of nano- and microparticles by chemiluminescence. IV. Effect of surface modification by coating of particles with poloxamine and Antarox CO on the phagocytic uptake, J. Control. Rel. 25, 123-132, 1993

 

(32) Rudt, S., Müller, R. H., In vitro uptake of polystyrene latex particles and parenteral fat emulsions by human granulocytes, Int. J. Pharm. 99, 1-6, 1993

 

(33) Blunk, T., Hochstrasser, D. F., Sanchez, J.-C., Müller, B. W., Müller, R. H., Colloidal Carriers for Intravenous Drug Targeting: Plasma Protein Adsorption Patterns on Surface-Modified Latex Particles Evaluated by Two-dimensional Polyacrylamide Gel Electrophoresis, Electrophoresis 14, 1382-1387, 1993

 

(34) Schwarz, C., Mehnert, W., Lucks, J. S., Müller, R. H., Solid lipid nanoparticles (SLN) for controlled drug delivery. I. Production, characterization and sterilization, J. Control. Rel. 30, 83-96, 1994

 

(35) Bock, T. K., Lucks, J. S., Kleinebudde P., Müller R. H., Müller B. W., High Pressure Homogenisation of Parenteral Fat Emulsions - Influence of Process Parameters on Emulsion Quality, Eur. J. Pharm. Biopharm. 40 (3), 157-160, 1994

 

(36) Müller, R. H., Heinemann, S., Fat emulsions for parenteral nutrition III: Lipofundin MCT/LCT regimens for total parenteral nutrition (TPN) with low electrolyte load, Int. J. Pharm. 101, 175-189, 1994

 

(37) Müller, R. H., Heinemann, S., Fat emulsions for parenteral nutrition IV: Lipofundin MCT/LCT regimens for total parenteral nutrition (TPN) with high electrolyte load, Int. J. Pharm. 107, 121-132, 1994

 

(38) Paulke, B.-R., Möglich, P.-M., Knippel, E., Budde, A., Nitzsche, R., Müller, R. H., Electrophoretic 3D-mobility profiles of latex particles with different surface groups, Langmuir 11, 70-74, 1995

 

(39) Gref, R., Domb, A., Quellec, P., Blunk, T., Müller, R. H., Verbavatz, J. M., Langer, R., The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres, Adv. Drug Deliv. Rev. 16, 215-233, 1995

 

(40) Müller, R. H., Mehnert, W., Lucks, J. S., Schwarz, C., zur Mühlen, A., Weyhers, H., Freitas, C., Rühl, D., Solid Lipid Nanoparticles (SLN) - An Alternative Colloidal Carrier System for Controlled Drug Delivery, Eur. J. Pharm. Biopharm. 41 (1), 62-69, 1995

 

(41) Blunk, T., Lück, M., Calvör, A., Hochstrasser, D. F., Sanchez, J.-C., Müller, B. W., Müller, R. H., Kinetics of Plasma Protein Adsorption on Model Particles for Controlled Drug Delivery and Drug Targeting, Eur. J. Pharm. Biopharm. 42 (4), 262-268, 1996

 

(42) Zingel, C., Sachse, A., Rößling, G. L., Müller, R. H., Lyophilization and Rehydration of Iopromide-Carrying Liposomes, Int. J. Pharm. 140, 13-24, 1996

 

(43) Hedemann, H., Lück, M., Blunk, T., Frokjaer, S., Müller, R. H., Fat emulsions based on structured lipids (1,3-specific triglycerides): An investigation of the in vitro interaction with plasma protein, Clin. Nutr. 15, 175-178, 1996

 

(44) Müller, R. H., Maaßen, S., Weyhers, H., Specht, F., Lucks, J. S., Cytotoxicity of magnetite loaded polylactide, polylactide/glycolide particles and solid lipid nanoparticles (SLN), Int. J. Pharm. 138, 85-94, 1996

 

(45) Ehlers, S., Bucke, W., Leitzke, S., Fortmann, L., Smith, D., Hänsch, H., Hahn, H., Bancroft, G., Müller, R. H., Liposomal amikacin for treatment of M. avium infections in clinically relevant experimental settings, Int. J. Med. Microbiol. Virol. Parasitol. Infect. Dis. 284, 218-231, 1996

 

(46) Müller, R. H., Maaßen, S., Weyhers, H., Mehnert, W., Phagocytic uptake and cytotoxicity of solid lipid nanoparticles (SLN) sterically stabilized with Poloxamine 908 and Poloxamer 407, J. Drug Targeting 4 (3), 161-170, 1996

 

(47) Müller, R. H., Rühl, D., Lück, M., Paulke, B.-R., Influence of fluorescent labelling of polystyrene particles on phagocytic uptake, surface hydrophobicity and plasma protein adsorption, Pharm. Res. 14 (1), 18-24, 1997

 

(48) Diederichs, J. E., Müller R. H., Microviscosity Measurements: Theory and Application for Parenteral Fat Emulsions, Pharm. Tech., Jan. 1997, 41-56, 1997

 

(49) Almeida, A. J., Runge, S., Müller, R. H., Peptide-loaded Solid Lipid Nanoparticles (SLN): Influence of production parameters, Int. J. Pharm. 149, 255-265, 1997

 

(50) Müller, R. H., Maaßen, S., Schwarz, C., Mehnert, W., Solid Lipid Nanoparticles (SLN) formulation for human use: interaction with human granulocytes, J. Contr. Rel. 47, 261-269, 1997

 

(51) Rühl. D., Schulze-Forster, K., Müller, R. H., Interaction of differentiated HL60 cells with Poloxamer and Poloxamine surface modified model drug carriers, Eur. J. Pharm. Biopharm. 5, 147-153, 1996

 

(52) Müller, R. H., Rühl, D., Runge, S., Biodegradation of SLN as a Function of Lipase Incubation time, Int. J. Pharm. 144, 115-121,1997

 

(53) Müller, R. H., Rühl, D., Runge, S., Schulze-Forster, K., Mehnert, W., Cytotoxicity of Solid Lipid Nanoparticles as a Function of the Lipid Matrix and the Surfactant, Pharm. Res. 14 (4), 458-462, 1997

 

(54) Thode, K., Lück, M., Kresse, M., Semmler, W., Müller, R. H., Determination of Plasma Protein Adsorption on Magnetic Iron Oxides: Sample Preparation, Pharm. Res. 14 (7), 905-910, 1997

 

(55) Müller, R. H., Weyhers, H., zur Mühlen, A., Dingler, A., Mehnert, W., Solid Lipid Nanoparticles (SLN) - ein neuartiger Wirkstoff-Carrier für Kosmetika und Pharmazeutika, I. Systemeigenschaften, Herstellung und Scaling up, Pharm. Ind. 59 (5), 423-427, 1997

 

(56) Mehnert, W., zur Mühlen, A., Dingler, A., Weyhers, H., Müller, R. H., Solid Lipid Nanoparticles (SLN) - ein neuartiger Wirkstoff-Carrier für Kosmetika und Pharmazeutika, II. Wirkstoff-Inkorporation, Freisetzung und Sterilisierbarkeit, Pharm. Ind. 59 (6), 511-514, 1997

 

(57) Müller, R. H., Dingler, A., Weyhers, H., zur Mühlen, A., Mehnert, W., Solid Lipid Nanoparticles (SLN) - ein neuartiger Wirkstoff-Carrier für Kosmetika und Pharmazeutika, III. Langzeitstabilität, Gefrier- und Sprühtrocknung, Anwendung in Kosmetika und Pharmazeutika, Pharm. Ind. 59 (7), 614-619, 1997

 

(58) Müller, R. H. and Runge, S. A., Kontrolowane dawkowanie leku za pomoca koloidalnych nošników (Kontrollierte Arzneistoffapplikation mit kolloidalen Carriern), Roczniki Naukowe, 1997

 

(59) Lück, M., Schröder, W., Harnisch, S., Thode, K., Blunk, T., Paulke, B.-R., Kresse, M., Müller, R. H., Identification of plasma proteins facilitated by enrichment on particulate surfaces: Analysis by two-dimensional electrophoresis and N-terminal microsequencing, Electrophoresis 18, 2961-2967, 1997

 

(60) Lück, M., Paulke, B.-R., Schröder, W., Blunk, T., Müller, R. H., Analysis of plasma protein adsorption on polymeric nanoparticles with different surface characteristics, J. Biomed. Mat. Res., 478-485, 1997

 

(61) Bucke, W. E., Leitzke, S., Diederichs, J. E., Borner, K., Hahn, H., Ehlers, Müller, R. H., Surface-modified amikacin-liposomes: Organ distribution and interaction with plasma proteins, J. Drug Targ. 5 (2), 99-108, 1997

 

(62) Thode, K., Lück, M., Schröder, W., Kresse, M., Semmler, W., Müller, R. H., Influence of the sample preparation on plasma protein adsorption onto macromolecule stabilized iron oxide particles and N-terminal microsequencing of unknown proteins, J. Drug Targ. 5 (1), 35-43, 1997

 

(63) Müller, R .H., Peters, K., Nanosuspensions for the formulation of poorly soluble drugs. I. Preparation by a size-reduction technique, Int. J. Pharm. 160, 229-237, 1998

 

(64) Schuhmann, R., Müller, R. H., Optimierung der Probenaufbereitung für Coulter-Counter-Messungen, Pharm. Ind. 60 (2), 157-163, 1998

 

(65) Harnisch, S., Müller, R .H., Plasma protein adsorption patterns on emulsions for the parenteral administration: Establishment of a protocol for two-dimensional polyacrylamide electrophoresis. Electrophoresis, 19, 349-354,1998

 

(66) Lück, M., Pistel, K. F., Li, Y.-X., Blunk, T., Müller, R. H., Kissel, T., Plasma protein adsorption on biodegradable microspheres consisting of poly (DL-lactide-co-glycolide), poly(L-lactide) or ABA triblock copolymers containing poly(oxyethylene): Influence of production method and polymer composition, J. Control. Rel. 55, 107-120, 1998

 

(67) Leitzke, S., Bucke, W., Borner, K., Müller, R. H., Hahn, H., Ehlers, S., Rationale and efficacy of prolonged-interval treatment using liposome-encapsulated Amikacin in experimental M. avium infection, Antimicrob. Agents Chemother., 459-461, 1998

 

(68) Freitas, C., Müller, R. H., Spray Drying of Solid Lipid Nanoparticles (SLN™), Eur. J. Pharm. Biopharm. 46, 145-151, 1998

 

(69) Freitas, C., Müller, R. H., Effect of light and temperature on zeta potential and physical stability in Solid Lipid Nanoparticle (SLN™) Dispersions. Int. J. Pharm. 168, 221-229, 1998

 

(70) Thode, K., Lück, M., Schröder, W., Blunk, T., Müller, R. H., Kresse, M., The influence of the sample preparation on plasma protein adsorption patterns on polysaccharide-stabilized iron oxide particles and N-terminal microsequencing of unknown proteins, J. Drug. Targ. 5 (6), 459-469, 1998

 

(71) Freitas, C., Müller, R. H., Correlation between long-term stability of solid lipid nanoparticles (SLN™) and crystallinity of the lipid phase, Eur. J. Pharm. Biopharm. 47, 125-132, 1999

 

(72) Freitas, C., Müller, R. H., Stability Determination of Solid Lipid Nanoparticles (SLN™) in Aqueous Dispersion after Addition of Electrolyte, Journal of Microencapsulation 16 (1), 59-71, 1999

 

(73) Müller, R. H., Dobrucki, R., Radomska, A., Solid lipid nanoparticles as a new formulation with retinol, Acta Poloniae Pharmaceutica 56 (2), 117-120, 1999

 

(74) Müller, R. H., Böhm, B. H. L., Grau, M. J., Nanosuspensions - Formulierungen für schwerlösliche Arzneistoffe mit geringer Bioverfügbarkeit: I. Herstellung und Eigenschaften, Pharm. Ind. 61 (1), 74-78, 1999

(75) Müller, R. H., Böhm, B. H. L., Grau, M. J., Nanosuspensionen - Formulierungen für schwerlösliche Arzneistoffe mit geringer Bioverfügbarkeit: II. Stabilität, biopharmazeutische Aspekte, mögliche Arzneiformen und Zulassungsfragen, Pharm. Ind. 61 (2), 175-178, 1999

 

(76) Pinto, J. F., Müller, R. H., Pellets as carriers of solid lipid nanoparticles (SLN™) for oral administration of drugs, Die Pharmazie 54, 506-509, 1999

 

(77) Müller, R. H., Olbrich, C., Solid Lipid Nanoparticles (SLN): Phagocytic uptake, in vitro cytotoxity and in vivo biodegradation, 1^st Communication, Pharm. Ind. 61, 462-467, 1999

 

(78) Müller, R. H., Olbrich, C., Solid Lipid Nanoparticles (SLN): Phagocytic uptake, in vitro cytotoxity and in vivo biodegradation, 2^nd Communication, Pharm. Ind. 61, 564-569, 1999

 

(79) Olbrich, C., Müller, R. H., Enzymatic degradation of SLN - Effect of surfactant and surfactant mixtures, Int. J. Pharm. 180, 31-39, 1999

 

(80) Peters, K., Müller, R. H., Craig, D. Q. M., An Investigation into the Distribution of Lecithins [between Vesicles and Drug Particles] in Nanosuspension Systems using Low Frequency Dielectric Spectroscopy, Int. J. Pharm. 184, 53-61, 1999

 

(81) Dingler, A., Blum, R. P., Niehus, H., Gohla, S., Müller, R. H., Solid lipid nanoparticles (SLN^TM/Lipopearls^TM) - A pharmaceutical and cosmetic carrier for the application of vitamin E in dermal products, Journal of Microencapsulation 16 (6), 751-767, 1999

 

(82) Lück, M., Schröder, W., Paulke, B.-R., Blunk, T., Müller, R. H., Complement Activation by Model Drug Carries for Intravenous Application: Determination by Two-Dimensional Electrophoresis, Biomaterials 20, 2063-2068, 1999

 

(83) Peracchia, M. T., Harnisch, S., Pinto-Alphandary, H., Gulik, A., Dedieu, J. C., Desmaele, D., d‘Angelo, J., Müller, R. H., Couvreur, P., Visualization of in vitro protein-rejecting properties of pegylated stealth^â polycyanoacrylate nanoparticles, Biomaterials 20, 1269-1275, 1999

 

(84) Borner, K., Hartwig, H., Leitzke, S., Hahn, H., Müller, R. H., Ehlers, S., HPLC determination of clofazimine in tissues and serum of mice after intravenous administration of nanocrystalline or liposomal formulations, Antimicrob. Agents Chemother. 11, 75-79, 1999

 

(85) Anger, S., Caldwell, K., Niehus, H., Müller, R. H., High Resolution Size Determination of 20 nm Colloidal Gold Particles by SedFFF, Pharm. Res.16 (11), 1743-1747, 1999

 

(86) Böhm, B., Müller, R. H., Lab-scale production unit design for nanosuspensions of sparingly soluble cytotoxic drugs, Pharm. Science & Technology Today 2 (8), 336-339, 1999

 

(87) Müller, R. H., Olbrich, C., Solid Lipid Nanoparticles: Phagocytic uptake, in vitro cytotoxicity and in vitro biodegradation, Drugs 42, 65-88, 1999

 

(88) Radomska, R., Dobrucki, R., Müller, R. H., Chemical stability of the lipid matrices of solid lipid nanoparticles (SLN) – development of the analytical method and determination of long-term stability, Die Pharmazie, 54, 903-909, 1999

 

(89) Harnisch, S., Müller, R.H., Adsorption kinetics of plasma proteins on oil-in-water emulsions for parenteral nutrition, Eur. J. Pharm. Biopharm. 49, 41-46, 2000

 

(90) Müller, R. H., Harnisch, S., Physico-chemical characterization of propofol-loaded emulsions and interaction with plasma proteins, European Journal of Hospital Pharmacy 6/1, 24-31, 2000

 

(91) Peters, K., Leitzke, S., Diederichs, J. E., Borner, K., Hahn, H., Müller, R. H., Ehlers, S., Preparation of a clofazimine nanosuspension for intravenous use and evaluation of its therapeutic efficacy in murine Mycobacterium avium infection, Journal of Antimicrobial Chemotherapy 45 (1), 77-83, 2000

 

(92) Anger, S., Caldwell, D., Müller, R. H., Charakterisierung von Molekülen, Kolloiden und Partikeln mit der Field Flow Fractionation, Pharm. Ind. 62, 2, 150-156, 2000

 

(93) Gref, R., Quellec, P., Marchand M., Dellacherie, E., Lück, M., Harnisch, S., Blunk, T., Müller, R. H., „Stealth“ corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption, Colloids and Surfaces B: Biointerfaces 18 (3-4), 301-313, 2000

 

(94) Geßner, A., Paulke, B.-R., Müller, R. H., Analysis of plasma protein adsorption onto polystyrene particles by two-dimensional electrophoresis: Comparison of sample application and isoelectric focusing techniques, Electrophoresis 21, 2438-2442, 2000

 

(95) Rudolph, C., Lausier, J., Naundorf, S., Müller, R. H., Rosenecker, J., In vivo gene delivery to the lung using polyethylenimine and fractured polyamidoamine dendrimers, The Journal of Gene Medicine 2, 269-278, 2000

 

(96) Jacobs, C., Kayser, O., Müller, R. H., Nanosuspensions as a new approach for the formulation for the poorly soluble drug tarazepide, Int. J. Pharm.196, 161-164, 2000

 

(97) Liedtke, S., Wissing, S., Müller, R. H., Mäder, K., Influence of high pressure homogenisation equipment on nanodispersions characteristics, Int. J. Pharm.196, 183-185, 2000

 

(98) Schöler, N., Zimmermann, E., Katzfey, U., Hahn, H., Müller, R. H., Liesenfeld, O., Preserved solid lipid nanoparticles (SLN) at low concentrations do cause neither direct nor indirect cytotoxic effects in peritoneal macrophages, Int. J. Pharm.196, 235-239, 2000

 

(99) Krause, K. P., Kayser, O., Mäder, K., Gust, R., Müller, R. H., Heavy metal contamination of nanosuspensions produced by high-pressure homogenisation, Int. J. Pharm.196, 169-172, 2000

 

(100)Grau, M. J., Kayser, O., Müller, R. H., Nanosuspensions of poorly soluble drugs – reproducibility of small scale production, Int. J. Pharm.196, 155-157, 2000

 

(101)Seehof, K., Kresse, M., Mäder, K., Müller, R. H., Interactions of nanoparticles with body proteins – impovement of 2D-PAGE-analysis by internal standard, Int. J. Pharm.196, 231-234, 2000

 

(102)Geßner, A., Waicz, R., Lieske, A., Paulke, B.-R., Mäder, K., Müller, R. H., Nanoparticles with decreasing surface hydrophobicities: influence on plasma protein adsorption, Int. J. Pharm.196, 245-249, 2000

 

(103)Lippacher, A., Müller, R. H., Mäder, K., Investigation on the viscoelastic properties of lipid based colloidal drug carriers, Int. J. Pharm. 196, 227-230, 2000

 

(104)Zimmermann, E., Müller, R. H., Mäder, K., Influence of different parameters on reconstitution of lyophilized SLN, Int. J. Pharm. 196, 211-213, 2000

 

(105)Müller, R. H., Mäder, K., Gohla, S., Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art, Eur. J. Pharm. Biopharm. 50, 161-177, 2000

 

(106)Buszello, K., Harnisch, S., Müller, R. H., Müller, B. W., The influence of alkali fatty acids on the properties and the stability of parenteral O/W emulsions modified with Solutol HS 15^â, Eur. J. Pharm. Biopharm. 49, 143-149, 2000

 

(107)Krause, W., Schlichter-Hackmann, N., Maier, F. K., Müller, R. H., Dendrimers in Diagnostics, in: Topics in Current Chemistry. Vol. 210, 261-308, 2000

 

(108)Schöler, N., Zimmermann, E., Katzfey, U., Hahn, H., Müller, R. H., Liesenfeld, O., Effect of solid lipid nanoparticles (SLN) on cytokine production and the viability of murine peritoneal macrophages, Journal of Microencapsulation, 17 (5), 639-650, 2000

 

(109)Thode, K., Müller, R. H., Kresse, M., Two-time window and multi-angle photon correlation spectroscopy size & zeta potential analysis – highly sensitive rapid assay for dispersion stability, J. Pharm. Sci. 89(10), 1317-1324, 2000

 

(110)Krause, K., Müller, R. H., Production and characterisation of highly concentrated nanosuspensions by high pressure homogenisation, Int. J. Pharm. 214, 21-24, 2001

 

(111)Lippacher, A., Müller, R. H., Mäder, K., Preparation of semisolid drug carriers for topical application based on solid lipid nanoparticles, Int. J. Pharm. 214, 9-12, 2001

 

(112)Jacobs, C., Kayser, O., Müller, R. H., Production and characterisation of mucoadhesive nanosuspensions for the formulation of bupravaquone, Int. J. Pharm. 214, 3-7, 2001

 

(113)Geßner, A., Olbrich, C., Schröder, W., Kayser, O., Müller, R. H., The role of plasma proteins in brain targeting: species dependent protein adsorption patterns on brain-specific lipid drug conjugate (LDC) nanoparticles, Int. J. Pharm. 214, 87-91, 2001

 

(114)Demirel, M., Yazan, Y., Müller, R. H., Kilic, F., Bozan, B., Formulation and in vitro-in vivo evaluation of Piribedil solid lipid particles, Journal of Microencapsulation 18 (3), 359-371, 2001

 

(115)Schöler, N., Olbrich, C., Tabatt, K., Müller, R. H., Hahn, H., Liesenfeld, O., Surfactant, but not the size of solid lipid nanoparticles (SLN) influences viability and cytokine production of macrophages, Int. J. Pharm. 221, 57-67, 2001

 

(116)Müller, R. H., Jacobs, C., Kayser, O., Nanosuspensions as particulate drug formulations in therapy – Rationale for Development and what we can expect for the future, in: Advanced Drug Delivery Reviews (ADDR) 47, 3-19, 2001

 

(117)Schöler, N., Krause, K., Kayser, O., Müller, R. H., Hartwig, H., Hahn, H., Liesenfeld, O., Atovaquone nanosuspensions show excellent therapeutic effect in a new murine model of reactivated toxoplasmosis, Antimicrob. Agents Chemother., 1771-1779, 2001

 

(118)Wissing, S. A., Müller, R. H., A novel sunscreen system based on tocopherol acetate incorporated into solid lipid nanoparticles (SLN), Int. J. Cosmet. Sci. 23, 233-243, 2001

 

(119)Müller, R. H., Wissing, S. A., Radomska, A., Clinical batch production of peptide-loaded nanoparticles, NewDrugs 1, 72-74, 2001

 

(120)Krause, K. Müller, R. H., Production of aqueous shellac dispersions by high pressure homogenisation, Int. J. Pharm. 223, 89-92, 2001

 

(121)Radtke, M., Müller, R. H., NLC^® – Nanostructured lipid carriers: the new generation of lipid drug carriers, NewDrugs 2, 48-52, 2001

 

(122)Lind, K., Kresse, M., Müller, R. H., Evaluation of desorption of proteins adsorbed to hydrophilic surfaces by two-dimensional electrophoresis, Proteomics 1, 1059-1066, 2001

 

(123)Zimmermann, E., Müller, R. H., Electrolyte- and pH-stability of aqueous solid lipid nanoparticle (SLN^TM) dispersions in artificial gastrointestinal (GI) media, Eur. J. Pharm. Biopharm. 52, 203-210, 2001

 

(124)Wissing, S. A., Mäder, K., Müller, R. H., Solid lipid nanoparticles (SLN^TM) – a novel carrier for UV blockers, Die Pharmazie 10, 783-786, 2001

 

(125)Wissing, S. A., Lippacher, A., Müller, R. H., Investigations on the occlusive properties of solid lipid nanoparticles (SLN^TM), Journal of Cosmetic Science 52, 313-324, 2001

 

(126)Olbrich, C., Bakowsky, U., Lehr, C.-M., Müller, R. H., Kneuer, C., Cationic solid-lipid nanoparticles can efficiently bind and transfect plasmid DNA, Journal of Controlled Release 77, 345-355, 2001

 

(127)Seehof, K., Kresse, M., Müller, R. H., Comparison of protein adsorption patterns onto differently charged hydrophilic superparamagnetic iron oxide (SPIO) particles obtained in vitro and ex vivo, Electrophoresis 22 (16), 3514-3521, 2001

 

(128)Harnisch, S., Schuhmann, R., Harnisch, Jacob F., Müller, R. H., Differences in the coalescence kinetics of fat emulsions in dependence on the amount of fat and age, Die Pharmazie 57, 54-58, 2002

 

(129)Schöler, N., Hahn, H., Müller, R. H., Liesenfeld, O., Effect of lipid matrix and size of solid lipid nanoparticles (SLN) on the viability and cytokine production of macrophages, Int. J. Pharm. 231, 167-176, 2002

 

(130)Lind, Kathrin, Kresse, M., Debus, N. P., Müller, R. H., A novel formulation for superparamagnetic iron oxide (SPIO) particles enhancing MR lymphography: comparison of physicochemical properties and the in vivo behaviour, J. Drug. Targeting, 10 (3), 221-230, 2002

 

(131)Olbrich, C., Kayser, O., Müller, R. H., Lipase degradation of Dynasan 114 and Dynasan 116 Solid Lipid Nanoparticles (SLN) – effect of surfactants, storage time and crystallinity, Int. J. Pharm. 237, 119-128, 2002

 

(132)Funke, A. P., Schiller, R., Motzkus, H. W., Günther, C., Müller, R. H., Lipp, R., Transdermal delivery of highly lipophilic drugs: In-vitro fluxus of antiestrogens, permeation enhancers and solvents from liquid formulations, Pharm. Res. 19, No. 5, 661-668, 2002

 

(133)Müller, R. H., Schmidt, S., PathFinder technology for the delivery of drugs to the brain, NewDrugs 2, 38-42, 2002

 

(134)Geßner, A., Lieske, A., Paulke, B. R., Müller, R. H., Influence of surface charge density on protein adsorption on polymeric nanoparticles: analysis by two-dimensional electrophoresis, Eur. J: of Pharm. and Biopharm. 54 (2), 165-170, 2002

 

(135)Lippacher, A., Müller, R. H., Mäder, K., Semisolid SLN^TM dispersions for topical application: influence of formulation and production parameters on microstructure, Eur. J. Pharm. Biopharm. 53 (2), 155-160, 2002

 

(136)Funke, A., Günther, C., Müller, R. H., Lipp, R., In-vitro release and transdermal fluxes of a highly lipophilic drug and of enhancers from matrix TDS, J. Control. Rel. 82, 63-70, 2002

 

(137)Wissing, S., Müller, R. H., Solid lipid nanoparticles as carrier for sunscreens: in vitro release and in vivo skin penetration, J. Control. Rel. 81, 225-233, 2002

 

(138)Rudolph, C., Müller, R. H., Rosenecker, J., Jet nebulisation of PEI/DANN polyplexes: physical stability and in vitro gene delivery efficiency, Journal of Gene Medicine 4 (1), 66-74, 2002

 

(139)Jacobs, C., Müller, R. H., Production and characterizatoin of a budesonide nanosuspension for pulmonary administration, Pharm. Res. 19 (2), 189-194, 2002

 

(140)Müller, R. H., Jacobs, C., Buparvaquone mucoadhesive nanosuspensions: Preparation, optimisation and long-term stability, Int. J. Pharm. 237, 151-161 (2002)

 

(141)Olbrich, C., Geßner, A., Kayser, O., Müller, R. H., Lipid-drug conjugate (LDC) nanoparticles as novel carrier system for the hydrophilic antitrypanosomal drug Diminazenediaceturate, Journal of Drug Targeting 10 (5), 387-396, 2002

 

(142)Müller, R. H., Radtke, M., Wissing, S. A., Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations, Advanced Drug Delivery Reviews (ADDR) 54 Suppl. 1, S131-S155, 2002

 

(143)Rudolph, C., Schillinger, U., Plank, C., Geßner, A., Nicklaus, P., Müller, R. H., Rosenecker, J., Nonviral gene delivery to the lung with copolymer protected and transferring-modified polyethylenimine, Biochimica et Biophysica Acta 1573, 75-83, 2002

 

(144)Müller, R. H., Radtke, M., Wissing, S. A., Nanostructured lipid matrices for improved microencapsulation of drugs, Int. J. Pharm. 242, 121-128, 2002

 

(145)Olbrich, C., Kayser, O., Müller, R. H., Enzymatic degradation of Dynasan 114 SLN – effect of surfactants and particle size, Journal of Nanoparticle Research 4, 121-129, 2002

 

(146)Olbrich, C., Müller, R. H., Tabatt, K., Kayser, O., Schulze, C., Schade, R., Stable biocompatible adjuvants – a new type of adjuvant based on solid lipid nanoparticles: A Study on cytotoxicity, compatibility and efficacy in chicken, Atla 30, 443.458, 2002

 

(147)Wissing, S. A., Müller, R. H., The influence of the crystallinity of lipid nanoparticles on their occlusive properties, Int. J. Pharm. 242, 377-379, 2002

 

(148)Wissing, S. A., Müller, R. H., The development of an improved carrier system for sunscreen formulations based on crystalline lipid nanoparticles, Int. J. Pharm. 242, 373-375, 2002

 

(149)Rosenecker, J., Naundorf., S., Gersting, S. W., Hauck, R. W., Geßner, A. Nicklaus, P., Müller, R. H., Rudolph, C., Interaction of bronchoalveolar lavage fluid (BALF) with polyplexes and lipoplexes: analysing the role of proteins and glycoproteins, Journal of Gene Medicine 5(1), 49-60, 2003

 

(150)Wissing, S. A., Müller, R. H., Cosmetic applications for solid lipid nanoparticles (SLN), Int. J. Pharm. 254, 65-68, 2003

 

(151)Schmidt, S., Müller, R. H., Plasma protein adsorption patterns on surfaces of Amphotericin B-containing fat emulsions, Int. J. Pharm. 254, 3-5, 2003

 

(152)Rudolph, C., Plank, C., Lausier, J., Schillinger, U., Müller, R. H., Rosenecker, J., Oligomers of the arginine-rich motif of the HIV-1 TAT protein are capable of transferring plasmid DNA into cells, The Journal of Biological Chemistry 278 (13), 11411-11418, 2003

 

(153)Rank, F., Wozniewski, T., Müller, R. H., IMS – the future for chemical-pharmaceutical industry?, NewDrugs 3, 22-24, 2003

 

(154)Akkar, A., Müller, R. H., Formulation of intravenous Carbamazepin emulsions by SolEmuls technology, Eur. J. Pharm. Biopharm. 55, 305-312, 2003

 

(155)Akkar, A., Müller, R. H., Intravenous itraconazole emulsions produced by SolEmuls Technology, Eur. J. Pharm. Biopharm. 56, 29-36, 2003

 

(156)Wissing, S., Müller, R. H., The influence of solid lipid nanoparticles on skin hydration and viscoelasticity – in vivo study, Eur. J. Pharm. Biopharm. 56, 67-72, 2003

 

(157)Göppert, T. M., Müller, R. H., Plasma protein interactions of Tween 80- and poloxamer 188-stabilized SLN. Journal of Drug Targeting 11 (4), 225-231, 2003

 

(158)Funke, A., Günther, C., Müller, R. H., Lipp, R., Development of matrix patches for transdermal delivery of a highly lipophilic antiestrogen, Drug Dev. Ind. Pharm. 29 (7), 785-793, 2003

 

(159)Bushrab, F. N., Müller, R. H., Nanocrystals of poorly soluble drugs for oral administration, NewDrugs 5, 20-22, 2003

 

(160)Wissing, S. A., Saupe, A., Müller, R. H., Nanostructured lipid carriers (NLC) for topical use – an overview, Eurocosmetics 5, 14-17, 2003

 

(161)Geßner, A., Lieske, A., Paulke, B.-R., Müller, R. H., Functional groups on polystyrene model nanoparticles: Influence on protein adsorption, Journal of Biomedical Materials Research 65A, 319-326, 2003

 

(162)Müller, R. H., Schmidt, S., Buttle, S., Akkar, A., Schmitt, J., Brömer, S., SolEmuls^â – Novel technology for the formulation of i.v. emulsions with poorly soluble drugs, Int. J. Pharm. 269, 293-302, 2004

 

(163)Tabatt, K., Sameti, A., Olbrich, C., Müller, R. H., Lehr, C.-M., Effect of cationic lipid and matrix lipid composition on solid lipid nanoparticle-mediated gene transfer, Eur. J. Pharm. Biopharm. 57 (2), 155-162, 2004

 

(164)Olbrich, C., Geßner, A., Schröder, Kayser, O., Müller, R. H., Lipid-drug conjugate (LDC) nanoparticles of the hydrophilic drug diminazene - cytotoxicity testing and mouse serum adsorption, J. Controlled Release, 96 (3), 425-435, 2004

 

(165)Olbrich, C., Schöler, N., Tabatt, K., Kayser, O., Müller, R. H., Cytotoxicity studies of Dynasan 114 Solid Lipid Nanoparticles (SLN) on RAW 264.7 macrophages – impact of phagocytosis on viability and cytokine production, J. Pharm. Pharmacol. 56 (7), 883-891, 2004

 

(166)Rudolph, C., Schillinger, U., Ortiz, A., Tabatt, K., Plank, C., Müller, R. H., Rosenecker, J., Application of novel Solid Lipid Nanoparticle (SLN)-gene vector formulations based on a dimeric HIV-1 TAT-peptide in vitro and in vivo, Pharm. Res. 21 (9), 1662-1669, 2004

 

(167)Wissing, S., Müller, R. H., Manthei, L., Mayer, C., Structural characterization of Q10-loaded SLN by NMR spectroscopy, Pharm. Res. 21 (3), 400-405, 2004

 

(168)Rank, F., Scheuermann, H.-J., Wozniewski, T., Müller, R. H., Qualität, Umweltschutz und Sicherheit 2003 – Ein Einblick in die Organisation von Managementsystemen im Bereich der Produktion chemisch-pharmazeutischer Unternehmen in Deutschland, Pharm. Ind. 66 (7), 848-852, 2004

 

(169)Wissing, S. A., Kayser, O., Müller, R. H., Solid lipid nanoparticles for parenteral drug delivery, Advanced Drug Delivery Reviews (ADDR) 56, 1257-1272, 2004

 

(170)Göppert, T. M., Müller, R. H., Alternative sample preparation prior to two-dimensional electrophoresis protein analysis on solid lipid nanoparticles: development of optimized sample preparations method, Electrophoresis 25 (1), 134-140, 2004

 

(171)Akkar, A. Namsolleck, P., Blaut, M., Müller, R. H., Solubilising poorly soluble antimycotic agents by emulsification via a solvent-free process, AAPS PharmSciTech, 5 (2), Article 24, 2004

 

(172)Souto, E. B., Wissing, S. A., Barbosa, C. M., Müller, R. H., Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery, Int. J. Pharm. 278, 71-77, 2004

 

(173)Üner, M., Wissing, S. A., Yener, G., Müller, R. H., Influence of surfactants on the physical stability of solid lipid nanoparticle (SLN) formulations, Pharmazie 59, short communications, 331-332, 2004

 

(174)Tabatt, K., Kneuer, C., Sameti, M., Olbrich, C., Müller, R. H., Lehr, C.-M., Bakowsky, U., Transfection with solid lipid nanoparticles and liposomes: comparison of physical and biological performance, J. Control. Rel., 97, 321-332, 2004

 

(175)Souto, E. B., Wissing, S. A., Barbosa, C. M., Müller, R. H., Evaluation of the physical stability of SLN and NLC before and after incorporation into hydrogel formulations, Eur. J. Pharm. Biopharm. 58, 83-90, 2004

 

(176)Müller, R. H., Keck, C. M., Drug delivery to the brain – realisation by novel drug carriers, Journal of Nanoscience and Nanotechnology 4 (5), 471-483, 2004

 

(177)Souto, E. B., Wissing, S. A., Barbosa, C. M., Müller, R. H., Comparative study between the viscoelastic behaviour of different lipid nanoparticle formulations, International Journal of Cosmetic Science 55, 463-471, 2004

 

(178)Müller, R. H., Keck, C. M., Challenges and solutions for the delivery of biotech drugs – a review of drug nanocrystal technology and lipid nanoparticles, Journal of Biotechnology 113, 151-170, 2004

 

(179)Möschwitzer, J., Achleitner, G., Pomper, H., Müller, R. H., Development of an intravenously injectable chemically stable aqueous omeprazole formulation using nanosuspension technology, Eur. J. Pharm. Biopharm. 58, 615-619, 2004

 

(180)Rank, F., Wozniewski, T., Scheuermann, H.-J., Müller, R. H., Compliance aus Sicht der Industrie, Pharmazeutische Zeitung 40, 50-52, 2004

 

(181)Hernandez-Trejo, N., Hampe, A., Müller, R. H., A thin layer chromatography method to identify oxaliplatin in aqueous solution, Pharm.Ind. 66 (12), 1545-1550, 2004

 

(182)Akkar, A., Müller, R. H., Solubilisation by emulsification – novel formulation principle of poorly soluble drugs for intravenous administration, Pharm.Ind. 66 (12), 1537-1544, 2004

 

(183)Lippacher, A., Müller, R. H., Mäder, K., Liquid and semisolid SLN^TM dispersions for topical application: rheological characterization, Eur. J. Pharm. Biopharm. 58, 561-567, 2004

 

(184)Dunay, I. R., Heimesaat, M. M., Bushrab, F. N., Müller, R. H., Stocker, H., Arasteh, K., Kurowski, M., Fitzner, R., Borner, K., Liesenfeld, O., Atovaquone maintenance therapy prevents reactivation of toxoplasmic encephalitis in a murine model of reactivated toxoplasmosis, Antimicrob. Agents Chemother. 48 (12), 4848-4854, 2004

 

(185)Labarre, D., Vauthier, C., Chauvierre, C., Petri, B., Müller, R. H., Chehimi, M. M., Interactions of blood proteins with poly (isobutyleyanoacrylate) nanoparticles decorated with a polysaccharidic brush, Journal of Biomaterials 26, 5075-5084, 2005

 

(186)Schalper, K., Harnisch, S., Müller, R. H., Hildebrand, G. E., Preparation of microparticles by micromixers: characterization of oil/water process and prediction of particle size, Pharmaceutical Research 22 (2), 276-284, 2005

 

(187)Souto, E. B., Anselmi, C., Centini, M., Müller, R. H., Preparation and characterization of N-dodecyl-ferulate-loaded solid lipid nanoparticles (SLN), Int. J. Pharm. 295, 261-268, 2005

 

(188)Göppert, T. M., Müller, R. H., Polysorbate-stabilized solid lipid nanoparticles as colloidal carriers for intravenous targeting of drugs to the brain: Comparison of plasma protein adsorption patterns, Journal of Drug Targeting 13 (3), 179-187, 2005

 

(189)Junghanns, J.-U., Jacob, R., Müller, R. H., Overcoming solubility problems – a convenient way, NewDrugs 3, 10-11, 2005

 

(190)Göppert, T. M., Müller, R. H., Protein adsorption patterns on poloxamer- and poloxamine-stabilized solid lipid nanoparticles (SLN), Eur. J. Pharm. Biopharm. 60, 361-372, 2005

 

(191)Zimmermann, E., Souto, E. B., Müller, R. H., Physicochemical investigations on the structure of drug-free and drug-loaded solid lipid nanoparticles (SLN^TM) by means of DSC and ¹H-NMR, Die Pharmazie 60, 508-513, 2005

 

(192)Göppert, T., Müller, R. H., Adsorption kinetics of plasma proteins on solid lipid nanoparticles for drug targeting, Int. J. Pharm. 302, 172-186, 2005

 

(193)Souto, E. B., Gohla, S. H., Müller, R. H., Rheology of nanostructured lipid carriers (NLC) suspended in viscoelastic medium, Die Pharmazie 60, 671-673, 2005

 

(194)Üner, M., Wissing, S. A., Yener, G., Müller, R. H., Skin moisturizing effect and skin penetration of ascorbyl palmitate entrapped in solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) incorporated in hydrogel, Die Pharmazie 60, 751-755, 2005

 

(195)Üner, M., Wissing, S. A., Yener, G., Müller, R. H., Solid lipid nanoparticles (SLN) and nanostructured lipid carries (NLC) for application of ascorbyl palmitate, Die Pharmazie 60, 577-582, 2005

 

(196)Saupe, A., Wissing, S. A., Lenk, A., Schmidt, C., Müller, R. H., Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) – strucutral investigations on two different carrier systems, Bio-Medical Material and Engineering 15, 393-402, 2005

 

(197)Rank, F., Scheuermann, H.-J., Wozniewski, T., Müller, R. H., Managing compliance in the production – insights and comparisons in chemical-pharmaceutical companies, PDA Journal of Pharmaceutical Science and Technology, 233-239, 2005

 

(198)Souto, E. B., Müller, R. H., SLN and NLC for topical delivery of ketoconazole, Journal of Microencapsulation 22 (5), 501-510, 2005

 

(199)Hernandez-Trejo, N., Kayser, O., Steckel, H., Müller, R. H., Characterization of nebulized buparvaquone nanosuspensions – effect of nebulization technology, Journal of Drug Targeting 13 (8-9), 499-507, 2005

 

(200)Tamilvanan, S., Schmidt, S., Müller, R. H., Benita, S., In vitro adsorption of plasma proteins onto the surface (charges) modified-submicron emulsions for intravenous administration, Eur. J. Pharm. Biopharm. 59, 1-7, 2005

 

(201)Weyhers, H., Lück, M., Mehnert, W., Souto, E. B., Müller, R. H., Surface modified Solid Lipid Nanoparticles (SLN) analysis of plasma protein adsorption patterns by two-dimensional polyacrylamide gel electrophoresis (2-D PAGE), International Journal of Molecular Medicine and Advance Sciences 1 (2), 196-201, 2005

 

(202)Işcan, Y, Wissing, S. A., Hekimoğlu, S., Müller, R. H., Solid lipid nanoparticles (SLN) for topical drug delivery: incorporation of the lipophilic drugs deet and vitamin K, Die Pharmazie 60 (12), 905-909, 2005

 

(203)Radtke, M., Souto, E. M., Müller, R. H., Nanostructured Lipid Carriers (NLC) - The novel generation of solid lipid drug carriers, Pharmaceutical Technology Europe 17 (4), 45-50, 2005

 

(204)Mocha, D., Scheuermann, H.-J., Skuballa, B., Ottnad, M., Wozniewski, T., Müller, R. H., Integration von internen Qualitäts-, Sicherheits- und Umweltschutzaudits in Pharmazeutischen Unternehmen, 1. Schnittstellenanalyse, Pharm.Ind. 67 (9), 1023-1030, 2005

 

(205)Mocha, D., Scheuermann, H.-J., Skuballa, B., Ottnad, M., Wozniewski, T., Müller, R. H., Integration von internen Qualitäts-, Sicherheits- und Umweltschutzaudits in Pharmazeutischen Unternehmen, 2. Konzeptionierung von Integrationsmodellen, Pharm.Ind. 67 (10), 1148-1152, 2005

 

(206)Mocha, D., Scheuermann, H.-J., Skuballa, B., Ottnad, M., Wozniewski, T., Müller, R. H., Integration von internen Qualitäts-, Sicherheits- und Umweltschutzaudits in Pharmazeutischen Unternehmen, Phase 2 – Praktische Implementierung gemeinsamer Qualitäts-, Sicherheits- und Umweltschutzaudits, Pharm.Ind. 67 (11), 1277-1281, 2005

 

(207)Rank, F., Steven, W., Scheuermann, H.-J., Wozniewski, T., Müller, R. H., Mangement Tools for the Evaluation of Compliance and Costs in the Production of Chemical-Pharmaceutical Companies, Quality Assurance Journal 9 (3), 186-191, 2005

 

(208)Souto, E. B., Müller, R. H., The use of SLN and NLC as topical particulate carriers for imidazole anifungal agents, Die Pharmazie 61, 431-437, 2006

 

(209)Weyhers, H., Ehlers, S., Hahn, H., Souto, E. B., Müller, R. H., Solid lipid nanoparticles (SLN) – effects of lipid composition on in vitro degradation and in vivo toxicity, Die Pharmazie 61, 539-544, 2006

 

(210)Lemarchand, C., Gref, R., Passirani, C., Garcion, E., Petri, B., Müller, R. H., Costantini, D., Couvreur, P., Influence of polysaccharide coating on the interactions of nanoparticles with biological systems, Biomaterials 27 (1), 108-118, 2006

 

(211)Müller, R. H., Runge, S., Ravelli, V., Mehnert, M., Thünemann, A. F., Souto, E. B., Oral bioavailability of cyclosporine: solid lipid nanoparticles (SLN) versus drug nanocrystals, Int. J. Pharm. 317, 82-89, 2006

 

(212)Möschwitzer, J., Müller, R. H., New method for the effective production of ultrafine drug nanocrystals, Journal of Nanoscience and Nanotechnology 6, 3145-3153, 2006

 

(213)Weyhers, H. Löbenberg, R., Mehnert, W., Souto, E. B., Kreuter, J., Müller, R. H., In vivo distribution of ¹²⁵l-radiolabelled Solid Lipid Nanoparticles (SLN), Pharm.Ind. 68 (7), 889-894, 2006

 

(214)Lai, F., Wissing, S. A., Müller, R. H., Fadda, A. M., Artemisia arborescens L essential oil-loaded solid lipid nanoparticles for potential agricultural application: preparation and characterisation, AAPS PharmSciTech z, 2006

 

(215)Souto, E. B., Mehnert, W., Müller, R. H., Polymorphic behaviour of Compritol® 888 ATO as bulk lipid and as SLN and NLC, Journal of Microencapsulation 23 (4), 417-433, 2006

 

(216)Keck, C. M., Müller, R. H., Drug nanocrystals of poorly soluble drugs produced by high pressure homogenisation, Eur. J. Pharm. Biopharm. 62, 3-16, 2006

 

(217)Souto, E. B., Müller, R. H., Investigation of the factors influencing the incorporation of clotrimazole in SLN and NLC prepared by hot high-pressure homogenisation, Journal of Microencapsulation 23 (4), 377-388, 2006

 

(218)Möschwitzer, J., Müller, R. H., Spray coated pellets as carrier system for mucoadhesive drug nanocrystals, Eur. J. Pharm. Biopharm. 62, 282-287, 2006

 

(219)Souto, E. B., Müller, R. H., Gohla, S., A novel approach based on lipid nanoparticles (SLN) for topical delivery of α-lipoic acid, Journal of Microencapsulation 22 (6), 581-592, 2006

 

(220)Souto, E. B., Müller, R. H., Applications of Lipid Nanoparticles (SLN and NLC) in Food Industry, Journal of Food Technology 4 (1), 90-95, 2006

 

(221)Geßner, A., Paulke, B.-R., Müller, R. H., T. M. Göppert, Protein rejecting properties of PEG-grafted nanoparticles: Influence of PEG-chain length and surface density evaluated by two-dimensional electrophoresis and bicinchoninic acid (BCA)-proteinassay, Die Pharmazie 61, 293-297, 2006

 

(222)Radomska-Soukharev, A., Müller, R. H., Chemical stability of lipid excipients in SLN – production of test formulations, characterisation and short-term stability, Die Pharmazie 61, 425-430, 2006

 

(223)Cengiz, E., Wissing, S. A., Müller, R. H., Yazan, Y., Sunblocking efficiency of various TiO₂-loaded solid lipid nanoparticle formulations, International Journal of Cosmetic Science, 28, 371-378, 2006

 

(224)Krickau, D. P., Müller, R. H., Thomsen, J., Degradation kinetics of hydrolytically susceptible drugs in o/w emulsions – effects of interfacial area and lecithin, Int. J. Pharm. 342, 62-71, 2007

 

(225)Teeranachaideekul, V., Souto, E. B., Junyaprasert, V. B., Müller, R. H., Cetyl palmitate-based NLC for topical delivery of coenzyme Q₁₀ – development, physicochemical characterization and in vitro release studies, Eur. J. Pharm. Biopharm. 67, 141-148, 2007

 

(226)Petri, B., Bootz, A., Khalansky, A., Hekmatara, T., Müller, R. H., Uhl, R., Kreuter, J., Gelperina, S., Chemotherapy of brain tumour using doxorubicin bound to surfactant-coated poly (butyl cyanoacrylate) nanoparticles: revisiting the role of surfactants, J. Control. Rel. 117, 51-58, 2007

 

(227)Müller, R. H., Petersen, R. D., Hommoss, A., Pardeike, J., Nanostructured Lipid Carriers (NLC) in Cosmetic Dermal Products, Advanced Drug Delivery Reviews (ADDR) 59, 522-530, 2007

 

(228)Walzer, A., Tiemann, F., Knäblein, J., Gerbling, K.-P., Müller, R. H., Bunte, T., Rapid diagnostic method for quantitative testing of < 100 microbes in water, Journal of Pharmaceutical Science & Technology 61 (5), 411-420, 2007

 

(229)Teeranachaideekul, V., Müller, R. H., Junyaprasert, V. B., Encapsulation of ascorbyl palmitate in nanostructured lipid carriers (NLC) – Effects of formulation parameters on physiochemical stability, Int. J. Pharm. 340, 198-206, 2007

 

(230)Xia, Q., Saupe, A., Souto, E. B., Müller, R. H., Nanostructured lipid carriers (NLC) as a novel carrier for sunscreen formulations, Int. J. Cosmet. Sci. 29, 473-482, 2007

 

(231)Müller, R. H., Lipid nanoparticles: recent advances, Advanced Drug Delivery Reviews (ADDR) 59, 375-376, 2007

 

(232)Walsh, G., Müller, R. H., The pharmaceutical biotechnology content of pharmacy programs within Europe: a survey, Journal of Science Education and Technology, Pharmacy Education 7 (1), 27-33, 2007

 

(233)Pardeike, J., Müller, R. H., Coenzyme Q10-loaded NLCs: preparation, occlusive properties and penetration enhancement, Pharmaceutical Technology Europe 19, 46-49, 2007

 

(234)Souto, E. B., Almeida, A. J., Müller, R. H., Lipid nanoparticles (SLN, NLC) for cutaneous drug delivery: structure, protection & skin effects, Journal of Biomedical Nanotechnology, 2007

 

(235)Souto, E. B., Müller, R. H., Rheological and in vitro release behaviour of clotrimazole-containing aqueous SLN dispersions and commercial creams, Die Pharmazie 62, 505-509, 2007

 

(236)Keck, C. M., Hommoss, A. H., Müller, R. H., Lipid nanoparticles for encapsulation of actives: dermal & oral formulations, American Pharmaceutical Review, 2007

 

(237)Souto, E. B., Müller, R. H., Almeida, J. A., Topical delivery of oily actives using solid lipid particles, Pharmaceutical Technology Europe 19 (12), 2007

 

(238)Junghanns, J.-U., Buttle, I., Müller, R. H., Araújo, I. B., Silva, A. K. A., Egito, E. S. T., Damasceno, B. P. G. L., SolEmuls technology: A way to overcome the drawback of parenteral administration of insoluble drugs, Pharmaceutical Development and Technology 12 (5), 437-445, 2007

 

(239)Keck, C. M., Müller, R. H., Size analysis of submicron particles by laser diffractometry – 90 % of the published measurements are false, Int. J. Pharm. 355, 150-163, 2008

 

(240)Teeranachaideekul, V., Junyaprasert, V. B., Souto, E. B., Müller, R. H., Development of ascorbyl palmitate nanocrystals applying the nanosuspension technology, Int. J. Pharm. 354, 227-234, 2008

 

(241)Junghanns, J.-U., Müller, R. H., Nanocrystal technology, drug delivery and clinical applications, International Journal of Nanomedicine, Vol. 3, 295-309, 2008

 

(242)Gramdorf, S., Hermann,  S., Hentschel, A., Schrader, K., Müller, R. H., Kumpugdee-Vollrath, M., Kraume, M., Crystallized miniemulsions: influence of operating parameters during high pressure homogenization on size and shape of particles, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 108-113, 2008

 

(243)Zietze, S., Müller, R. H., Brecht, R., Standardization, evaluation and early-phase method validation of an analytical scheme for batch-consistency N-glycosylation analysis of recombinant produced glycoproteins, Eur. J. Pharm. Biopharm. 68, 818-827, 2008

 

(244)Müller, R. H., Runge, S. A., Ravelli, V., Thünemann, A. F., Mehnert, W., Souto, E. B., Cyclosporine-loaded solid lipid nanoparticles (SLN): drug-lipid physicochemical interactions and characterization of drug incorporation, Eur. J. Pharm. Biopharm. 68, 535-544, 2008

 

(245)Souto, E. B., Müller, R. H., Cosmetic features and applications of lipid nanoparticles (SLN, NLC) Int. J. Cosmet. Sci. 30, 157-165, 2008

 

(246)Müller, R. H., Maincent, P., Muchow, M., Lipid Nanoparticles with a solid matrix (SLN®, NLC®, LDC®) for oral drug delivery, Drug Development and Industrial Pharmacy 34, 1394-1405, 2008

 

(247)Keck, C., Kobierski, S., Mauludin, R., Müller, R. H., Second generation of drug nanocrystals for delivery of poorly soluble drugs: smartCrystals technology, Dosis 2, 124-128, 2008

 

(248)Hentschel, A., Gramdorf, S., Müller, R. H., Kurz, T., β-Carotene loaded nanostructured lipid carriers, Journal of Food Science 73 (2), N1-N6, 2008

 

(249)Teeranachaideekul, V., Boonme, P., Souto, E., Müller, R. H., Junyaprasert, V. B., Influence of oil content on physicochemical properties and skin distribution on Nile red-loaded NLC, J. Control. Rel. 128, 134-141, 2008

 

(250)Teeranachaideekul, V., Souto, B. E., Müller, R. H., Junyaprasert, V. B., Physicochemical characterization and in vitro release studies of ascorbyl palmitate-loaded semi-solid nanostructured lipid carriers (NLC gels), Journal of Microencapsulation 25 (2), 111-120, 2008

 

(251)Pardeike, J., Hommoss, A., Müller, R. H., Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products, Int. J. Pharm. 366, 170-184, 2009

 

(252)Mauludin, R., Müller, R. H., Keck, C. M., Kinetic solubility and dissolution velocity of rutin nanocrystals, Eur. J. of Pharm. Sciences 36, 502-510, 2009

 

(253)Wang, Q, Sun, A. Y., Pardeike, J., Müller, R. H:, Simonyi, A., Sun, G. Y., Neuroprotective effects of a nanocrystal formulation of sPLA₂ inhibitor PX-18 in cerebral ischemia/reperfusion in gerbils, Brain Research 1285, 188-195, 2009

 

(254)Shubar, H. M., Dunay, I. R., Lachenmaier, S., Dathe, M., Bushrab, N. F., Mauludin, R., Müller, R. H., Fitzner, R., Borner, K., Liesenfeld, O., The role of apolipoprotein E in uptake of atovaquone into the brain in murine acute and reactivated toxoplasmosis, Journal of Drug Targeting 17 (4), 257-267, 2009

 

(255)Kobierski, S., Ofori-Kwakye, K., Müller, R. H., Keck, C. M., Resveratrol nanosuspensions for dermal application – production, characterisation & physical stability, Journal of Pharmacy and Pharmacology, Die Pharmazie 64, 741-747, 2009

 

(256)Mauludin, R., Müller, R. H., Keck, C. M., Development of an oral rutin nanocrystal formulation, Int. J. Pharm. 370, 202-209, 2009

 

(257)Domoki, F., Zimmermann, A., Lenti, L., Tóth-Szüki, V., Pardeike, J., Müller, R. H., Bari, F., Secretory phospholipase A2 inhibitor PX-18 preserves microvascular reactivity after cerebral ischemia in piglets, Microvascular Research 78, 212-217, 2009

 

(258)Pardeike, J., Müller, R. H., Dermal and ocular safety of the new phospholipase A₂ inhibitors PX-18 and PX-13 formulated as drug nanosuspension, Journal of Biomedical Nanotechnology 5, 437-444, 2009

 

(259)Joshi, M., Müller, R. H., Lipid nanoparticles for parenteral delivery of actives, Eur. J. Pharm. Biopharm. 71, 161-172, 2009

 

(260)Mishra, P. R., Al Shaal, L., Müller, R. H., Keck, C. M., Production and characterization of Hesperitin nanosuspensions for dermal delivery, Int. J. Pharm. 371, 182-189 (doi:10.1016/j.ijpharm.2008.12.030), 2009

 

(261)Junyaprasert, V. B., Teeranachaideekul, V. , Souto, E. B., Boonme, P. , Müller, R. H. , Q10-loaded NLC versus nanoemulsions: Stability, rheology and in vitro skin permeation, Int. J. Pharm. 377, 207-214, 2009

 

(262)Muchow, M., Schmitz, E. I., Despatova, N., Maincent, P., Müller, R. H., Omega-3 fatty acids-loaded lipid nanoparticles for patient-convenient oral bioavailability enhancement, Die Pharmazie 64 (8), 499-504, 2009

 

(263)Pardeike, J., Schwabe, K., Müller, R. H., Influence of nanostructured lipid carriers (NLC) on the physical properties of the Cutanova Nanorepair Q10 cream and the in vivo skin hydration effect, Int. J. Pharm. 396, 166-173, 2010

 

(264)Pardeike, J., Müller, R. H., Nanosuspensions: A promising formulation for the new phospholipase A₂ inhibitor PX-18, Int. J. Pharm. 391, 322-329, 2010

 

(265)Müller, R. H., Keck, C. M., Pharmaceutical nanoparticles – from their innovative origin to their future, Int. J. Pharm. 390, 1-2, 2010

 

(266)Obeidat, W. M., Schwabe, K., Müller, R. H., Keck, C. M., Preservation of nanostructured lipid carriers (NLC), Eur. J. of Pharm. Sciences 76, 56-67, 2010

 

(267)Shegokar, R., Müller, R. H., Nanocrystals: industrially feasible multifunctional formulation technology for poorly soluble actives, Int. J. Pharm. 399, 129-139 (doi:10.1016/j.ijpharm.2010.07.044), 2010

 

(268)Averina, E. S., Seewald, G., Müller, R. H., Radnaeva, L. D., Popov, D. V., Nanostructured lipid carriers (NLC) on the basis of Siberian pine (pinus sibirica) seed oil, Die Pharmazie 65, 25-31, 2010

 

(269)Al Shaal, L., Müller, R. H., Keck, C. M., Preserving hesperetin nanosuspensions for dermal application, Die Pharmazie 65 (2), 86-92 (doi:10.1691/Ph.2010.9214), 2010

 

(270)Al Shaal, L., Müller, R. H., Shegokar, R., smartCrystal combination technology – scale up from lab to pilot scale and long term stability, Die Pharmazie 65, 877–884 (doi:10.1691/Ph.2010.0181, 2010

(271)Shegokar, R., Singh, K. K., Müller, R. H., Production & stability of stavudine solid lipid nanoparticles – from lab to industrial scale, Int. J. Pharm. 416 (2), 461-470 (doi:10.1016/j.ijpharm.2010.08.014), 2011

 

(272)Kasongo, W. K., Shegokar, R., Müller, R. H., Walker, R. B., Formulation development and in vitro evaluation of didanosine-loaded nanostructured lipid carriers for the potential treatment of AIDS dementia complex Didanosine-loaded nanostructured lipid carriers, Drug Development and Industrial Pharmacy 37 (4), 396-407 (doi:10.3109/03639045.2010.516264), 2011

 

(273)Sahoo, N. G., Kakran, M., Al Shaal, L., Li, L., Müller, R. H., Pal, M., Tan, L. P., Preparation and characterization of quercetin nanocrystals, J. Pharm. Sci. 100 (6), 2379-2390 (doi:10.1002/jps.22446), 2011

 

(274)Shegokar, R., Jansch, M., Singh, K. K., Müller, R. H., In vitro protein adsorption studies on nevirapine nanosuspensions for HIV chemotherapy, Nanomedicine: Nanotechnology, Biology and Medicine 7 (3), 333-340 (doi:10.1016/j.nano.2010.10.012), 2011

 

(275)Kasongo, W. K., Jansch, M., Müller, R. H., Walker, R. B., Evaluation of the in vitro differential protein adsorption patterns of didanosine-loaded nanostructured lipid carriers (NLCs) for potential targeting to the brain, Journal of Liposome Research 21 (3), 245-254 (doi:10.3109/08982104.2010.539186) 2011

 

(276)Muchow, M., Maincent, P., Müller, R. H., Keck, C. M., Production and characterization of testosterone undecanoate-loaded NLC for oral bioavailability enhancement, Drug Development and Industrial Pharmacy 37 (1), 8-14 (doi:10.3109/03639045.2010.489559), 2011

 

(277)Kovacevic, A., Savic, S., Müller, R.H., Vuleta, G., Keck, C.M., Polyhydroxy surfactants for the formulation of lipid nanoparticles (SLN and NLC): Effects on the particle size, physical stability and particle matrix structure, Int. J. Pharm. 406, 163-172 (doi:10.1016/j.ijpharm.2010.12.036), 2011

 

(278)Shubar, H., Lachenmaier, S., Heimesaat, M., Lohmann, U., Mauludin, R., Müller, R., Fitzner, R., Borner, K., Liesenfeld, O., SDS-coated atovaquone nanosuspensions show improved therapeutic efficacy against experimental acquired and reactivated toxoplasmosis by improving passage of gastrointestinal and blood-brain barriers, Journal of Drug Targeting 19 (2), 114-124 (doi: 10.3109/10611861003733995), 2011

 

(279)Müller, R. H., Gohla, S., Keck, C. M., State of the Art of Nanocrystals - special features, production, nanotoxicology aspects & intracellular delivery, Eur. J. Pharm. Biopharm. 78 (1), 1-9 (doi:10.1016/j.ejpb.2011.01.007), 2011

 

(280)Mitri, K., Shegokar, R., Gohla, S., Anselmi, C., Müller, R. H., Lipid nanocarriers for dermal delivery of lutein: preparation, characterization, stability and performance, Int. J. Pharm. 414 (1-2), 267-275 (doi:10.1016/j.ijpharm.2011.05.008), 2011

 

(281)Müller, R. H, Shegokar, R., Keck, C. M., 20 Years of Lipid Nanoparticles (SLN, NLC): present state of development & industrial applications, Current Drug Discovery Technologies 8 (3), 207-227 (PMID: 21291409), 2011

 

(282)Bege, N., Renette, T., Jansch, M., Reul, R., Merkel, O., Petersen, H., Curdy, C., Müller, R. H., Kissel, T., Biodegradable Poly(ethylene carbonate) nanoparticles as a promising drug delivery system with „stealth“ potential, Macromolecular Bioscience 11 (7) 897-904 (doi:10.1002/mabi.201000496), 2011

 

(283)Pardeike, J., Schmidt, C., Volz, I., Müller, R.H., NLC as delivery system for the phospholipase A₂ inhibitors PX-18 and PX-13 for dermal application, Die Pharmazie 66 (5), 357-361 (doi:10.1691/ph2011.0339), 2011

 

(284)Kasongo, W. K., Müller, R. H., Walker, R. B., The use of hot and cold high pressure homogenization to enhance the loading capacity and encapsulation efficiency of nanostructured lipid carriers for the hydrophilic antiretroviral drug, didanosine for potential administration to paediatric patients, Pharmaceutical Development and Technology, (doi:10.3109/10837450.2010.542163), 2011

 

(285)Kasongo, W. K., Pardeike, J., Müller, R. H., Walker, R. B., Selection and characterization of suitable lipid excipients for use in the manufacture of didanosine-loaded solid lipd nanoparticles and nanostructured lipid carriers, Journal of Pharmaceutical Sciences 100 (12), 5185-5196 (doi:10.1002/jps.22711), 2011

 

(286)Al Shaal, L., Shegokar, R., Müller, R. H., Production and characterization of anti-oxidative apigenin nanocrystals as novel UV skin protective formulation, Int. J. Pharm. 420 (1), 133-140 (doi:10.1016/j.ijpharm.2011.08.018), 2011

 

(287)Mitri, K., Shegokar, R., Gohla, S., Anselmi, C., Müller, R. H., Lutein nanocrystals as antioxidant formulation for oral and dermal delivery, Int. J. Pharm. 420 (1), 141-146 (doi:10.1016/j.ijpharm.2011.08.026), 2011

 

(288)Shegokar, R., Singh, K. K., Müller, R. H., Nevirapine nanosuspension: comparative investigation of production methods, Nanotechnology Development (doi:10.4081/nd.2011.e4), 2011

 

(289)Nikolic, S., Gohla, S., Müller. R. H., Lipid nanoparticles: nanocarriers for more effective and safer photoprotective products, Expert Review of dermatology 6 (5), 501-507 (doi:10.1586/edm.11.56), 2011

 

(290)Doktorovova, S., Shegokar, R., Rakovsky, E., Gonzales-Mira, E., Silva, A. M., Lopes, C. M., Martins-Lopes, P., Müller, R. H., Souto, E. B., Cationic solid lipid nanoparticles (SLN) – correlation of structure with stability and DNA binding capacity, Int. J. Pharm. 420 (2), 341-349 (doi:10.1016/j.ijpharm.2011.08.042), 2011

 

(291)Müller, R. H., Keck, C. M., Twenty Years Drug nanocrystals – where we are, and where to go? Eur. J. Pharm. Biopharm. (doi:10.1016/j.ejpb.2011.09.012), 2011, in press

 

(292)Kakran, M., Sahoo, N. G., Shegokar, R., Al Shaal, L., Li, L., Müller, R. H., Fabrication of quercetin nanocrystals: comparison of different methods, Eur. J. Pharm. Biopharm. (doi:10.1016/j.ejpb.2011.08.006), 2011, in press

 

(293)Müller, R. H., Harden, D., Keck, C. M., Development of industrially feasible concentrated 30% and 40% nanoemulsion for intravenous drug delivery, Drug Development and Industrial Pharmacy (doi:10.3109/03639045.2011.608681), 2011

 

Non-refereed papers:

 

(1)   Müller, R. H., Moderne Partikelmeßmethoden und ihre Anwendung in der Pharmazie, Teil 1: Mikroskopie und Weißlichtmessungen, Pharmazeutische Verfahrenstechnik heute 1, (12), 87-89, 1983

 

(2)   Müller, R. H. , Moderne Partikelmeßmethoden und ihre Anwendung in der Pharmazie Teil 2: Meßverfahren unter Verwendung von Laserlicht, Pharmazeutische Verfahrenstechnik heute 1, (13), 91-94, 1983

 

(3)   Müller, B. W. ,Müller, R. H., Bestimmung von mittleren Durchmessern und Größenverteilung an Teilchen im submikroskopischen Bereich mit der Photonenkorrelationsspektroskopie, Pharmazeutische Industrie 45, (11), 1150-1153, 1983

 

(4)   Müller, R. H., Merz, J., Moderne Meßmethoden zur Bestimmung der Teilchenladung, Teil 1, Pharmazeutische Verfahrenstechnik heute 1, (20), 137-140, 1984

 

(5)   Müller, R. H. und Merz, J., Moderne Meßmethoden zur Bestimmung der Teilchenladung, Teil 2, Pharmazeutische Verfahrenstechnik heute 1, (21), 141-144, 1985

 

(6)   Müller, R. H., Heinemann, S., Drug Targeting. Kolloide Carrier zur intravenösen Applikation - Wunschtraum oder realistische Chance?, Deutsche Apotheker Zeitung 129 (41), 2188-2193, 1989

 

(7)   Müller, B. W., Lucks, J. S., Stampa, B. und Müller, R. H., Effect of Anti-flocculants on Suspension Stability and Size Distribution - An investigation by laser light scattering techniques, Pharm. Ind. 52 (6), 789-793, 1990

 

(8)   Müller, R. H., Heinemann, S., Smal, R., Stabilitätsbestimmung von Fettemulsionen zur parenteralen Ernährung, Deutsche Apotheker Zeitung 130 (6), 282-284, 1990

 

(9)   Müller, R. H., Heinemann, S., Smal, R., Bestimmung der Organverteilung von Arzneiformen und Wirkstoffen durch Gamma-Szintigraphie, Deutsche Apotheker Zeitung 130 (8), 404-406, 1990

 

(10) Müller, R. H., Herbort, J., Lherm, C., Couvreur, P., Nanopartikel: Gewebsspezifische Arzneiform für Zytostatika, Deutsche Apotheker Zeitung 130 (27), 1509-1511, 1990

 

(11) Müller, R. H., Herbort, J., Smal, R., Heinemann, S., Latices: Polymerpartikel für Forschung und Arzneimittelherstellung, Deutsche Apotheker Zeitung 130 (21), 1210-1211, 1990

 

(12) Bräuer, A., Müller, R. H., Zellkulturen: Hepatozyten als In-vitro-Testsystem, Deutsche Apotheker Zeitung 130 (25), 1404-1405, 1990

 

(13) Müller, R. H., Herbort, J., Couvreur, P., Chiannilkulchai, N., Optimierung von Zytostatika-Formulierungen, Deutsche Apotheker Zeitung 131 (36), 1836-1837, 1991

 

(14) Müller, R. H., Waßmus, W., Smal, R., Koosha, F., Mikropartikel: Mikrodepots zur kontrollierten Arzneistoffabgabe, Deutsche Apotheker Zeitung 131 (40), 2049-2051, 1991

 

(15) Rudt, S., Smal, R., Müller, R. H., Chemilumineszenz-Assay: Untersuchung der Phagozytose von Arzneistoffträgern, Deutsche Apotheker Zeitung 132 (1/2), 10-11, 1992

 

(16) Rudt, S., Blunk, T., Müller, R. H., Quantification of Cell Subpopulations, Fractions of Dead Cells and Debris in Cell Suspensions by Laser Diffractometry, Pharm. Ind. 54 (11), 966-969, 1992

 

(17) Blunk, T. Mak, E., Müller, R. H., Characterization of Colloidal Drug Carriers: Determination of surface hydrophobicity by hydrophobic interaction chromatography, Pharm. Ind. 55 (6), 612-615, 1993

 

(18) Wallis, K. H., Müller, R. H., Determination of the Surface Hydrophobicity of Colloidal Dispersions by Mini-Hydrophobic Interaction Chromatography, Pharm. Ind. 55 (12), 1124-1128, 1993

 

(19) Wallis, K. H., Müller, R. H., Comparative Measurements of Nanoparticle Degradation Velocity using an Accelerated Hydrolysis Test, Pharm. Ind. 55 (2), 168-170, 1993

 

(20) Müller, R.H., Heinemann, S., Emulsions for Intravenous Administration. I. Emulsions for nutrition and drug delivery, Pharm. Ind. 55 (9), 853-856, 1993

 

(21) Müller, R.H., Heinemann, S., Emulsions for Intravenous Application. II. Destabilisation and stabilisation mechanisms in fat emulsions, Pharm. Ind. 55 (10), 948-953, 1993

 

(22) Schuhmann, R., Mehnert, W., Müller, R.H., Coulter Counter Based Coalescence Assay for the Determination of Emulsion Stability after Addition of Electrolyte, Pharm. Ind. 55 (7), 701-704, 1993

 

(23) Rudt, S., Müller, R.H., Messung der Chemilumineszenz zur Analytik und In-vitro-Testung von Arzneiformen, Pharm. Ind.56 (4), 393-396, 1994

 

(24) Diederichs, J. E, Müller, R. H., Liposome in Kosmetika und Arzneimitteln, Pharm. Ind. 56 (3), 267-275, 1994

 

(25) Huber, G.M.W., Becker, R., Müller, R.H., Zusammenhang zwischen Fließeigenschaften und Oberfläche pulverförmiger Rezepturen, Pharm. Ind. 56 (4), 389-392, 1994

 

(26) Müller, R.H., Paulke, B.-R., Kolloide als Arzneistoffträger in der Medizin,.Spektrum der Wissenschaft, 102-106, 1994

 

(27) Müller, R.H., Mehnert, W., Neue Arzneimittel mit Nanopartikeln - Innovationen in der Pharmazeutischen Technologie, Deutsche Apotheker Zeitung 135, 2597-2601, 1995

 

(28) Schuhmann, R., Müller, R.H., Analytik disperser Systeme mit Streulichtverfahren, Pharm. Ind., 57 (7), 579-584, 1995

 

(29) Schuhmann, R., Müller, R.H., Analytik disperser Systeme mit Streulichtverfahren, Österreichische Chemie 96, 198-203, 1995 (Nachdruck von Nr. 28)

 

(30) Schuhmann, R., Müller, R.H., Analytik disperser Systeme mit Streulichtverfahren, Chemie-Plus 1/2, 53-58, 1996 (Nachdruck von Nr. 28)

 

(31) Weyhers, H., Mehnert, W., Müller, R.H., Analysis of Particle Size Distribution of Micronized Lactose by Laser Diffractometry, Pharm. Ind. 58 (4), 354-357, 1996

 

(32) Schütt, D., Schuhmann, R., Müller, R.H., Genauer durch Mehrwinkelanalyse - Teilchengrößenmessung im Submikronbereich, Chemie-Technik 9, 18-20, 1996

 

(33) Weyhers, H., Mehnert, W., Müller, R.H., Analysis of Particle Size Distribution of Micronized Lactose by Laser Diffractometry, Drugs made in Germany 40 (2), 1997 (Nachdruck von Nr. 31)

(34) Müller, R. H., Runge, S. A., Celowane podanie leku za pomoca koloidalnych nosników, Roczniki Naukowe, 1997

(35) Müller, R. H., Dingler, A., Feste Lipid-Nanopartikel (Lipopearls™) als neuartiger Carrier für kosmetische und dermatologische Wirkstoffe, Pharmazeutische Zeitung 49, Dermopharmazie, 11-15, 1998

(36) Müller, R. H., Dingler, A., The next generation after the liposomes: solid lipid nanoparticles (SLN™, Lipopearls™) as dermal carrier in cosmetics, Eurocosmetics 7/8, 19-26, 1998

(37) Müller, R. H., Harnisch, S., Characterization of fish vaccines and testing of administration properties, Bull. Eur. Ass. Fish Pathol. 18 (6), 209-219, 1998

 

(38) Müller, R. H., Olbrich, C., Solid Lipid Nanoparticles (SLN): Phyagocytic uptake, in vitro cytotoxity and in vivo biodegradation, Drugs made in Germany 42 (2), 49-53, 1999

 

(39) Kayser, O., Müller, R. H., Pharmazeutische Biotechnologie, Deutsche Apotheker Zeitung 139 (45), 4339-4343, 1999

 

(40) Müller, R. H., The European Association of Pharma Biotechnology Satellite Meeting, Idrugs 3 No. 11, 2000

 

(41) Müller, R. H., Lipid-Nanopartikel (SLN, NLC) zur Verkapselung von kosmetischen Wirkstoffen, Kosmetikjahrbuch, 481-484, 2003

 

(42) Müller, R. H., Souto, E. B., Gohla, S., Lipid nanoparticles (Nanopearls): A novel cosmetic carrier, SÖFW Journal 130 (9), 36-45, 2004

 

(43) Müller, R. H., Souto, E. B., Gohla, S., Nanopearls – The novel carrier generation after liposomes, COSSMA 2, 26-27, 2005

 

(44) Müller, R. H., Souto, E. B., Gohla, S., Nanopearls – the novel carrier system for cosmetic application, Eurocosmetics 3, 22-26, 2005

 

(45) Rimpler, M., Müller, R. H., Hommoss, A., Schwabe, K., Lipophiler Wirkstoff durch NLC-Technologie, Eurocosmetics 11/12, 2-5, 2005

 

(46) Petersen, R.-D., Hommoss, A., Peter, M., Müller, R. H., Nanostructured Lipid Carrier – a delivery sytem with protective functions, SÖFW Journal 132 (4), 64-69, 2006

 

(47) Müller, R. H., Pardeike, J., Petersen, R., Hommoss, A., Nano Lipid Carriers (NLC): the new cosmetic carrier generation, SÖFW Journal 133 (5), 14-21, 2007

 

(48) Müller, R. H., Hommoss, A., Pardeike, J., Schmidt, C., Lipid nanoparticles (NLC) as novel carrier for cosmetics – special features & state of commercialisation, SÖFW Journal 133 (9), 40-48, 2007

 

(49) Müller, R. H., Rimpler, C., Petersen, R., Hommoss, A., Schwabe, K., A new dimension in cosmetic products by nanostructured lipid carriers (NLC) technology, Eurocosmetics 3, 2-7, 2007

 

(50) Müller, R. H., Rimpler, C., Hommoss, A., Schwabe, K., Nanotechnologie in der Kosmetik – der aktuellste Trend, Kosmetik International 5, 2007

 

(51) Müller, R. H., Immig, H., Hommoss, A., Prolonged release of perfumes by nano lipid carriers (NLC) technology, Eurocosmetics 11/12, 8-11, 2007

 

(52) Keck, C., Müller, R. H., Nanodiamanten – Erhöhte Bioaktivität. Wirkstoffe im Nanometerbereich verhelfen zur besseren Wirkung, Labor&More 1, 64-65, 2008

 

(53) Keck, C. M., Müller, R. H., Lipid nanoparticles – the innovative successor generation of the liposomes? Indian Local Chapter, CRS Newsletter, 7-12, 2008

 

(54) Junghanns, J.-U., Müller, R. H., Herstellung und klinische Anwendung nanokristalliner Wirkstoffe, PZ-Prisma 2, 101-110, 2008

 

(55) Keck, C., Müller, R. H., Lipidnanopartikel – “Nanotaxis” für den dermalen Wirkstofftransport, Labor&More 4,10-11, 2009

 

(56) Keck, C. M., Müller, R. H., Silber-Lipid-Zwerge. Ein neues Therapiekonzept gegen Neurodermitis, Quantos 1, 6-11, 2010

 

(57) Keck, C. M., Klotz, M., Schäfer, K.-H., Müller, R. H., Proteinanalytik - Der Schlüssel zum Körper: Essentielles Tool für Design moderner Biomaterialien und Drug Delivery Systeme, Labor&More 1, 52-55, 2011

 

 

 

Proceedings:

 

(1)   Müller, R. H., Müller, B. W. Davis, S. S., Amplitude Weighted Phase Structuration - a new Method for Simultaneous Charge and Size Determination of Colloidal Drug Carriers, Proceed. 4th International Conf. on Pharmaceutical Technology, 03. - 05.06. Paris, Vol. I, 205-214, 1986

 

(2)   Müller, R. H., Davis, S. S., Illum, L. Mak, E., Surface Characterisation of Colloidal Drug Carriers Coated with Polymers, Macromolecular Reprints, 161-162, 1986

 

(3)   Davies, M. C., Wright, J., Koosha, F., Müller, R. H., Davis, S. S., Surface Chemical Analysis and Site-Specific Delivery, Proceed. Int. Symp. Control. Rel. Bioact. Mater. 14, 111-112, 1987

 

(4)   Müller, R. H., Heinemann, S. Niemann, W., Stability Determination of Parenteral Emulsions - a Comparison of Conventional and Laser Light Scattering Techniques, J. Pharm. Pharmacol. Suppl., 135, 1987

 

(5)   Koosha, F., Müller, R. H., Washington, C., Production of Polyhydroxybutyrate (PHB) Nanoparticles for Drug Targeting, J. Pharm. Pharmacol. Suppl., 136, 1987

 

(6)   Müller, R. H., Koosha, F., Davis, S. S. Illum, L., In Vitro and in Vivo Release of In-111 from PHB and PLA Nanoparticles, Proceed. Int. Symp. Control. Rel. Bioact. Mater. 15, 378-379, 1988

 

(7)   Müller, R. H., Davis, S. S., Heinemann, S., Long-Term Stability of Regimens for Total Parenteral Nutrition, J. Pharm. Pharmacol. Suppl., 156, 1988

 

(8)   Lucks, J. S., Müller, B. W., Stampa, B., Davis, S. S., Müller, R. H., Effect of Anti-Flocculants on Stability and Elimination of Aggregates in Suspensions, J. Pharm. Pharmacol. Suppl., 4, 1988

 

(9)   Koosha, F., Müller, R. H., Davis, S. S., A Continous Flow System for In Vitro Evaluation of Drug-Loaded Biodegradable Colloidal Carriers, J. Pharm. Pharmacol. Suppl., 131, 1988

 

(10) Lherm, C., Müller, R. H., Herbort, J., Couvreur, P., Cytotoxicity of Polyalkylcyano­acrylate Particles of Increasing Alkyl Chain Length, 5th Int. Conf. on Pharm. Technol. (APGI) Vol. III, 81-88, 1989

 

(11) Diederichs, J. E., Weyhers, H., Müller, R. H., Parenteral fat emulsions I. Effects of emulsion composition on the microviscosity of the emulsifier film, Int. Symp. Control. Rel. Bioact. Mater. 18, 471-472, 1991

 

(12) Müller, R. H., Heinemann, S., Diederichs, J. E., Parenteral fat emulsions II: Charge and rigidity of emulsifier film related to the long-term stability, Int. Symp. Control. Rel. Bioact. Mater. 18, 469-470, 1991

 

(13) Müller, R. H., Rudt, S., Optimization of a chemiluminescence based cell culture assay to study the affinity of surface-modified drug carriers to macrophages, Int. Symp. Control. Rel. Bioact. Mater. 18, 219-220, 1991

 

(14) Carstensen, H., Müller, B. W., Müller, R. H., Characterization of the properties of parenteral fat emulsions related to their uptake by the RES, Int. Symp. Control. Rel. Bioact. Mater. 18, 473-474, 1991

 

(15) Lucks, J. S., Herbort, J., Chiannilkulchai, N., Müller, B. W., Couvreur, P., Müller, R. H., Water-soluble metallocene derivatives as antitumor agents - reduced in vivo toxicity of slowly decomposing complexes, Int. Symp. Control. Rel. Bioact. Mater. 18, 419-420, 1991

 

(16) Bock, T., Müller, R. H., Müller, B. W., A new assay for determining the hemolytic activity of drugs incorporated in emulsions and liposomes, 6th Int. Conf. on Pharm. Technol. (APGI), Vol. VI, 380-387, 1992

 

(17) Diederichs, J. E., Mehnert, W., Lucks, J. S., Müller, R. H., Microviscosity measurements for the optimization of liposomes and emulsion formulations, 6th Int. Conf. on Pharm. Technol. (APGI), Vol. V, 138-147, 1992

 

(18) Lucks, J. S., Diederichs, J. E., Müller, B. W., Müller, R. H., Preparation and stability of sterically stabilized soya oil emulsions, 6th Int. Conf. on Pharm. Technol. (APGI), Vol. V, 148-153, 1992

 

(19) Lucks, J. S., Baratt, G., Müller, B. W., Couvreur, P., Müller, R. H., Targeted controlled release formulations of titanocene dichloride for the treatment of liver metastasis, 6th Int. Conf. on Pharm. Technol. (APGI), Vol. II, 317-321, 1992

 

(20) Müller, R. H., Lucks, J. S., Diederichs, J. E., Heinemann, S., Egg lecithin stabilized emulsions for parenteral nutrition - a three year stability study, 6th Int. Conf. on Pharm. Technol. (APGI),  Vol. IV, 351-360, 1992

 

(21) Diederichs, J. E., Mehnert, W., Müller, R. H., Differential Scanning Calorimetry of parenteral fat emulsions, 6th Int. Conf. on Pharm. Technol. (APGI), Vol. IV, 361-369, 1992

 

(22) Müller, R. H., Blunk, T., Carstensen, H., Müller, B. W., Comparison of the physicochemical properties of surface-modified colloidal drug carriers and fat emulsions for intravenous injection, 6th Int. Conf. on Pharm. Technol. (APGI), Vol. V, 174-184, 1992

 

(23) Blunk, T., Hochstrasser, D. F., Müller, B.W., Müller, R.H., Differential adsorption: Effect of plasma protein adsorption patterns on organ distribution of colloidal drug carriers, Int. Symp. Control. Rel. Bioact. Mater. 20, 256-257, 1993

 

(24) Blunk, T., Hochstrasser, D. F., Müller, B.W., Müller, R.H., 2-D PAGE analysis of plasma protein adsorption on colloidal drug carriers, Int. Symp. Control. Rel. Bioact. Mater. 20, 284-285, 1993

 

(25) Diederichs, J.E., Müller, R.H., Microviscosity of bovine surfactant liposomes for the treatment of IRDS, Int. Symp. Control. Rel. Bioact. Mater. 20, 488-489, 1993

 

(26) Diederichs, J.E., Müller, R.H., Production and characterization of bovine surfactant liposomes for the treatment of IRDS, Int. Symp. Control. Rel. Bioact. Mater. 20, 482-483, 1993

 

(27) Müller, R.H., Schwarz, C., Mehnert, W., Lucks, J.S., Production of solid lipid nanoparticles (SLN) for controlled drug delivery, Int. Symp. Control. Rel. Bioact. Mater. 20, 480-481, 1993

 

(28) Maaßen, S., Schwarz, C., Mehnert, W., Lucks, J.S., Yunis-Specht, F., Müller, B.W., Müller, R.H., Comparison of cytotoxicity between polyester nanoparticles and solid lipid nanoparticles (SLN), Int. Symp. Control. Rel. Bioact. Mater. 20, 490-491, 1993

 

(29) Müller, R.H., Schwarz, C., zur Mühlen, A., Mehnert, W., Incorporation of Lipophilic Drugs and Drug Release profiles of Solid Lipid Nanoparticles (SLN), Int. Symp. Control. Rel. Bioact. Mater. 21, 146-147, 1994

 

(30) Blunk, T., Bock, T.K., Hochstrasser, D.F., Sanchez, J.C., Müller, B.W., Müller, R.H., Plasma Protein Adsorption Patterns on Fat Emulsions compared to Modified Latex Particles, Int. Symp. Control. Rel. Bioact. Mater. 21, 503-504, 1994

 

(31) Diederichs, J.E., Vauthier, C., Alphandary, H., Couvreur, P., Müller, R.H., Formation Process and Determination of Microviscosity of Alginate Nanoparticles, Int. Symp. Control. Rel. Bioact. Mater. 21, 511-512, 1994

 

(32) Blunk, T., Lück, M., Hochstrasser, Sanchez, J.C., Müller, B.W., Müller, R.H., Kinetics of Protein Adsorption on Colloidal Drug Carriers for Drug Targeting. Evaluation by HR-Two-Dimensional Polyacrylamide Gel Electrophoresis, Proc. of 2D Electrophoresis: from protein maps to genomes, Siena, Italien, 100-101, 1994

 

(33) Herbort, J., Diederichs, J.E., Müller, R.H., Particle size analysis of liposomes in hydrogels by photon correlation spectroscopy (PCS), 1^st World Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, APGI/APV, Budapest, 555-556, 1995

 

(34) Bucke, W.E., Ehlers, S., Leitzke, S., Diederichs, J.E., Hahn, H., Müller, R.H., Optimized liposomal amikacin for treatment of disseminated mycobacterial infections, 1^st World Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, APGI/APV, Budapest, 545-546, 1995

 

(35) Müller, R.H., Mehnert, W., Potential of Solid Lipid Nanoparticles (SLN) for Controlled Drug Delivery, 1^st World Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, APGI/APV, Budapest, 463-464, 1995

 

(36) Weyhers, H., Ehlers, S.,Mehnert, W.,Hahn, H., Müller, R.H., "Solid Lipid Nanoparticles" - determination of in vivo toxicity, 1^st World Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, APGI/APV, Budapest, 489-490, 1995

 

(37) Rühl, D., Paulke, B.-R., Maurer, H.R., Müller, R.H., Phagocytic uptake of polymeric particles in vitro - effect of surface hydrophobicity and fluorescent labeling, 1^st World Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, APGI/APV, Budapest, 525-526, 1995

 

(38) Eckstein, B., Diederichs, J.E., Burger, J.J., Sloot, E.A., Müller, R.H., Analytical approach to determine the effect of azo dyes on the physical stability of stabilized o/w emulsions, 1^st World Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, APGI/APV, Budapest, 660-661, 1995

 

(39) Müller, R.H., Peters, K., Becker, R., Kruss, B., Nanosuspensions - a novel formulation for the i.v. administration of poorly soluble drugs, 1^st World Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, APGI/APV, Budapest, 491-492, 1995

 

(40) Freitas, C., Lucks, J.S., Müller, R.H., Effect of storage conditions on long-term stability of "Solid Lipid Nanoparticles" (SLN) in aqueous dispersion, 1^st World Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, APGI/APV, Budapest, 493-494, 1995

 

(41) Thode, K., Kresse, M., Pfefferer, D., Semmler, W., Müller, R.H., Mini-HIC for the determination of the surface hydrophobicity of magnetite dispersions, 1^st World Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, APGI/APV, Budapest, 509-510, 1995

 

(42) Kresse, M., Pfefferer, D., Thode, K., Müller, R.H., Semmler, W., Estimation of hydrodynamic sizes of dextran coated iron oxide nanoparticles by size exclusion chromatography (SEC), 1^st World Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, APGI/APV, Budapest, 507-508, 1995

 

(43) Blunk, T., Lück, M., Müller, B.W., Müller, R.H., Influence of polyethylene oxide chains on the protein adsorption on nanoparticles for drug targeting, 1^st World Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, APGI/APV, Budapest, 531-532, 1995

 

(44) Müller, R.H., Peters, K., Becker, R., Kruss, B., Nanosuspensions for the i.v. Administration of Poorly Soluble Drugs - Stability During Sterilization and Long-Term Storage, Int. Symp. Control. Rel. Bioact. Mater. 22, 574-575, 1995

 

(45) Diederichs, J.E., Eckstein, B., Müller, R.H., Influence of Divalent Cations on the Coalescence Kinetics of Parenteral Fat Emulsions - Fusion Properties of Calcium Ions, Int. Symp. Control. Rel. Bioact. Mater. 22, 378-379, 1995

 

(46) Blunk, T., Lück, M., Diederichs, J.E., Müller, B.W., Müller, R.H., Plasma Protein Adsorption on Polystyrene Particles of Different Size Modified with Poloxamer 407, Int. Symp. Control. Rel. Bioact. Mater. 22, 47-48, 1995

 

(47) Schwarz, C., Freitas, C., Mehnert, W., Müller, R.H., Sterilization and Physical Stability of Drug-Free and Etomidate-Loaded Solid Lipid Nanoparticles, Int. Symp. Control. Rel. Bioact. Mater. 22, 766-767, 1995

 

(48) Peters, K., Müller, R.H., Nanosuspensions for the oral application of poorly soluble drugs, Proceeding European Symposium on Formulation of Poorly-available Drugs for Oral Administration, APGI, Paris, 330-333, 1996

 

(49) Müller, R.H., Peters, K., Craig, D., Electron microscopic studies of nanosuspensions - particle shapes as a funktion of drug and surfactant, Int. Symp. Control. Rel. Bioact. Mater. 23, 925-926, 1996

 

(50) Müller, R.H., zur Mühlen, A., Freitas, C., Solid Lipid Nanoparticles (SLN) for intravenous drug delivery, Int. Symp. Control. Rel. Bioact. Mater. 23, 184-185, 1996

 

(51) Diederichs, W.E., Leitzke, J.E., Bucke, S., Borner, K., Ehlers, S., Hahn, H., Müller, R.H., Superiority of Liposomal Amikacin - A comparison with free drug admixed to colloidal carriers, Int. Symp. Control. Rel. Bioact. Mater. 23, 659-660, 1996

 

(52) Schuhmann R., Müller, R.H., Optimierung der Probenaufbereitung für Coulter-Counter-Messungen, Proceedings Seminar mit Praktikum: Probenpräparation und Partikelmeßtechnik, George-Simon-Ohm-Fachhochschule Nürnberg, Fachbereich Verfahrenstechnik und Coulter Electronics GmbH, 25./26.6.1996

 

(53) Pistel, K.F., Lück, M., Müller, R.H. and Kissel, T., Plasma Protein Adsorption on Biodegradable Microspheres Consisting of Polyesters or ABA Triblock Copolymers, Int. Symp. Control. Rel. Bioact. Mater. 24, 765-766, 1997

 

(54) Almeida, A.J., Runge, S., Müller, R.H., Investigations on solid lipid nanoparticles (SLN) as colloidal carriers for protein antigens, Int. Symp. Control. Rel. Bioact. Mater. 24, 837-838, 1997

 

(55) Diederichs, J.E., Herbort, J., Müller, R.H., Long-term stability of liposomes in hydrogels, Int. Symp. Control. Rel. Bioact. Mater. 24, 845-846 (1997)

 

(56) Harnisch, S., Müller, R.H., Analysis of adsorbed plasma proteins on commercial emulsions for parenteral nutrition, Int. Symp. Control. Rel. Bioact. Mater. 24, 847-848, 1997

 

(57) Lück, M, Schröder, W., Paulke, B.-R., Müller, R.H., Identification of plasma proteins adsorbed on polystyrene model particles, Int. Symp. Control. Rel. Bioact. Mater. 24, 849-850, 1997

 

(58) Müller, R.H., Peters, K., Nanosuspensions - based drug formulations - a solution for poorly soluble & bioavailable drugs, Int. Symp. Control. Rel. Bioact. Mater. 24, 863-864, 1997

 

(59) Olbrich, C., Mehnert, W., Müller, R.H., Effect of surfactant and lipid composition on the in vitro degradation time of solid lipid nanoparticles (SLN), Int. Symp. Control. Rel. Bioact. Mater. 24, 921-922, 1997

 

(60) Müller, R.H., Mehnert, W., Dingler, A., Runge, S.A., zur Mühlen, A., Freitas, A., Solid lipid nanoparticles (SLN™, Lipopearls™) - present state of development, Int. Symp. Control. Rel. Bioact. Mater. 24, 923-924, 1997

 

(61) Dingler, A., Hildebrand, G.E., Kielholz, J., Pfeiffer, S., Debus, N., Müller, R.H., Gohla, S., Electron and fluorescence micrographical characterisation of lipopearls™ (SLN™), Int. Symp. Control. Rel. Bioact. Mater. 24, 925-926, 1997

 

(62) Böhm, B.H.L., Behnke, D., Müller, R.H., Production of paclitaxel nanosuspensions by high-pressure homogenisation, Int. Symp. Control. Rel. Bioact. Mater. 24, 927-928, 1997

 

(63) Harnisch, S., Schuhmann, R., Müller, R.H., Calcium-induced coalescence-effect of emulsion dilution on coalescence kinetices, Int. Symp. Control. Rel. Bioact. Mater. 24, 929-930, 1997

 

(64) Müller, R.H., Diederichs, J.E., Bucke, W.E., Controlled enhancement of drug incorporation into liposomes by ascorbic acid palmitate (AP), retinol palmitate (RP) and tocopherol acetate (TA), Int. Symp. Control. Rel. Bioact. Mater. 24, 931-932, 1997

 

(65) Hildebrand, G.E., Herbort, J., Diederichs, J.E., Müller, R.H., Fluorescence polarization studies in micelles to monitor changes in colloidal structures, Int. Symp. Control. Rel. Bioact. Mater. 24, 933-934, 1997

 

(66) Dingler, A., Lukowski, G., Pflegel, P., Müller, R.H., Gohla, S., Production and characterisation of lipopearls™ for cosmetics, Int. Symp. Control. Rel. Bioact. Mater. 24, 935-936, 1997

 

(67) Lück, M., Pistel, K.F., Kissel, T., Müller, R.H., Influence of the production method on protein adsorption of biodegradable microspheres, Int. Symp. Control. Rel. Bioact. Mater. 24, 937-938, 1997

 

(68) Müller, R.H., Peters, K., Craig, D., Investigations of nanosuspensions with low-frequency dielectric analysis, Int. Symp. Control. Rel. Bioact. Mater. 24, 991-992, 1997

 

(69) Kresse, M., Wagner, S., Philipp, K., Thode, K., Müller, R.H., Semmler, W, Synthesis and Properties of Dexrtran-coated Iron Oxides for Lymph Node Targeting, Int. Symp. Control. Rel. Bioact. Mater. 24, 93-94, 1997

 

(70) Harnisch, S.. Schuhmann, R., Thode, K., Müller, R.H., Improvements on particle sizing using a laser diffractometer equipped with the PIDS technology, 2^nd World Congress on Emulsion, Bordeaux, 2-1-197, 1997

 

(71) Dingler, A., Lukowski, G., Pflegel, P., Gohla, S., Müller, R.H., Production of solid lipid nanoparticles (SLN^TM) from cosmetic lipids and surfactants, 2^nd World Congress on Emulsion, Bordeaux, 4-2-297, 1997

 

(72) Harnisch, S., Blunk, T., Müller, R.H., Analysis of plasma protein adsorption on commercial emulsions for intravenous parenteral nutrition, 2^nd World Congress on Emulsion, Bordeaux, 4-2-199, 1997

 

(73) Dingler, A., Lukowski, G., Gohla, S., Müller, R.H., Production and characterisation of solid lipid nanoparticles as colloidal carrier system for cosmetic products, 2^nd World Congress on Emulsion, Bordeaux, 4-2-296, 1997

 

(74) Dingler, A., Hildebrand, G.E., Kielholz, J., Gohla, S., Müller, R.H., Fluorescence and electron microscopic characterisation of solid lipid nanoarticles in aqueous dispersions and ointments, 2^nd World Congress on Emulsion, Bodeaux, 4-2-297, 1997

 

(75) Müller, R.H., Gohla, S., Hildebrand, G., Runge, S.A., Dingler, A, Dispersion of solid lipid nanoparticles (SLN): Production and possible applications in food, cosmetic and pharmaceutical products, 2^nd World Congress on Emulsion, Bordeaux, 1-2-195, 1997

 

(76) Harnisch, S., Schuhmann, R., Müller, R.H., A Coulter Counter based assay for high resolution analysis of the coalescence kinetics of oil-in-water emulsions, 2^nd World Congress on Emulsion, Bordeaux, 2-3-198, 1997

 

(77) Böhm, B.H.L., Grau, M.J., Hildebrand, G.E., Thünemann, A.F., Müller, R.H., Preparation and Physical Properties of Nanosuspensions (Dissocubes™) of Poorly Soluble Drugs, Int. Symp. Control. Rel. Bioact. Mater. 25, 956-957, 1998

 

(78) Müller, R.H., Dingler, A., Hildebrand, G.E., Gohla, S., Development of Cosmetic Products (Lipopearls™) based on Solid Lipid Nanoparticles, Int. Symp. Control. Rel. Bioact. Mater. 25, 238-239, 1998

 

(79) Dingler, A., Hildebrand, G., Niehus, H., Müller, R.H., Cosmetic Anti-Aging Formulation Based on Vitamin E-Loaded Solid Lipid Nanoparticles, Int. Symp. Control. Rel. Bioact. Mater. 25, 433-434, 1998

 

(80) Hildebrand, G.E., Dingler, A., Runge, S.A., Müller, R.H., Medium Scale Production of Solid Lipid Nanoparticles (SLN), Int. Symp. Control. Rel. Bioact. Mater. 25, 968-969, 1998

 

(81) Haeckel, S., Sachse, A., Albayrak, C., Müller, R.H., Preparation and characterization of insulin-loaded PLGA-microcapsules produced by the induced phase separation method, 2^nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 507-508, 1998

 

(82) Dingler, A., Müller, R.H., Gohla, S., Incorporation of Hydrophilic Active Ingredients in Solid Lipid Nanoparticles for the Topical Application, 2^nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 625-626, 1998

 

(83) Harnisch, S., Buszello, K., Müller, B.W., Müller, R.H., Influence of the Composition of Oil in Water Emulsions on the Pattern of Adsorbed Plasma Proteins, 2^nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 773-774, 1998

 

(84) Olbrich, C., Mehnert, W., Müller, R.H., In vitro Degradation Properties of Solid Lipid Nanoparticles SLN™, 2^nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 577-578, 1998

 

(85) Olbrich, C., Mehnert, W., Müller, R.H., Development of an in vitro Degradation Assay for Solid Lipid Nanoparticles, 2^nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 627-628, 1998

 

(86) Schütt, D.H., Kaiser, Stamm, I., Kubis, A., E., Müller, R.H., New Generation of Cosmetic Products Based on Solid Lipid Nanoparticles (Lipopearls™), 2^nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 585-586, 1998

 

(87) Jenning, V., Gohla S., Müller R.H., Solid Lipid Nanoparticles (SLN): Effect of homogenization parameters on drug stability, 2^nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 619-620, 1998

 

(88) Böhm, B.H.L, Behnke, D., Müller, R.H., Paclitaxel Nanosuspensions: Production, Lyophilisation and Stability, 2^nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 621-622, 1998

 

(89) Grau, M.J., Müller, R.H., Increase of Dissolution Velocity and Solubility of Poorly Soluble Drugs by Formulation as Nanosuspension, 2^nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 623-624, 1998

 

(90) Geßner, A., Lück, M., Paulke, B.R., Müller, R.H., Analysis of Plasma Protein Adsorption on Model Particles by Two-Dimensional Electrophoresis - Methodical Aspects, 2^nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 615-616, 1998

 

(91) Seehof, K., Harnisch, S., Kresse, M, Semmler, W., Müller, R.H., Protein Adsorption Patterns on to Iron Oxide MRI Contrast Media, Results for Citrated and Heparinized Human Plasma, 2^nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 617-618, 1998

 

(92) Peters, K., Leitzke, S., Ehlers, S., Borner, K., Hahn, H., Müller, R.H., Preparation of a clofazimine nanosuspension for i.v. administration, 2^nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 609-610, 1998

 

(93) Lück, M., Schröder, W., Paulke, B.R., Müller, R.H., Binding of Complement Protein C3 to Model Drug Carriers for i.v. Application - Determination by 2-D Electrophoresis, 2^nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 607-608, 1998

 

(94) Anger, S., Mehnert, W., Caldwell, K., Müller, R.H., High resolution determination of adsorption layer mass on particles by sedimentation field-flow fractionation, 2^nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 643-644, 1998

 

(95) Kresse, M., Thode, K., Wagner, S., Müller, R.H., Semmler, W., Ex vivo investigations into the opsonization of iron-oxide-based contrast media for MRI, 2^nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 611-612, 1998

 

(96) Kresse, M., Thode, K., Müller, R.H., Multi-angle and two-time window analysis: detection of aggregates in iron-oxide dispersions, 2^nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 37-38, 1998

 

(97) Krause, W., Schlichter, N., Maier, F. K., Sachse, A., Müller, R. H., Contrast Agents Based on Dendrimers and Vesicles, DECHEMA Symposion „Polymers for Medicinal Technologies, Tutzing, 8-11 March 1999

 

(98) Maia, C., Gysler, A., Mehnert, W., Müller, R. H., Schäfer-Korting, M., Local tolerability of solid lipid nanoparticles for dermal use, Int. Symp. Control. Rel. Bioact. Mater. 26, 403-404, 1999

 

(99) Zimmermann, E., Liedtke, S., Müller, R. H., Mäder, K., H-NMR as a method to characterize colloidal carrier systems, Int. Symp. Control. Rel. Bioact. Mater. 26, 595-596, 1999

 

(100)   Schöler, N., Zimmermann, E., Hahn, H., Müller, R. H., Liesenfeld, O., Establishment of an analytical assay for solid lipid nanoparticle (SLN) cytotoxicity studies, Int. Symp. Control. Rel. Bioact. Mater. 26, 593-594, 1999

 

(101)   Zimmermann, E., Schöler, N., Katzfey, U., Müller, R. H., Hahn, H., Liesenfeld, O., Aseptic production of pyrogene-free aqueous solid lipid nanoparticles (SLN^TM) dispersions for parenteral administration, Int. Symp. Control. Rel. Bioact. Mater. 26, 597-598, 1999

 

(102)   Müller, R. H., Grau, M. J., Hildebrand, G. E., Increase of solubility of poory soluble drugs by transfer to Dissocubes^TM using high pressure homogenization, Int. Symp. Control. Rel. Bioact. Mater. 26, 112-113, 1999

 

(103)   Liedtke, S., Zimmermann, E., Müller, R. H., Mäder, K., Physical characterisation of solid lipid nanoparticles (SLN^TM), Int. Symp. Control. Rel. Bioact. Mater. 26, 599-600, 1999

 

(104)   Geßner, A., Paulke, B.-R., Müller, R. H., Plasma protein adsorption on poly(ethylene-glycol) (peg)modified polystyrene nanoparticles: influence of peg surface density, Int. Symp. Control. Rel. Bioact. Mater. 26, 601-602, 1999

 

(105)   Seehof, K., Kresse, M., Semmler, W., Müller, R. H., Protein adsorption onto iron oxide MRI contrast media, Int. Symp. Control. Rel. Bioact. Mater. 26, 1156-1157, 1999

 

(106)   Olbrich, C., Kayser, O., Kiderlen, A. F., Müller, R. H., Flow cytometry as a tool for assessing cellular binding capacities of solid lipid particles (SLN), Int. Symp. Control. Rel. Bioact. Mater. 26, 519-520, 1999

 

(107)   Anger, S., Caldwell, K., Mehnert, W., Müller, R. H., Coating of nanoparticles: analysis of adsorption using sedimentation field-flow fractionation (SdFFF), Int. Symp. Control. Rel. Bioact. Mater. 26, 603-604, 1999

 

(108)   Olbrich, C., Kayser, O., Müller, R. H., Tributyrin, a potent anti cancer agent retains its biological activity after incorporation in solid lipid nanoparticles (SLN), Int. Symp. Control. Rel. Bioact. Mater. 26, 935-936, 1999

 

(109)   Jenning, V., Hildebrand, G. E., Gysler, A., Schäfer-Korting, M., Gohla, S., Solid lipid nanoparticles (SLN^TM) for topical application: occlusive properties, Int. Symp. Control. Rel. Bioact. Mater. 26, 405-406, 1999

 

(110)   Baudisch, U. Briel, A., Rößling, G., Müller, R. H., Investigation of the glass transition temperature of polybutylcyanoacrylate polymers, 3^rd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Berlin, 423-424, 2000

 

(111)   Wissing, S., Mäder, K., Müller, R. H., Prolonged efficacy of the insect repellent lemon oil by incorporation into solid lipid nanoparticles (SLN^TM), 3^rd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Berlin, 439-440, 2000

 

(112)   Schöler, N., Krause, C., Kayser, O., Müller, R. H., Hahn, H., Liesenfeld, O., In vitro efficacy of atovaquone nanosuspensions against toxoplasma gondii, 3^rd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Berlin, 437-438, 2000

 

(113)   Zimmermann, E., Müller, R. H., Mäder, K., Release of solid lipid nanoparticles (SLN^TM) from pellets under GI-simulated conditions, 3^rd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Berlin, 465-466, 2000

 

(114)   Hitschfeld, R., Kayser, O., Spohn, F., Müller, R. H., Database for management and evaluation of environmental monitoring in pharmaceutical production, 3^rd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Berlin, 629-630, 2000

 

(115)   Schöler, N., Müller, R. H., Hahn, H., Liesenfeld, O., Influence of the lipid matrix of solid lipid nanoparticles (SLN) on cytokine production and viability of macrophages, 3^rd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Berlin, 435-436, 2000

 

(116)   Krause, K., Müller, R. H., Mäder, K., Preparation and physical stability of nanosuspensions produced by high pressure homogenisation, 3^rd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Berlin, 433-434, 2000

 

(117)   Lippacher, A., Müller, R. H., Mäder, K., Production and physical characterisation of semisolid SLN dispersions as drug carrier for topical application, 3^rd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Berlin, 427-428, 2000

 

(118)   Seehof, K., Kresse, M., Müller, R. H., Plasma protein adsorption onto model magnetite dispersions: comparison between in vitro and ex vivo results by 2D-PAGE, 3^rd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Berlin, 429-430, 2000

 

(119)   Geßner, A., Lieske, A., Paulke, B.-R., Müller, R. H., Protein measurement after plasma protein adsorption on model particles using bicinchoninic acid, 3^rd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Berlin, 431-432, 2000

 

(120)   Olbrich, C., Kayser, O., Lamprecht, A., Kneuer, C., Lehr, C. M., Müller, R. H., Interactions of fluorescent solid lipid nanoparticles (SLN) with macrophage-like cells visualized by CLSM, 3^rd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Berlin, 331-332, 2000

 

(121)   Olbrich, C., Runge, S. A., Mehnert, W., Thünemann, A. F., Müller, R. H., Entrapment efficacy and biodegradation of cyclosporine loaded solid lipid nanoparticles (SLN) for peroral administration, 3^rd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Berlin, 425-426, 2000

 

(122)   Jacobs, C., Kayser, O., Müller, R. H., Comparison of APV Micron Lab 40 vs. Microfluidizer for the formulation of bupravaquone nanosuspensions, 3^rd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Berlin, 415-416, 2000

 

(123)   Funke, A. P., Günther, C., Müller, R. H., Lipp, R., Low-frequency in-vitro-sonophoresis of methyl nicotinate and nicotine at physicological skin temperature, 3^rd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Berlin, 717-718, 2000

 

(124)   Harnisch, S., Müller, R. H., Determination of plasma protein adsorption pattern on propofol-loaded oil-in-water emulsions, 3^rd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Berlin, 575-576, 2000

 

(125)   Anger, S., Caldwell, K., Müller, R. H., Coating of nanoparticles: adsorption layer detection limit of sedimentation field-flow fractionation (SedFFF), 3^rd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Berlin, 601-602, 2000

 

(126)   Videira, M., Almeida, A. J., Müller, R. H., Incorporation of paclitaxel in SLN^â: assessment of drug-lipid interaction, 3^rd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Berlin, 453-454, 2000

 

(127)   Zimmermann, E., Müller, R. H., Mäder, K., ESR-investigations on SLN^TM structure and drug incorporation, Millenium World Congress of Pharmaceutical Sciences, San Francisco, 63-64, 2000

 

(128)   Lippacher, A., Müller, R. H., Mäder, K., Investigations on semisolid SLN^TM dispersions made from solid-liquid mixtures by means of ESR and rheometry, Int. Symp. Control. Rel. Bioact. Mater. 27, 325-326, 2000

 

(129)   Krause, K. P., Nicholson, I., Panagiotelis, I., Müller, R. H., Mäder, K., Production of charcoal microparticles as colloidal oxygen sensor by high pressure homogenisation, Int. Symp. Control. Rel. Bioact. Mater. 27, Abstr. no. 6154, 2000

 

(130)   Baudisch, U., Briel, A., Rößling, G., Müller, R. H., Colloidal polybutylcyanoacrylate particles: sythesis, characterization and stability, Int. Symp. Control. Rel. Bioact. Mater. 27, 291-292, 2000

 

(131)   Olbrich, C., Geßner, A., Kayser, O., Müller, R. H., Lipid-drug-conjugate (LDC) nanoparticles as an alternative carrier system with high drug content, Int. Symp. Control. Rel. Bioact. Mater. 27, 295-296, 2000

 

(132)   Olbrich, C., Kayser, O., Müller, R. H., Grubhofer, N., Solid lipid nanoparticles (SLN) as vaccine adjuvant – study in sheep with a mycoplasma bovis antigen and stability testing, Int. Symp. Control. Rel. Bioact. Mater. 27, 293-294, 2000

 

(133)   Wissing, S. A., Mäder, K., Müller, R. H., Solid lipid nanoparticles (SLN^TM) as a novel carrier system offering prolonged release of the perfume Allure (Chanel), Int. Symp. Control. Rel. Bioact. Mater. 27, 311-312, 2000

 

(134)   Seehof, K., Kresse, M., Müller, R. H., Analysis of protein adsorption (opsonization) on different charged superparamagnetic iron oxide (SPIO) particles, Int. Symp. Control. Rel. Bioact. Mater. 27, 467-468, 2000

 

(135)   Geßner, A., Olbrich, C., Kayser, O., Müller, R. H., Serum protein adsorption on lipid drug conjugate-nanoparticles (LDC-NP): evaluation by two-dimensional electrophoresis, Int. Symp. Control. Rel. Bioact. Mater. 27, 301-302, 2000

 

(136)   Zimmermann, E., Müller, R. H., Mäder, K., ESR-investigations on drug incorporation in SLN^TM and the influence of gastrointestinal media, Int. Symp. Control. Rel. Bioact. Mater. 27, 289-290, 2000

 

(137)   Radtke, M., Müller, R. H., Comparison of structural properties of solid lipid nanoparticles (SLN^TM) versus other lipid particles, Int. Symp. Control. Rel. Bioact. Mater. 27, 309-310, 2000

 

(138)   Anger, S., Caldwell, K., Mehnert, W., Müller, R. H., Nanoparticles: Analysis of size and size distribution with sedimentation field-flow fractionation (SedFFF), Int. Symp. Control. Rel. Bioact. Mater. 27, 1080-1081, 2000

 

(139)   Müller, R. H., Solid lipid nanoparticles (SLN) as alternative delivery system, Int. Symp. Control. Rel. Bioact. Mater. 27, 188-189, 2000

 

(140)   Olbrich, C., Kayser, O., Müller, R. H., Stability and biocompatibility optimized vaccine adjuvant (SBA) – based on solid lipid nanoparticles (SLN), Int. Symp. Control. Rel. Bioact. Mater. 28, 1063-1064, 2001

 

(141)   Olbrich, C., Kayser, O., Müller, R. H., Preparation of the hydrophilic drug diminazene diaceturate as lipid drug conjugate (LDC) nanoparticles, Int. Symp. Control. Rel. Bioact. Mater. 28, 1285-1286, 2001

 

(142)   Jacobs, C., Müller, R. H., Budesonide nanosuspensions for pulmonary administration: production and aerosolisation properties, Int. Symp. Control. Rel. Bioact. Mater. 28, 215-216, 2001

 

(143)   Schmidt, S., Wissing, S., Geßner, A., Müller, R. H., Plasma protein adsorption patterns on solid lipid nanoparticles (SLN^TM): novel sample preparation protocol prior to 2-DE, Int. Symp. Control. Rel. Bioact. Mater. 28, 478-479, 2001

 

(144)   Schmidt, S., Geßner, A., Müller, R. H., Comparison of plasma protein adsorption patterns on emulsions for parenteral nutrition dependent to their age, Int. Symp. Control. Rel. Bioact. Mater. 28, 480-481, 2001

 

(145)   Krause, K. P., Müller, R. H., Production of aqueous shellac dispersions for coating of tablets and pellets by high pressure homogenisation, Int. Symp. Control. Rel. Bioact. Mater. 28, 722-723, 2001

 

(146)   Radtke, M., Müller, R. H., Stability study of creams containing cyclosporine SLN^TM, Int. Symp. Control. Rel. Bioact. Mater. 28, 472-473, 2001

 

(147)   Radtke, M., Müller, R. H., Novel concept of topical cyclosporine delivery with supersaturated SLN^TM creams, Int. Symp. Control. Rel. Bioact. Mater. 28, 470-471, 2001

 

(148)   Wissing, S. A., Müller, R. H., Solid lipid nanoparticles (SLN) as sunscreens: advantages over conventional emulsion based systems, Int. Symp. Control. Rel. Bioact. Mater. 28, 522-523, 2001

 

(149)   Anger, S., Caldwell, K., Müller, R. H., Size characterization of magnetic fluids using flow field-flow fractionation and photon correlation spectroscopy, Int. Symp. Control. Rel. Bioact. Mater. 28, 349.350, 2001

 

(150)   Geßner, A., Lieske, A., Paulke, B.-R., Müller, R. H., Serum protein adsorption on polymer nanoparticles with different surface characteristics: influence of functional groups, Int. Symp. Control. Rel. Bioact. Mater. 28, 1356-1357, 2001

 

(151)   Geßner, A., Schröder, W., Müller, R. H., Identification of mouse serum apolipoprotein a-IV facilitated by enrichment on particulate surfaces, Int. Symp. Control. Rel. Bioact. Mater. 28, 1358-1359, 2001

 

(152)   Kneuer, C., Sameti, M., Nacken, M., Olbrich, C., Bakowsky, U., Schmidt, H., Müller, R. H., Lehr, C. M., Alternative colloidal carriers for DNA delivery: surface modified silica and cationic solid lipid nanoparticles, Int. Symp. Control. Rel. Bioact. Mater. 28, 1175-1176, 2001

 

(153)   Rudolph, C., Müller, R. H., Rosenecker, J., The effect of jet nebulisation on PEI/DNA mediated gene transfer, Int. Symp. Control. Rel. Bioact. Mater. 28, 1159-1160, 2001

 

(154)   Schalper, K., Harnisch, S., Müller, R. H., Hildebrand, G. E., A novel continuously acting microscale system for preparation of PLGA nano- and microparticles, Int. Symp. Control. Rel. Bioact. Mater. 28, 1390-1391, 2001

 

(155)   Schalper, K., Harnisch, S., Müller, R. H., Hildebrand, G. E., Preparation of solid lipid microparticles by a novel hot homogenization technique, Int. Symp. Control. Rel. Bioact. Mater. 28, 1388-1389, 2001

 

(156)   Müller, R. H., Interaction of micro- and nanoparticles with cells in vitro and in vivo, Controlled Release Systems, Second Symposium, Istanbul, 11 March 2001

 

(157)   Müller, R. H., Nanostructured lipid carries (NLC) for controlled drug delivery, NanoBioTec, Münster, 24-27 September 2001

 

(158)   Müller, R. H., Karsubke, G., Lemke, S., Nanosuspension system for oral delivery of poorly soluble drugs, 11^th Symposion on solid dosage formulation, Kyoto/Japan, November 2001

 

(159)   Radtke, M., Müller, R. H., Semisold NLC^®-dispersions as a dermal delivery system – production and characterization, 4^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology ADRITELF/APV/APGI, Florence, 1167-1168, 2002

 

(160)   Müller, R. H., Radtke, M., Wissing, S. A., Nanostructured lipid carriers (NLC) – the next generation, 4^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology ADRITELF/APV/APGI, Florence, 673-674, 2002

 

(161)   Radtke, M., Müller, R. H., Semisold NLC^®-dispersions for the topical administration of cyclosporine A, 4^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology ADRITELF/APV/APGI, Florence, 1165-1166, 2002

 

(162)   Müller, R. H., Nanopure technology for the production of drug nanocrystals and polymeric particles, 4^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology ADRITELF/APV/APGI, Florence, 769-770, 2002

 

(163)   Müller, R. H., Petri, B., PathFinder^® technology for targeting to the brain – present state, 4^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology ADRITELF/APV/APGI, Florence, 819-820, 2002

 

(164)   Buttle, I., Schmidt, S., Müller, R. H., Production of amphotericin B emulsions based on SolEmuls technology, 4^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology ADRITELF/APV/APGI, Florence, 1535-1536, 2002

 

(165)   Müller, R. H., Schmidt, S., SolEmuls technology for i. v. emulsions of poorly soluble drugs: amphotericin B, 4^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology ADRITELF/APV/APGI, Florence, 1451-1452, 2002

 

(166)   Tabatt, K., Olbrich, C., Schade, R., Müller, R. H., Tissue tolerability of the stable biocompatible adjuvant (SBA), 4^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology ADRITELF/APV/APGI, Florence, 863-864, 2002

 

(167)   Wissing, S. A., Müller, R. H., In vitro and in vivo skin permeation of sunscreens from solid lipid nanoparticles (SLN^TM), supercooled melts and emulsions, 4^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology ADRITELF/APV/APGI, Florence, 1135-1136, 2002

 

(168)   Schmidt, S., Müller, R. H., Biological long-term stability of i. v. emulsions: plasma protein adsorption on propofol-loaded emulsions, 4^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology ADRITELF/APV/APGI, Florence, 1507-1508, 2002

 

(169)   Schmidt, S., Müller, R. H., Plasma protein adsorption patterns on surfaces of amphotericin B-containing fat emulsions, 4^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology ADRITELF/APV/APGI, Florence, 1509-1510, 2002

 

(170)   Uranchimeg, A., Kayser O., Müller, R. H., Production of amphotericin B nanosuspensions as a function of stabilizer concentration, 4^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology ADRITELF/APV/APGI, Florence, 725-726, 2002

 

(171)   Mühlhäuser, I., Müller, R. H., Controlled prodruction of larger sized solid lipid nanoparticles (SLN^®), 4^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology ADRITELF/APV/APGI, Florence, 781-782, 2002

 

(172)   Wissing, S. A., Lippacher, A., Müller-Goymann, C. C., Müller, R. H., Highly concentrated solid lipid nanoparticles (SLN): production and transmission electron microscopy (TEM) investigations, 4^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology ADRITELF/APV/APGI, Florence, 811-812, 2002

 

(173)   Dong, W. Y., Müller, R. H., Chemical stability of cyclosporine nanosuspension produced at stress conditions, 4^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology ADRITELF/APV/APGI, Florence, 745-746, 2002

 

(174)   Tabatt, K., Olbrich, C., Müller, R. H., Cytotoxicity of solid lipid nanoparticles on raw 264.7 macrophages, 4^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology ADRITELF/APV/APGI, Florence, 699-700, 2002

 

(175)   Yaziksiz-Iscan, Y., Wissing, S. A., Müller, R. H., Hekimoglu, S., Different production methods for solid lipid nanoparticles (SLN^TM) containing the insect repellent deet, 4^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology ADRITELF/APV/APGI, Florence, 789-790, 2002

 

(176)   Yaziksiz-Iscan, Y., Wissing, S. A., Hekimoglu, S., Müller, R. H., Development of a novel carrier system for vitamin K using solid lipid nanoparticles (SLN^TM), 4^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology ADRITELF/APV/APGI, Florence, 787-788, 2002

 

(177)   Olbrich, C., Müller, R. H., Lipid-drug conjugate (LDC) nanoparticles for incorporation of hydrophilic drugs into lipid particles, 4^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology ADRITELF/APV/APGI, Florence, 675-676, 2002

 

(178)   Schalper, K., Harnisch, S., Müller, R. H., Hildebrand, G. E., Micromixers – effective dispersion within ultrashort residence times, 4^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology ADRITELF/APV/APGI, Florence, 1517-1518, 2002

 

(179)   Schalper, K., Harnisch, S., Müller, R. H., Hildebrand, G. E., Dimensionless groups – a tool for characterization of microparticle forming processes, 4^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology ADRITELF/APV/APGI, Florence, 1299-1300, 2002

 

(180)   Radomska, A., Müller, R. H., The chemical and physical stability of the lipid matrices of solid lipid nanoparticles, 4^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology ADRITELF/APV/APGI, Florence, 683-684, 2002

 

(181)   Krause, K., Rogaschewski, S., Niehus, H., Müller, R. H., DirectCompress: a matrix-excipient compound for direct compression of prolonged release tabletts with high polymer content, 4^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology ADRITELF/APV/APGI, Florence, 271.272, 2002

 

(182)   Müller, R. H., Saupe, A., Akkar, A., The next generation after the liposomes: NLC – nanostructured lipid carriers, J. Cos. Derm. 2003, 1;3, Cosmoderm III and 5^th International Cosmetics Symposium (IcoS), 9-11 June, Istanbul, Turkey, 2003

 

(183)   Akkar, A., Bushrab, N. F., Müller, R. H., Nanosuspensions – ultra fine dispersions of actives and pigments for cosmetics, J. Cos. Derm. 2003, 1;3, Cosmoderm III and 5^th International Cosmetics Symposium (IcoS), 9-11 June, Istanbul, Turkey, 2003

 

(184)   Akkar, A., Müller, R. H., Formulation of poorly soluble actives in O/W lotions, J. Cos. Derm. 2003, 1;3, Cosmoderm III and 5^th International Cosmetics Symposium (IcoS), 9-11 June, Istanbul, Turkey, 2003

 

(185)   Labarre, D., Chauvierre, C., Petri, B., Müller, R., Couvreur, P., Vauthier, C., Poly(alkylcyanoacrylate) nanoparticles decorated with a polysaccharidic brush : 2-interactions with blood proteins, Int. Symp. Control. Rel. Bioact. Mater. 30, #345, 2003

 

(186)   Akkar, A., Müller, R. H., Production of sub-micron sized carbamazepine emulsions with SolEmuls technology, Int. Symp. Control. Rel. Bioact. Mater. 30, #201, 2003

 

(187)   Müller, R. H., Akkar, A., Physical principles of SolEmuls process technology for i. v. emulsions of poorly soluble drugs, Int. Symp. Control. Rel. Bioact. Mater. 30, #294, 2003

 

(188)   Müller, R. H., Akkar, A., Industrial production of Nanopure drug nanocrystal dispersions, Int. Symp. Control. Rel. Bioact. Mater. 30, #293, 2003

 

(189)   Souto, E. B., Wissing, S. A., Barbosa, C. M., Müller, R. H., Preparation of topical formulation containing an antimycotic agent, Int. Symp. Control. Rel. Bioact. Mater. 30, #322, 2003

 

(190)   Souto, E. B., Wissing, S. A., Barbosa, C. M., Müller, R. H., Preparation of clotrimazole-loaded NLC and SLN, Int. Symp. Control. Rel. Bioact. Mater. 30, #321, 2003

 

(191)   Cengiz, E., Wissing, S. A., Yazan, Y., Müller, R. H., TiO₂-loaded Solid Lipid Nanoparticles (SLN): UV-blocking efficiency of topical formulations, Int. Symp. Control. Rel. Bioact. Mater. 30, #224, 2003

 

(192)   Akkar, A., Müller, R. H., Solubilisation of ketoconazole by emulsification via a solvent-free process and stabilisation of the drug loaded emulsions, International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nuremberg, 627-628, 2004

 

(193)   Fichera, M., Wissing, S., Müller, R. H., Effect of 4000 bar homogenisation pressure on particle diminution in drug suspensions, International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nuremberg, 679-680, 2004

 

(194)   Hernández-Trejo, N., Kayser, O., Müller, R. H., Steckel, H., Physical stability of buparvaquone nanosuspensions following nebulization with jet and ultrasonic nebulizers, International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nuremberg, 735-736, 2004

 

(195)   Keck, C. M., Müller, R. H., Production of cyclosporine nanosuspensions for oral delivery, International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nuremberg, 449-450, 2004

 

(196)   Lai, F., Wissing, S., Fadda, A. M., Müller, R. H., SLN for agricultural application loaded with natural pesticide, International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nuremberg, 465-466, 2004

 

(197)   Möschwitzer, J., Müller, R. H., Nanosuspensions as formulation principle for chemical stabilization of chemically labile drugs, International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nuremberg, 181-182, 2004

 

(198)   Möschwitzer, J., Müller, R. H., From the drug nanocrystal to the final mucoadhesive oral dosage form, International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nuremberg, 547-548, 2004

 

(199)   Saupe, A., Wissing, S., Müller, R. H., Nanostructured Lipid Carriers (NLC) as components of cosmetical formulations: advantages over conventional emulsion-based systems, International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nuremberg, 451-452, 2004

 

(200)   Zietze, S., Müller, R. H., Reutter, W., Nuck, R., Zimmermann-Kordmann, M., Marx, U., Koch, S., Brecht, R., Glycosylation pattern of a CHO-expressed monoclonal antibody: influence of production parameters, International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nuremberg, 329-330, 2004

 

(201)   Buttle, I., Müller, R. H., Amphotericin B incorporated in parenteral emulsions by SolEmuls^® technology, Int. Symp. Control. Rel. Bioact. Mater. 31, #679, Honolulu, Hawaii, 2004

 

(202)   Buttle, I., Müller, R. H., Amphotericin B parenteral emulsion: physical characterization and chemical stability at various temperatures, Int. Symp. Control. Rel. Bioact. Mater. 31, #558, Honolulu, Hawaii, 2004

 

(203)   Möschwitzer, J., Müller, R. H., pH-sensitive multiparticulate drug delivery system as carrier for drug nanocrystals, Int. Symp. Control. Rel. Bioact. Mater. 31, #443, Honolulu, Hawaii, 2004

 

(204)   Petri, B., Mothes, R., Paulke, B. R., Schweigert, F., Müller, R. H., Plasma protein adsorption on PEG-crafted polystyrene nanoparticles measured by 2D-PAGE and SELDI-TOF MS, Int. Symp. Control. Rel. Bioact. Mater. 31, #510, Honolulu, Hawaii, 2004

 

(205)   Souto, E. B., Wissing, S. A., Barbosa, C. M., Müller, R. H., Preparation and characterisation of ketoconazole-loaded lipid nanoparticles (SLN & NLC), Int. Symp. Control. Rel. Bioact. Mater. 31, #595, Honolulu, Hawaii, 2004

 

(206)   Souto, E. B., Wissing, S. A., Barbosa, C. M., Müller, R. H., The use of hydrogels as dermatological vehicles for aqueous NLC dispersions, Int. Symp. Control. Rel. Bioact. Mater. 31, #606, Honolulu, Hawaii, 2004

 

(207)   Troester, F., Müller, R. H., Cremophor-free aqueous paclitaxel nanosuspension – production and chemical stability, Int. Symp. Control. Rel. Bioact. Mater. 31, #521, Honolulu, Hawaii, 2004

 

(208)   Üner, M., Wissing, S., Yener, G., Müller, R. H., Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC) as carriers for ascorbyl palmitate: physical stability, Int. Symp. Control. Rel. Bioact. Mater. 31, #360, Honolulu, Hawaii, 2004

 

(209)   Teeranachaideekul, V., Souto, E. B., Junyaprasert, V. B., Müller, R. H., Establishment of release model for aqueous NLC dispersions, Int. Symp. Control. Rel. Bioact. Mater. 32, #548, Miami, 2005

 

(210)   Teeranachaideekul, V., Souto, E. B., Junyaprasert, V. B., Müller, R. H., Size analysis in gels of nanostructured lipid carriers (NLC), Int. Symp. Control. Rel. Bioact. Mater. 32, #567, Miami, 2005

 

(211)   Souto, E. B., Müller, R. H., Long-term stability of clotrimazole-loaded SLN and NLC, Int. Symp. Control. Rel. Bioact. Mater. 32, #564, Miami, 2005

 

(212)   Souto, E. B., Müller, R. H., Texture analysis of SLN and NLC based hydrogels, Int. Symp. Control. Rel. Bioact. Mater. 32, #569, Miami, 2005

 

(213)   Göppert, T. M., Souto, E. B., Müller, R. H., Comparison of plasma protein adsorption patterns on solid lipid nanoparticles (SLN) for intravenous drug targeting dependent on their age, Int. Symp. Control. Rel. Bioact. Mater. 32, #547, Miami, 2005

 

(214)   Hernández-Trejo, N., de Boer, Anne H., Hagedoorn, P., Kayser, O., Frijlink, E., Müller, R. H., Buparvaquone nanosuspension for inhalation: formulation strategies and behavior during jet nebulisation, Int. Symp. Control. Rel. Bioact. Mater. 32, #192, Miami, 2005

 

(215)   Souto, E. B., Teeranachaideekul, V., Junyaprasert, V. B., Müller, R. H., Encapsulation of nicotinamide into nanostructured lipid carriers, 15^th International Symposium on Microencapsulation, Parma, 2005

 

(216)   Hernandez-Trejo, N., Hinrichs, W. L. J., Visser, M. R., Müller, R. H., Kayser, O., Frijlink, E., Enhancement of the in vitro dissolution rate of the lipophilic drug buparvaquone by incorporation into solid dispersions, PharmSciFair, Nice, 2005

 

(217)   Müller, R. H., Hommos, A., Pardeike, J., Schmidt, C., Lipid nanoparticles (NLC) as novel carrier for cosmetic – special features & state of commercialisation, InCosmetics, Barcelona, 2006

 

(218)   Petri, B., Bootz, A., Khalansky, A., Hekmatara, T., Müller, R. H., Kreuter, J., Gelperina, S., Chemotherapy of brain tumour using doxorubicin loaded surfactant-coated Poly (Butyl Cyanoacrylate) Nanoparticles: two ards mechanism of action, 5th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology,Geneva, 27-30 March, 2006

 

(219)   Bruns, C., Müller, R. H., Prinz, D., Kutz, G., Identification of topical excipients with high performance spreadability, 5th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology,Geneva, 27-30 March, 2006

 

(220)   Muchow, M., Despatova, N., Schmitz, E. I., Müller, R. H., Nanostructured lipid carriers (NLC) containing fish oil as food supplement, 5th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology,Geneva, 27-30 March, 2006

 

(221)   Müller, R. H., Hommoss, A., Schwabe, K., Rimpler, C., Nanorepair Q 10 - First Dermal Product on the Market Based on Nanostructured Lipid Carrier (NLC) Technology, 5th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology,Geneva, 27-30 March, 2006

 

(222)   Hommoss, A. Müller, R. H., Release of Perfumes: Modulation by Type of Matrix Lipid in NLC, 5th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology,Geneva, 27-30 March, 2006

 

(223)   Teeranachaideekul, V., Souto, E. B., Junyaprasert, V. B., Müller, R. H., Physicochemical characterizations of lyophilized Coenzyme Q10-loaded NLC, 5th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology,Geneva, 27-30 March, 2006

 

(224)   Teeranachaideekul, V., Souto, E. B., Junyaprasert, V. B., Müller, R. H., Effect of drug loading on viscoelastic behaviour of NLC gels, 5th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology,Geneva, 27-30 March, 2006

 

(225)   Souto, E. B., Müller, R. H., Novel approach for mechanical chracterization of SLN- and NLC-based semi-solids, 5th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology,Geneva, 27-30 March, 2006

 

(226)   Souto, E. B., Müller, R. H., Analysis of the correlation between particle size and viscoelastic properties, 5th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology,Geneva, 27-30 March, 2006

 

(227)   Teeranachaideekul, V., Petchsirivej, S., Müller, R. H., Junyaprasert, V. B., Evaluation of ascorbyl palmitate-loaded NLC gel using atomic force microscopy, Int. Symp. Control. Rel. Bioact. Mater. 33, #337, Vienna, 2006

 

(228)   Teeranachaideekul, V.,Souto, E. B., Müller, R. H., Junyaprasert, V. B., Evaluation of physical parameter before and after incorporated Q10-loaded NLC into hydrogel, Int. Symp. Control. Rel. Bioact. Mater. 33, #338, Vienna, 2006

 

(229)   Pardeike, J., Müller, R. H., Penetration enhancement and occlusion properties of coenzyme Q10 loaded NLC, Int. Symp. Control. Rel. Bioact. Mater. 33, #371, Vienna, 2006

 

(230)   Souto, E. B., Radwan, M. A., Müller, R. H., Incorporation of submicronized amphotericin B crystals into solid lipid nanoparticles (SLN), Int. Symp. Control. Rel. Bioact. Mater. 33, #774, Vienna, 2006

 

(231)   Souto, E. B., Anselmi, C., Centini, M., Müller, R. H., Physicochemical stability of a ferulic acid derivative in solid lipid nanoparticles (SLN), Int. Symp. Control. Rel. Bioact. Mater. 33, #794, Vienna, 2006

 

(232)   Hommoss, A., Müller, R. H., Schwabe, K., Rimpler, C., Nanorepair Q10 – first dermal product on the market based on nanostructured lipid carrier (NLC) technology, Int. Pharmaceutical Technology Symposium, 57-58, Antalya/Turkey, 2006

 

(233)   Müller, R. H., Mauludin, R., Drug nanocrystals – state of the art & latests developments, nt. Pharmaceutical Technology Symposium, 18-19, Antalya/Turkey, 2006

 

(234)   Mauludin, R., Möschwitzer, J., Müller, R. H., Testosterone nanosuspensions produced by high pressure homogenization – comparison of different homogenization technologies, Int. Pharmaceutical Technology Symposium, 63-64, Antalya/Turkey, 2006

 

(235)   Hentschel, A., Gramdorf, S., Müller, R. H., Kurz, T., Nanostructured lipid carriers for food applications, nt. Pharmaceutical Technology Symposium, 121-122, Antalya/Turkey, 2006

 

(236)   Hommoss, A., Müller, R. H., Lipid nanoparticles (SLN, NLC) for delivery of actives, Eli Lilly Analytic Symposium, Hamburg, 2006

 

(237)   Müller, R. H., Mauludin, R., Drug nanosuspensions fort he delivery of poorly soluble drugs, Eli Lilly Analytic Symposium, Hamburg, 2006

 

(238)   Keck, C., M., Müller, R. H., Formulation of peppermint oil in a self-emulsifying drug delivery system (SEDDS) for oral administration, Int. Symp. Control. Rel. Bioact. Mater. 34, #2204, Long Beach, 2007

 

(239)   Mauludin, R., Müller, R. H., Physical stability of rutin nanosuspension produced by high pressure homogenization, Int. Symp. Control. Rel. Bioact. Mater. 34, #1852, Long Beach, 2007

 

(240)   Müller, R. H., Keck, C. M., Oral drug nanocrystals: state of industrial development, products and future trends, Int. Symp. Control. Rel. Bioact. Mater. 34, #2202, Long Beach, 2007

 

(241)   Hommoss, A., Al-Samman, M., Müller, R. H., Stabilization of chemically labile actives using nanostructured lipid carriers (NLC), Int. Symp. Control. Rel. Bioact. Mater. 34, #1856, Long Beach, 2007

 

(242)   Hommoss, A., Peter, M., Müller, R. H., Sun protection factor (SPF) increase using nanostructured lipid carriers (NLC), Int. Symp. Control. Rel. Bioact. Mater. 34, #1855, Long Beach, 2007

 

(243)   Mauludin, R., Möschwitzer, J., Müller, R. H., Comparison of different homogenization technologies to produce ultrafine testosterone nanocrystals, Int. Symp. Control. Rel. Bioact. Mater. 34, #1851, Long Beach, 2007

 

(244)   Pardeike, J., Müller, R. H., In vitro and in vivo occlusion properties of nanostructured lipid carriers (NLC), Int. Symp. Control. Rel. Bioact. Mater. 34, #1814, Long Beach, 2007

 

(245)   Teeranachaideekul, V., Souto, E. B., Müller, R. H., Junyaprasert, V. B., Physicochemical characterization of lyophilized ascorbyl palmitate nanosuspension, Int. Symp. Control. Rel. Bioact. Mater. 34, #1953, Long Beach, 2007

 

(246)   Teeranachaideekul, V., Souto, E. B., Müller, R. H., Junyaprasert, V. B., Development of ascorbyl palmitate nanosuspension for topical drug delivery system, Int. Symp. Control. Rel. Bioact. Mater. 34, #1956, Long Beach, 2007

 

(247)   Pardeike, J., Müller, R. H., Physical stability of nanostructured lipid carriers (NLC) in an o/w urea cream, Int. Symp. Control. Rel. Bioact. Mater. 34, #1815, Long Beach, 2007

 

(248)   Joshi, M., Pardeike, J., Nikolic, S., Müller, R. H., Nanostructured lipid carriers for dermal application: Recent advances, 7^th International Conference and Workshop on Biological Barriers and Nanomedicine, University of Saarland, 2008

 

(249)   Mauludin, R., Müller, R. H., Drug release study of rutin nanocrystal-loaded tablet, 6^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona, 7-10 April, 2008

 

(250)   Pardeike, J., Müller, R. H., Phospholipase A₂-inhibitors – evaluation of the eye tolerability of PX-13 & PX-18 nanosuspensions by het-cam test, 6^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona, 7-10 April, 2008

 

(251)   Hommoss, A. Müller, R. H., Stabilisation of retinol by nanostructured lipid carriers (NLC), 6^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona, 7-10 April, 2008

 

(252)   Müller, R. H., Keck, C. M., Gohla, S., Smartcrystals: 2^nd improved generation of drug nanocrystals, 6^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona, 7-10 April, 2008