Publication list Prof. R.H. Müller
(Total Publications: 1588)
Patents/Patent applications: 21 (not listed)
Books: 20
Refereed papers: 364
Proceedings: 405
Abstracts: 753
(1) Müller, R. H., Colloidal Carriers for Controlled Drug Delivery and Targeting - Modification, Characterization and in vivo Distribution, Wissenschaftliche Verlagsgesellschaft Stuttgart, CRC Press Boca Raton, 379 S., 1991
(2) Müller, R. H., Zetapotential und Partikelladung in der Laborpraxis –
Einführung in die Theorie, praktische Meßdurchführung,
Dateninterpretation, Wissenschaftliche Verlagsgesellschaft Stuttgart, 254
S.,1996
(3) Müller, R. H., Schuhmann, R., Teilchengrößenmessung
in der Laborpraxis, Wissenschaftliche Verlagsgesellschaft Stuttgart, 191 S.,
1996
(4) Müller, R. H., Hildebrand, G. E. (Hrsg), Pharmazeutische Technologie: Moderne Arzneiformen,
Lehrbuch für Studierende der Pharmazie - Nachschlagewerk für Apotheker in
Offizin, Krankenhaus und Forschung, Wissenschaftliche Verlagsgesellschaft
Stuttgart, 1. Aufl., 348 S., 1997
(5) Müller, R. H., Mehnert, W. (Hrsg), Particle and Surface Characterisation Methods, Wissenschaftliche
Verlagsgesellschaft Stuttgart, 280 S., 1997
(6) Müller, R. H., Hildebrand, G. E. (Hrsg), Pharmazeutische Technologie: Moderne Arzneiformen,
Lehrbuch für Studierende der Pharmazie - Nachschlagewerk für Apotheker in
Offizin, Krankenhaus und Forschung, Wissenschaftliche Verlagsgesellschaft
Stuttgart, 2. erweiterte Aufl., 471 S., 1998
(7) Diederichs, J. E., Müller, R. H. (Hrsg), Future Strategies for Drug Delivery with Particulate Systems,
Wissenschaftliche Verlagsgesellschaft Stuttgart, 194 S., 1998
(8) Müller, R. H., Hildebrand, G. E., Jachowicz, R., Kubis, A., Klawe, J. (Hrsg), Technologia nowoczesnych postaci leków, Wydawnictwo Lekarskie PZWL
Warschau, 356 S., 1998
(9) Müller, R. H., Benita, S., Böhm, B. (Hrsg), Emulsions and Nanosuspensions for the Formulation of Poorly Soluble Drugs, medpharm Scientific Publishers Stuttgart, 396 S., 1998
(10) Müller, R. H., Schneppe, T.,
Qualitätsmanagement und Validierung in der pharmazeutischen Praxis, Editio Cantor Verlag Aulendorf, 182 S., 1999
(11) Zabka, M.,
Müller, R. H., Hildebrand, G. E. (Hrsg), Moderné lieky vo
farmaceutickej technológii,
slovakische Übersetzung des Lehrbuchs
„Pharmazeutische Technologie: Moderne Arzneiformen“, Slovak
Academic Press Bratislava, 487 S., 1999
(12) Kayser, O., Müller, R. H. (Hrsg),
Pharmazeutische Biotechnologie. Ein Kompendium für Forschung und Praxis,
Wissenschaftliche Verlagsgesellschaft, Stuttgart, 2000
(13) Zabka, M.,
Müller, R. H., Hildebrand, G. E. (Hrsg), Moderní lékové formy
ve farmaceutické technologii, tschechische Übersetzung des Lehrbuchs
„Pharmazeutische Technologie: Moderne Arzneiformen“, Slovak
Academic Press Bratislava, 486 S., 2001
(14) Müller, R. H., Böhm, B. (Hrsg), Dispersion
Techniques for Laboratory
and Industrial Scale Processing, Wissenschaftliche
Verlagsgesellschaft Stuttgart, 113 S., 2001
(15) Müller, R. H., Schneppe, T.,
Qualitätsmanagement und Validierung in der pharmazeutischen Praxis, Editio Cantor Verlag Aulendorf, 2. erweiterte Aufl., 218
S., 2003
(16) Kayser, O., Müller, R. H. (Hrsg), Biotechnologia Farmaceutiyczna,
polnische Übersetzung des Buches „Pharmazeutische Biotechnologie. Ein
Kompendium für Forschung und Praxis“, Wydawnictwo Lekarskie PZWL Warschau, 415 S., 2003
(17) Kayser, O., Müller, R. H. (Hrsg), Pharmaceutical Biotechnology. Drug Discovery and Clinical Applications, Wiley-VCH, Weinheim, 311 S., 2004
(18) Müller, R. H., Hildebrand, G. E. (Hrsg),
chinesische Übersetzung des Lehrbuches: Pharmazeutische Technologie: Moderne
Arzneiformen, Lehrbuch für Studierende der Pharmazie - Nachschlagewerk für
Apotheker in Offizin, Krankenhaus und Forschung, 2. erweiterte Aufl., People’s Military Medical Press, 341 S., 2004
(19) Keck, C.M., Müller, R. H., Moderne
Pharmazeutische Technologie (Modern Pharmaceutics),
Lehrbuch für Studierende der Pharmazie & Nachschlagewerk für Apotheker in
Offizin und Forschung, www.pharmazie-lehrbuch.de,
2009
(20) Keck, C.M., Müller, R. H., Moderne
Pharmazeutische Technologie (Modern Pharmaceutics),
Lehrbuch für Studierende der Pharmazie & Nachschlagewerk für Apotheker in
Offizin und Forschung, www.pharmazie-lehrbuch.de,
2. Aufl., 2012
Book chapters:
(1)
Müller, R. H., Polydispersität, elektrophoretische Beweglichkeit hochdisperser Systeme,
PhD thesis, University of
Kiel, Germany, 1983
(2)
Davis, S. S., Douglas, S., Illum, L., Jones. P. D. E.,
Mak, E., Müller, R. H., "Targeting of Colloidal Carriers and the Role of
Surface Properties", in: Targeting of Drugs with Synthetic Systems (Gregoriadis, G., Senior, J. und Poste, G., eds.) Plenum,
123, 1986
(3)
Müller, R. H., Davis, S. S., Illum, L., Mak, E., "Particle Charge and Surface Hydrophobicity of Colloidal Drug
Carriers", in: Targeting of Drugs with Synthetic Systems (Gregoriadis, G., Senior, J. und Poste, G., eds.) Plenum,
239 ,1986
(4)
Müller,
R. H., Heinemann, S., Surface Modelling of Microparticles
as Parenteral Systems with High Tissue Affinity, in: Bioadhesion
- Possibilities and Future Trends (Gurny, R. and Junginger, H. E., eds.), Wissenschaftliche
Verlagsgesellschaft Stuttgart, 202-214, 1989
(5)
Müller, R. H., Davis, S. S., Mak,
E., "Surface
Characterization of Colloidal Drug Carriers for Drug Targeting by Aqueous Two
Phase Partitioning", in: Separation using Aqueous Phase Systems:
Applications in Cell Biology and Biotechnology (Fisher, D. und Sutherland, I. A.,eds.) Plenum New York, 149-155, 1989
(6) Müller, R. H.,
Heinemann, S., Blunk, T., Rudt,
S., "PCS and
zeta potential characterization of model drug carriers - essential information
for the interpretation of in vitro and in vivo data", in: Laser Light
Scattering in Biochemistry (Sattelle, D. B. and
Harding, S., eds.), Redwood Press Ltd., Melksham, Wiltshire, 425-440, 1992
(7)
Müller, R. H., Feste Lipidnanopartikel (SLN), in: Pharmazeutische Technologie: Moderne
Arzneiformen (Müller, R. H., Hildebrand, G. E. Hrsg.), Wissenschaftliche
Verlagsgesellschaft Stuttgart, 265-272, 1997
(8)
Müller, R. H., „Nanosuspensionen - eine neue Formulierung für schwerlösliche
Arzneistoffe“, in: Pharmazeutische Technologie: Moderne Arzneiformen (Müller,
R. H., Hildebrand, G. E., Hrsg.), Wissenschaftliche Verlagsgesellschaft
Stuttgart, 273-278, 1997
(9)
Müller, R. H., „Surface Hydrophobicity - Determination by ROSE Bengal (RB) Adsorption Methods“, in: Particle and Surface Characterisation
Methods (Müller, R. H., Mehnert, W., Hrsg),
Wissenschaftliche Verlagsgesellschaft Stuttgart, 215-228, 1997
(10)Thode, K., Müller, R. H., „Theory and Set Up of Hydrophobic Interaction Cromatography
(HIC)“, in: Particle and Surface Characterisation
Methods (Müller, R. H., Mehnert, W., Hrsg),
Wissenschaftliche Verlagsgesellschaft Stuttgart, 229-234, 1997
(11)Müller, R. H., „HIC for the
Determination of Surface Hydrophobicity
of Particulates“, in: Particle and Surface Characterisation
Methods (Müller, R. H., Mehnert, W., Hrsg),
Wissenschaftliche Verlagsgesellschaft Stuttgart, 235-249, 1997
(12)Thode, K., Kresse, M., Müller, R. H., „HIC of Iron Oxide Dispersions Stabilized by Different Macromolecules“, in:
Particle and Surface Characterisation
Methods (Müller, R. H., Mehnert, W., Hrsg),
Wissenschaftliche Verlagsgesellschaft Stuttgart, 251-259, 1997
(13)Müller, R. H., Lück, M., Harnisch, S., Thode, K., „Intravenously Injected Particles; Surface Properties and Interaction
with Blood Proteins - the Key Determining the Organ Distribution“, in:
Scientific and Clinical Applications of Magnetic Carriers (Schütt,
W., Teller, J., Häfeli, U., Zborowski,
M., eds.), 135-148, 1997
(14)Müller, R. H., Solid Lipid Nanoparticles, nanosuspensions and
liposomes for pharmaceutical and cosmetic applications, in: Future Strategies
for Drug Delivery with Particulate Systems (Diederichs,
J.E. and Müller, R.H., eds.), CRC Press Boca Raton, 71-72, 1998
(15)Müller, R. H., Particulate systems for the controlled delivery of
active compounds in pharmaceutics and cosmetics, in: Future Strategies for Drug
Delivery with Particulate Systems (Diederichs, J.E.
and Müller, R.H., eds.), CRC Press Boca Raton, 73-90, 1998
(16)Runge, S. A.,
Müller, R. H., Solid lipid
nanoparticles (SLN™) for oral administration - drug incorporation and
degradation, in: Future Strategies for Drug Delivery with Particulate Systems (Diederichs, J.E. and Müller, R.H., eds.), CRC Press Boca
Raton, 91-100, 1998
(17)Peters, K.,
Müller, R. H.,
Nanosuspensions - a novel formulation of poorly soluble drugs, in: Future
Strategies for Drug Delivery with Particulate Systems (Diederichs,
J.E. and Müller, R.H., eds.), CRC Press Boca Raton, 101-108, 1998
(18)Lück, M., Paulke,
B.-P., Schröder, W., Müller, R. H.,Two-dimensional electrophoresis (2-DE) for the
determination of plasma proteins adsorbed on model drug carriers, in: Future
Strategies for Drug Delivery with Particulate Systems (Diederichs,
J. E. and Müller, R. H., eds.), CRC Press Boca Raton, 109-117, 1998
(19)Herbort, J., Diederichs,
J. E., Müller, R. H., Development
of a liposomal formulation for hair care use, in: Future Strategies for Drug
Delivery with Particulate Systems (Diederichs, J. E.
and Müller, R. H., eds.), CRC Press Boca Raton, 118-126, 1998
(20)Müller, R H.,
Runge, S. A. „Solid Lipid
Nanoparticles (SLNÒ) for controlled drug delivery“, in: Submicron
Emulsions in Drug Targeting and Delivery (Benita, S., ed.), 219-234, 1998
(21)Müller, R. H., Böhm, B. H. L., Nanosuspensions, in: Emulsions and Nanosuspensions
for the Formulation of Poorly Soluble Drugs (Müller, R. H., Benita, S., Böhm, B. H. L., eds.), medpharm
Scientific Publishers Stuttgart, 149-174, 1998
(22)Müller, R. H., Feste Lipidnanopartikel (SLN), in: Pharmazeutische
Technologie: Moderne Arzneiformen (Müller, R. H., Hildebrand, G. E. Hrsg.), 2. Auflage, Wissenschaftliche
Verlagsgesellschaft Stuttgart, 357-366, 1998
(23)Müller, R. H., Alkoholische Pflanzenextrakte, in: Pharmazeutische
Technologie: Moderne Arzneiformen (Müller, R. H., Hildebrand, G. E. Hrsg.), 2. Auflage, Wissenschaftliche
Verlagsgesellschaft Stuttgart, 119-120, 1998
(24)Müller, R. H., „Nanosuspensionen - eine neue Formulierung für
schwerlösliche Arzneistoffe“, in: Pharmazeutische Technologie: Moderne
Arzneiformen (Müller, R. H., Hildebrand, G. E., Hrsg.), 2. Auflage, Wissenschaftliche
Verlagsgesellschaft Stuttgart, 393-400, 1998
(25)Müller,
R. H., Nanorozproszenia jako nowe postacie
leku dla trudno rozpuszczalnych substancji leczniczych, in: Kubis, A., Jachowicz,
R., Müller, R. H., Hildebrand, G. E., Technologia
nowoczesnych postaci leków, Wydawnictwo Lekarskie PZWL, Warschau,
300-306, 1998
(26)Gref, R., Quellec,
P., Alonso, M. J., Tobio, M., Lück,
M., Müller, R. H., Dellacherie, E.,
PEG-Coated Nanospheres: Surface Optimization and Therapeutic Applications, in:
Targeting of Drugs: Strategies for Stealth Therapeutic Systems, (Gregoriadis, G., ed.), Kluwer Academic Pub, 275-286, 1998
(30)Müller, R. H.,
Jacobs, C., Kayser, O., Nanosuspensions for the Formulation of Poorly Soluble
Drugs, in: Pharmaceutical Emulsions and Suspensions (Nielloud,
F. and Marti-Mestres, G., eds.), Marcel Dekker,
383-407, 2000
(31)Müller, R. H.,
Olbrich, C., Neue Adjuvantien
in der Impfstofftechnologie, in: Pharmazeutische Biotechnologie (Kayser, O.,
Müller, R. H., eds.), Wissenschaftliche
Verlagsgesellschaft, 283-302, 2000
(32)Müller, R. H., Böhm, B. H. L., Grau, M. J., Nanosuspensions - a formulation approach for poorly
soluble and poorly bioavailable drugs, in: Handbook of Pharmaceutical
Controlled Release Technology (Wise, D., ed.), 345-357, 2000
(33)Müller, R. H., Dingler, A., Schneppe, T., Gohla, S., Large scale production of solid lipid nanoparticles (SLNTM)
and nanosuspensions (DissoCubesTM), in:
Handbook of Pharmaceutical Controlled Release Technology (Wise, D., ed.),
359-376, 2000
(34)Müller, R. H., Lippacher, A., Gohla, S., Solid Lipid Nanoparticles (SLNâ) as Carrier System for the Controlled Release of
Drugs, in: Handbook of Pharmaceutical Controlled Release Technology (Wise, D.,
ed.), 377-391, 2000
(35)Müller, R. H., Wissing, S. A., Solid lipid nanoparticles (SLN®, Lipopearls®) for controlled delivery of active
compounds, STP Pharma Sciences, Minutes Book
(36)Müller, R. H., Karsubke, G., Lemke, A., Nanosuspension system for oral delivery of poorly
soluble drugs, 11th Conference book of DMV Symposion
on solid dosage formulation, DMV Japan, 26-25, 2002
(37)Müller, R. H.,
Radtke, M., Wissing, S., Solid lipid nanoparticles (SLN) and nanostructured
lipid carriers (NLC) in cosmetic and dermatological preparations, in: Human
Skin, the Medium of Touch, Bulletin Technique Gattefossé
2002, 131-152, 2002
(38)Müller, R. H., Wissing, S. A., SLN and Lipopearls for
topical delivery of active compounds and contolled
release, in: Modified-Release Drug Delivery Systems (Rathbone, M. J., Hadgraft, J., Roberts, M. S., eds.), Marcel Dekker,
571-587, 2003
(39)Müller, R. H.,
Jacobs, C., Kayser, O., DissoCubes – a novel formulation for poorly soluble and poorly
bioavailable drugs, in: Modified-Release Drug Delivery Systems (Rathbone, M.
J., Hadgraft, J., Roberts, M. S., eds.), Marcel
Dekker, 135-149, 2003
(40)Müller, R. H., Lipid-Nanopartikel (SLN, NLC) zur Verkapselung von
kosmetischen Wirkstoffen, in: Kosmetikjahrbuch 2003, Global Ingredient
& Formulation Guide, Verlag für chemische
Industrie, Augsburg, 481-484, 2003
(41)Müller, R. H., Akkar, A., Drug nanocrystals of poorly soluble drugs, in: Encyclopedia
of Nanoscience and Nanotechnology (H. S. Nalwa, ed.),
American Scientific Publishers, 627-638, 2004
(42)Müller, R. H.,
Radtke, M., Wissing, S. A., Solid Lipid Nanoparticles and Nanostructured Lipid
Carriers, in: Encyclopedia of Nanoscience and
Nanotechnology (H. S. Nalwa, ed.), American
Scientific Publishers, 43-56, 2004
(43)Wissing, S., Müller, R. H., Cosmetic applications of solid lipid nanoparticles
(SLN) and nanostructured lipid carriers (NLC), in: Textbook of Cosmetic
Dermatology, 3rd Edition (Baran, R., Mailbach, H. I.,
eds.), Taylor & Francis, 71-76, 2004
(44)Kayser, O., Müller, R. H., A primer on Pharmaceutical Biotechnology and
industrial applications, in: Pharmaceutical Biotechnology (O. Kayser, R. H. Müller, eds.), Wiley-VCH, 3-8, 2004
(45)Olbrich, C., Tabatt,
K., Wissing, S. A., Schöler,
N., Müller, R. H., Solid Lipid
Nanoparticles: Interaction with cells, cytokine production and enzymatic
degradation, in: Lipospheres in Drug Targets and Delivery: Approaches, Methods
and Applications (C. Nastruzzi, ed.), Routledge,
101-125, 2004
(46)Müller, R. H., Mehnert, W., Souto, E. B., Solid lipid nanoparticles (SLN) and nanostructured
lipid carriers (NLC) for dermal delivery, in: Percutaneous Absorption: Drugs,
Cosmetics, Mechanisms, Methods, 4th Edition (R. L. Bronaugh, H. I. Maibach, eds.),
Marcel Dekker, 719-738, 2005
(47)Müller, R. H., Möschwitzer, J., Bushrab, F. N., Manufacturing of nanoparticles by milling and
homogenisation techniques, in: Nanoparticle Technology for Drug Delivery
(Gupta, Kompella, eds.), Marcel Dekker, 21-51, 2006
(48)Müller, R. H., Junghanns,
J.-U., Drug nanocrystals/nanosuspensions for the delivery of
poorly soluble drugs, in: Nanoparticulates as Drug
Carriers (V. P. Torchilin, ed.), Imperial College
Press, 307-328, 2006
(49)Müller, R. H., Souto, E. B.,
Göppert, T., Gohla, S.,
Production of biofunctionalized solid lipid nanoparticles (SLN) for
site-specific drug delivery, in: Nanotechnologies for the Life Science:
Biological and Pharmaceutical Materials (C. Kumar, ed.), Wiley-VCH,
287-303, 2006
(50)Müller, R. H., Göppert, T.
M., Protein adsorption patterns on parenteral lipid
formulations – key factor determining the in vivo fate, in: Role of Lipid
Excipients in Modifying Oral and Parenteral Drug Delivery: Basic Principles and
Biological Examples (Kishor M. Wasan, ed.),
Wiley-VCH, 124-159, 2006
(51)Souto, E. B., Müller, R. H., Lipid nanoparticles (SLN and NLC) for drug delivery,
in: Nanoparticles for pharmaceutical applications (A. Domb,
Y Tobata, R. Kumar, S. Farber, eds.), American Scientific Publishers, 103-122,
2007
(52)Möschwitzer, J., Müller, R. H., Drug
nanocrystals – the universal formulation approach for poorly soluble drugs, in:
Nanoparticulate Drug Delivery Systems: Recent Trends and Emerging Technologies
(D. Thassu, M. Deleers, Y.
Pathak, eds.), Informa Healthcare, 2007
(53)Souto, E. B., Müller, R. H., Lipid
nanoparticles (solid lipid nanoparticles and nanostructured lipid carriers) for
cosmetic, dermal and transdermal applications, in: Nanoparticulate Drug
Delivery Systems: Recent Trends and Emerging Technologies (D. Thassu, M. Deleers, Y. Pathak,
eds.), CRC Press, 213-233, 2007
(54)Müller, R. H., Keck, C. M.,
Improvement of delivery & solubility of poorly soluble drugs by nanonisation, in: Konferenzdokumentation
LTS Academy, 12-17, 4.-5. Oktober 2007
(55)Keck, C. M., Hommoss, A.,
Müller, R. H., Lipid nanoparticles (SLN, NLC, LDC) for the
enhancement of oral absorption, in: Modified Release Drug Delivery Technology
Vol. 1 (2nd edition) (R. B. Walker, J. Hadgraft,
M. S. Roberts, M. E. Lane, eds.), Informa Healthcare, 269-286, 2008
(56)Souto, E. B., Petersen, R., Müller, R. H., Lipid
nanoparticles with solid matrix for dermal delivery: solid lipid nanoparticles
and nanostructured lipid carriers, in: Modified Release Drug Delivery
Technology Vol. 1 (2nd edition) (M. J. Rathbone, J. Hadgraft, M. S. Roberts, eds.), Informa Healthcare,
357-379, 2008
(57)Souto, E. B., Müller, R. H., Challenging
cosmetics: Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers NLC),
in: Science and Applications of Skin Delivery Systems (J. Wiechers,
A. Kozlowski, eds.), Allured Publishing, 227-250, 2008
(58)Souto, E. B., Müller, R. H., Solid lipid
nanoparticles (SLN) and nanostructured lipid carriers (NLC) – lipid
nanoparticles for medicals and pharmaceuticals, in: Encyclopedia
of Nanoscience and Nanotechnology, 2nd Edition (H. S. Nalwa, ed.), American Scientific Publishers, 2009
(59)Souto, E. B., Teeranchaideekul,
V., Boonme, P., Müller, R. H., Junyaprasert,
V. B., Lipid-based nanocarriers for cutaneous administration
of pharmaceutics, in: Encyclopedia of Nanoscience and
Nanotechnology, 2nd Edition (H. S. Nalwa,
ed.), American Scientific Publishers, 2009
(60)Keck, C.M., Müller, R. H, Photonenkorrelationsspektroskopie, in: Moderne Pharmazeutische
Technologie (C.M. Keck, R.H. Müller, eds.), 56-61,
2009
(61)Pardeike, J., Müller, R. H., Bestimmung der
Hautfeuchtigkeit, Hautelastizität und des transepidermalen Wasserverlustes
(TEWL), in: Moderne
Pharmazeutische Technologie (C.M. Keck, R.H. Müller, eds.),
84-87, 2009
(62)Pardeike, J., Müller, R. H., HET-CAM Test, in: Moderne Pharmazeutische Technologie (C.M.
Keck, R.H. Müller, eds.), 91-93, 2009
(63)Pardeike, J., Müller, R. H., Tape Stripping
Test, in: Moderne Pharmazeutische Technologie (C.M.
Keck, R.H. Müller, eds.), 110-112, 2009
(64)Keck, C. M., Al Shaal, L.,
Müller, R. H., smartCrystals – review of
the second generation of drug nanocrystals, in: Handbook of Materials for
Nanomedicine (V. Torchillin,
M. M. Amiji, eds.), Pan Stanford Series on Biomedical
Nanotechnology, Pan Stanford Publishing, London, 555-580, 2010
(65)Souto, E. B., Müller, R. H., Lipid
nanoparticles – effect on bioavailability and pharmacokinetic changes, in:
Handbook of Experimental Pharmacology, Handbook of Experimental Pharmacology
Vol 197: Drug Delivery, Springer Publishing House, 115-141, 2010
(66)Souto, E. B., Keck, C., Müller, R. H.,
Technology of lipid nanoparticles (SLN, NLC) as nanocarriers for skin
applications: properties, production & cosmetic formulations, in:
Cosmetics: Types, Allergies and Applications (L. M. Hayes, ed.), Nova
Scientific Publishers, Hauppauge, New York, USA, Chapter 3, 69-91, 2011
(67)Souto, E. B., Teeranachaideekul,
V., Boonme, P., Müller, R. H.,
Lipid-based nanocarriers for cutaneous administration of pharmaceutics, in: Encyclopedia of Nanoscience and Nanotechnology Vol. 15 (H.
S. Nalwa, ed.), American Scientific Publishers,
Valencia/USA, 479-491, 2011
(68)Souto, E. B., Müller, R. H., Solid lipid
nanoparticles and nanostructured lipid carriers – lipid nanoparticles for
medicals and pharmaceuticals, in: Encyclopedia of
Nanoscience and Nanotechnology Vol. 23 (H. S. Nalwa,
ed.), American Scientific Publishers, Valencia/USA, 313-328, 2011
(69)Müller
R.H., Shegokar R., Gohla,
S., Keck, C.M., NanoCrystals: Production, cellular drug delivery and
current and future products, in: Intracellular Delivery, Fundamental Biomedical
Technologies, Vol.5 (Part 2) (A. Prokop, ed.), Springer Science+Business
Media, 411-432 (doi:10.1007/978-94-007-1248-5_15), 2011
(70)Möschwitzer, J., Müller, R. H., Nanocrystal
formulations for improved delivery of poorly soluble drugs, in: Nanomedicines
in Health and Disease (R. J. Hunter, V. R. Preedy,
eds.) CRC Press, New York, USA, 79-99, 2011
(71)Keck, C. M., Kobierski, S., Mauludin, R., Müller, R. H., Novel top down
technologies: Effective production of ultra-fine drug nanocrystals, in: Drug
Delivery Strategies for Poorly Water-Soluble Drugs (D. Douroumis,
A. Fahr, eds.) Wiley, 247-264, 2013
(72)Keck, C. M., Müller, R. H., Schäfer, K. H., Nanotaxis for antioxidants to make them biologically
active, in: Recent advances in redox active plant and microbial products: From
basic chemistry to widespread applications in Medicine and Agriculture, (C.
Jacob, ed.), Springer, 401-424, 2014
(73)Müller, R. H., Alexiev, U., Sinambela, P., Keck,
C. M., Nanostructured
lipid carriers (NLC): the second generation of solid lipid nanoparticles, in:
Percutaneous Penetration Enhancers. Chemical Methods in Penetration
Enhancement, (N. Dragicevic, H. I. Maibach, eds.), Springer,161-185, 2016
(74)Müller, R. H., Zhai, X., Romero, G. B., Keck, C. M., Nanocrystals for Passive Dermal
Penetration Enhancement, in: Percutaneous Penetration Enhancers. Chemical
Methods in Penetration Enhancement, (N. Dragicevic,
H. I. Maibach, eds.), Springer, 283-295, 2016
(75)Müller, R. H. and Möschwitzer,
J., Nanosuspensions for the Formulation of Poorly Soluble
Drugs, in: Pharmaceutical Emulsions and Suspensions (F. Nielloud,
G. Marti-Mestres, eds.), 2nd edition,
Publisher: Marcel Dekker, submitted
(76)Pyo,
S. M., Müller, R. H., Keck, C. M.,
Encapsulation by nanostructured lipid carriers, in: Nanoencapsulation
Technologies for the Food and Neutraceutical
Industries (Jafar, S. M., ed.), Academic Press,
114-137, 2017
(77)Romero, G. B., Brysch, W., Keck, C. M., Müller, R. H., Nanocapsule
formation by nanocrystals, in: Nanoencapsulation Technologies for the Food and Neutraceutical Industries (Jafar,
S. M., ed.), Academic Press, 165-186, 2017
(1) Müller, B. W. und Müller, R. H., Particle Size Analysis of Latex Suspensions and Microemulsions by Photon Correlation Spectroscopy, J. Pharm. Sci. 73 (7), 915-918, 1984
(2) Müller, B. W. und Müller, R. H., Particle Size Distributions and Particle
Size Alterations in Microemulsions, J. Pharm. Sci. 73 (7),
919-922, 1984
(3) Müller, B. W., Merz, J. und Müller, R.
H., Simultane Bestimmung von elektrophoretischer Beweglichkeit und
Teilchengröße bei überlagerter Konvektion an Suspensionen und Emulsionen, Colloid & Polymer Sci. 263,
342-347, 1985
(4) Illum, L., Davis, S. S., Müller, R. H., Mak, E. und West, P., The organ distribution and circulation time of intravenously injected colloidal carriers sterically stabilized with a blockcopolymer - poloxamine 908, Life Sciences 40, 367-374, 1987
(5) Illum, L., Jacobsen, L. O., Müller, R. H., Mak, E. und Davis, S. S., Surface Characteristics and the Interaction of Colloidal Particles with Mouse Peritoneal Macrophages, Biomaterials 8, 113-117, 1987
(6) Koosha, F., Müller, R. H., Davis, S. S., Polyhydroxybutyrate as a Drug Carrier, Critical Reviews in Therapeutic Drug Carrier Systems 6, (2), 117-130, 1989
(7) Koosha, F., Müller, R. H., Davis, S. S. und Davies, M. C., The Surface Chemical Structure of Poly (ß-hydroxybutyrate) Microparticles Produced by Solvent Evaporation Process, J. Contr. Rel. 9, 149-157, 1989
(8) Davis, S. S., Illum, L., Müller, R. H., Landry, F., Wright, J., Harper, G., The Effect of Infused Fat Emulsions on Reticuloendothelial Function in the Rabbit, Clinical Nutrition 9, 260-265, 1990
(9) Lucks, J. S., Müller, B. W., Müller, R. H., Inorganic Suspensions - Interaction with Salts and Ionic Surfactants, Int. J. Pharm. 58, 229-235, 1990
(10) Müller, R. H., Lherm, C., Herbort, J., Couvreur, P., In Vitro Model for the Degradation of Alkylcyanoacrylate Nanoparticles, Biomaterials 11, 590-595, 1990
(11) Lucks,
J. S., Müller, B. W., Müller, R. H., Polymeric and emulsion
carriers - Interaction with antiflocculants and ionic
surfactants, Int. J. Pharm. 63, 183-188, 1990
(12) Wallis, K. H., Müller, R. H., Stabilität von Poloxamer und Poloxamine Coatingfilmen auf Polystyrol Nanopartikeln, Acta Pharm. Technol. 36 (3), 127-132, 1990
(13) Carstensen, H., Müller, B. W., Müller, R. H., Adsorption of ethoxylated surfactants on nanoparticles. I. Characterization by Hydrophobic Interaction Chromatography, Int. J. Pharm. 67, 29-37, 1991
(14) Müller, R. H., Lherm, C., Herbort, J., Couvreur, P., Propidium Iodide Loaded Polyalkylcyanoacrylate Particles - Labelling Conditions and Loading Capacity, Colloid & Polym. Sci. 269, 147-152, 1991
(15) Stampa, B., Lucks, J. S., Müller, B. W., Müller, R. H., Electrophoretic properties of emulsions for parenteral nutrition determined by laser light scattering and application of the amplitude weighted phase structure function (AWPS), J. Coll. Interf. Sci. 143 (1), 188-194, 1991
(16) Lukowski, G., Müller, R. H., Müller, B. W., Dittgen, M., Acrylic acid copolymer nanoparticles for drug delivery. I: Characterization of the surface properties relevant for in vivo organ distribution, Int. J. Pharm. 84, 23-31, 1992
(17) Müller, R. H., Heinemann, S., Fat emulsions for parenteral nutrition I: Evaluation of microscopic and laser light scattering methods for the determination of the physical stability, Clinical Nutrition 11, 223-236, 1992
(18) Tröster, S. D., Wallis, K. H., Müller, R. H., Kreuter, J., Correlation of the surface hydrophobicity of 14C-poly (methyl methacrylate) nanoparticles to their body distribution, J. Control. Rel. 20, 247-260, 1992
(19) Müller, R. H., Wallis, K. H., Tröster, S. D., Kreuter, J., In vitro characterization of poly (methyl methacrylate) nanoparticles and correlation to their in vivo fate, J. Control. Rel. 20, 237-246, 1992
(20) Müller, R. H., Lherm, C., Herbort, J., Blunk, T., Couvreur, P., Alkylcyanoacrylate Drug Carriers I: Physicochemical Characterization of Nanoparticles with Different Alkyl Chain Length, Int. J. Pharm. 84, 1-11, 1992
(21) Lherm, C., Müller, R. H., Puisieux F., Couvreur, P., Alkylcyanoacrylate Drug Carriers II: Cytotoxicity of Cyanoacrylate Nanoparticles with Different Alkyl Chain Length, Int. J. Pharm. 84, 13-22, 1992
(22) Carstensen, H., Müller, R. H., Müller, B. W., Particle size, surface hydrophobicity and interaction with serum of parenteral fat emulsions and model drug carriers as parameters related to RES uptake, Clinical Nutrition 11, 289-297, 1992
(23) Rudt, S., Müller, R. H., In vitro phagocytosis assay of nano- and microparticles by chemiluminescence. I. Effect of analytical parameters, particle size and particle concentration, J. Control. Rel. 22, 263-272, 1992
(24) Lukowski, G., Müller, R. H., Müller, B. W., Dittgen, M., Acrylic acid copolymer nanoparticles for drug delivery. II: Characterization of nanoparticles surface-modified by adsorption of ethoxylated surfactants, Colloid & Polym. Sci. 271, 100-105, 1993
(25) Müller, R. H., Wallis, K. H., Surface modification of i.v. injectable biodegradable nanoparticles with poloxamer polymers and poloxamine 908, Int. J. Pharm. 89, 25-31, 1993
(26) Wesemeyer, H., Müller, B. W., Müller, R. H., Adsorption of ethoxylated surfactants on nanoparticles. II. Determination of adsorption enthalpy by microcalorimetry, Int. J. Pharm. 89, 33-40, 1993
(27) Müller, R. H., Heinemann, S., Fat emulsions for parenteral nutrition II: Characterization and physical long-term stability of Lipofundin MCT/LCT, Clinical Nutrition 12, 298-309, 1993
(28) Maaßen, S., Fattal, E., Müller, R. H., Couvreur, P., Cell cultures for the assessment of toxicity and uptake of polymeric particulate drug carriers, S.T.P. Pharma Sciences 3 (1), 11-22, 1993
(29) Rudt, S., Müller, R. H., In vitro phagocytosis assay of nano- and microparticles by chemiluminescence. II. Effect of surface modification by coating of particles with poloxamer on the phagocytic uptake, J. Control. Rel. 25, 51-59, 1993
(30) Rudt, S., Müller, R. H., In vitro phagocytosis assay of nano- and microparticles by chemiluminescence. III. Uptake of differently sized surface-modified particles, and its correlation to particle properties and in vivo distribution, Eur. J. Pharm. Sci. 1, 31-39, 1993
(31) Rudt, S., Wesemeyer, H., Müller, R. H., In vitro phagocytosis assay of nano- and microparticles by chemiluminescence. IV. Effect of surface modification by coating of particles with poloxamine and Antarox CO on the phagocytic uptake, J. Control. Rel. 25, 123-132, 1993
(32) Rudt, S., Müller, R. H., In vitro uptake of polystyrene latex particles and parenteral fat emulsions by human granulocytes, Int. J. Pharm. 99, 1-6, 1993
(33) Blunk, T., Hochstrasser, D. F., Sanchez, J.-C., Müller, B. W., Müller, R. H., Colloidal Carriers for Intravenous Drug Targeting: Plasma Protein Adsorption Patterns on Surface-Modified Latex Particles Evaluated by Two-dimensional Polyacrylamide Gel Electrophoresis, Electrophoresis 14, 1382-1387, 1993
(34) Schwarz, C., Mehnert, W., Lucks, J. S., Müller, R. H., Solid lipid nanoparticles (SLN) for controlled drug delivery. I. Production, characterization and sterilization, J. Control. Rel. 30, 83-96, 1994
(35) Bock, T. K., Lucks, J. S., Kleinebudde P., Müller R. H., Müller B. W., High Pressure Homogenisation of Parenteral Fat Emulsions - Influence of Process Parameters on Emulsion Quality, Eur. J. Pharm. Biopharm. 40 (3), 157-160, 1994
(36) Müller, R. H., Heinemann, S., Fat emulsions for parenteral nutrition III: Lipofundin MCT/LCT regimens for total parenteral nutrition (TPN) with low electrolyte load, Int. J. Pharm. 101, 175-189, 1994
(37) Müller, R. H., Heinemann, S., Fat emulsions for parenteral nutrition IV: Lipofundin MCT/LCT regimens for total parenteral nutrition (TPN) with high electrolyte load, Int. J. Pharm. 107, 121-132, 1994
(38) Paulke, B.-R., Möglich, P.-M., Knippel, E., Budde, A., Nitzsche, R., Müller, R. H., Electrophoretic 3D-mobility profiles of latex particles with different surface groups, Langmuir 11, 70-74, 1995
(39) Gref, R., Domb, A., Quellec, P., Blunk, T., Müller, R. H., Verbavatz,
J. M., Langer, R., The controlled intravenous delivery of drugs using
PEG-coated sterically stabilized nanospheres, Adv. Drug Deliv.
Rev. 16, 215-233, 1995
(40) Müller, R. H., Mehnert, W., Lucks, J. S., Schwarz, C., zur Mühlen, A., Weyhers, H., Freitas, C., Rühl, D., Solid Lipid Nanoparticles (SLN) - An Alternative Colloidal Carrier System for Controlled Drug Delivery, Eur. J. Pharm. Biopharm. 41 (1), 62-69, 1995
(41) Blunk, T., Lück, M., Calvör, A., Hochstrasser, D. F., Sanchez, J.-C., Müller, B. W., Müller, R. H., Kinetics of Plasma Protein Adsorption on Model Particles for Controlled Drug Delivery and Drug Targeting, Eur. J. Pharm. Biopharm. 42 (4), 262-268, 1996
(42) Zingel, C., Sachse, A., Rößling, G. L., Müller, R. H., Lyophilization and Rehydration of Iopromide-Carrying Liposomes, Int. J. Pharm. 140, 13-24, 1996
(43) Hedemann, H., Lück, M., Blunk, T., Frokjaer, S., Müller, R. H., Fat emulsions based on structured lipids (1,3-specific triglycerides): An investigation of the in vitro interaction with plasma protein, Clin. Nutr. 15, 175-178, 1996
(44) Müller, R. H., Maaßen, S., Weyhers, H., Specht, F., Lucks, J. S., Cytotoxicity of magnetite loaded polylactide, polylactide/glycolide particles and solid lipid nanoparticles (SLN), Int. J. Pharm. 138, 85-94, 1996
(45) Ehlers, S., Bucke, W., Leitzke, S., Fortmann, L., Smith, D., Hänsch, H., Hahn, H., Bancroft, G., Müller, R. H., Liposomal amikacin for treatment of M. avium infections in clinically relevant experimental settings, Int. J. Med. Microbiol. Virol. Parasitol. Infect. Dis. 284, 218-231, 1996
(46) Müller, R. H., Maaßen, S., Weyhers, H., Mehnert, W., Phagocytic uptake and cytotoxicity of solid lipid nanoparticles (SLN) sterically stabilized with Poloxamine 908 and Poloxamer 407, J. Drug Targeting 4 (3), 161-170, 1996
(47) Müller, R. H., Rühl, D., Lück, M., Paulke, B.-R., Influence of fluorescent labelling of polystyrene particles on phagocytic uptake, surface hydrophobicity and plasma protein adsorption, Pharm. Res. 14 (1), 18-24, 1997
(48) Diederichs, J. E., Müller R. H., Microviscosity Measurements: Theory and Application for Parenteral Fat Emulsions, Pharm. Tech., Jan. 1997, 41-56, 1997
(49) Almeida, A. J., Runge, S., Müller, R. H., Peptide-loaded Solid Lipid Nanoparticles (SLN): Influence of production parameters, Int. J. Pharm. 149, 255-265, 1997
(50) Müller, R. H., Maaßen, S., Schwarz, C., Mehnert, W., Solid Lipid Nanoparticles (SLN) formulation for human use: interaction with human granulocytes, J. Contr. Rel. 47, 261-269, 1997
(51) Rühl. D., Schulze-Forster, K., Müller, R. H., Interaction of differentiated HL60 cells with Poloxamer and Poloxamine surface modified model drug carriers, Eur. J. Pharm. Biopharm. 5, 147-153, 1996
(52) Müller, R. H., Rühl, D., Runge, S., Biodegradation of SLN as a Function of Lipase Incubation time, Int. J. Pharm. 144, 115-121,1997
(53) Müller, R. H., Rühl, D., Runge, S., Schulze-Forster, K., Mehnert, W., Cytotoxicity of Solid Lipid Nanoparticles as a Function of the Lipid Matrix and the Surfactant, Pharm. Res. 14 (4), 458-462, 1997
(54) Thode, K., Lück,
M., Kresse, M., Semmler,
W., Müller, R. H.,
Determination of Plasma Protein Adsorption on Magnetic Iron Oxides: Sample
Preparation, Pharm. Res. 14 (7), 905-910, 1997
(55) Müller, R. H., Weyhers, H., zur
Mühlen, A., Dingler, A., Mehnert, W., Solid
Lipid Nanoparticles (SLN) - ein neuartiger
Wirkstoff-Carrier für Kosmetika und Pharmazeutika, I. Systemeigenschaften,
Herstellung und Scaling up,
Pharm. Ind. 59 (5), 423-427, 1997
(56) Mehnert, W., zur Mühlen, A., Dingler,
A., Weyhers, H., Müller, R. H., Solid
Lipid Nanoparticles (SLN) - ein neuartiger
Wirkstoff-Carrier für Kosmetika und Pharmazeutika, II. Wirkstoff-Inkorporation,
Freisetzung und Sterilisierbarkeit, Pharm. Ind. 59
(6), 511-514, 1997
(57) Müller, R. H., Dingler, A., Weyhers, H., zur Mühlen, A., Mehnert, W., Solid Lipid
Nanoparticles (SLN) - ein neuartiger Wirkstoff-Carrier
für Kosmetika und Pharmazeutika, III. Langzeitstabilität, Gefrier- und
Sprühtrocknung, Anwendung in Kosmetika und Pharmazeutika, Pharm. Ind. 59 (7), 614-619, 1997
(58) Müller, R. H. and Runge, S. A., Kontrolowane dawkowanie leku za pomoca
koloidalnych nošników
(Kontrollierte Arzneistoffapplikation mit kolloidalen Carriern), Roczniki Naukowe, 1997
(59) Lück, M., Schröder, W., Harnisch, S., Thode, K., Blunk, T., Paulke, B.-R., Kresse, M., Müller, R. H., Identification of plasma proteins facilitated by enrichment on particulate surfaces: Analysis by two-dimensional electrophoresis and N-terminal microsequencing, Electrophoresis 18, 2961-2967, 1997
(60) Lück, M., Paulke, B.-R., Schröder, W., Blunk, T., Müller, R. H., Analysis of
plasma protein adsorption on polymeric nanoparticles with different surface
characteristics, J. Biomed. Mat. Res., 478-485, 1997
(61) Bucke, W.
E., Leitzke, S., Diederichs,
J. E., Borner, K., Hahn, H., Ehlers, Müller, R. H.,
Surface-modified amikacin-liposomes: Organ distribution and interaction with
plasma proteins, J. Drug Targ. 5 (2), 99-108, 1997
(62) Thode, K., Lück, M., Schröder, W., Kresse, M., Semmler, W., Müller, R. H., Influence of the sample preparation on plasma protein adsorption onto macromolecule stabilized iron oxide particles and N-terminal microsequencing of unknown proteins, J. Drug Targ. 5 (1), 35-43, 1997
(63) Müller,
R .H., Peters, K., Nanosuspensions for the formulation of poorly soluble
drugs. I. Preparation by a size-reduction technique, Int. J. Pharm. 160,
229-237, 1998
(64) Schuhmann, R., Müller, R. H., Optimierung der Probenaufbereitung für Coulter-Counter-Messungen, Pharm. Ind. 60 (2), 157-163, 1998
(65) Harnisch, S., Müller, R .H., Plasma protein adsorption patterns on emulsions for the parenteral administration: Establishment of a protocol for two-dimensional polyacrylamide electrophoresis. Electrophoresis, 19, 349-354,1998
(66) Lück, M., Pistel, K. F., Li, Y.-X., Blunk, T., Müller, R. H., Kissel, T., Plasma protein adsorption on biodegradable microspheres consisting of poly (DL-lactide-co-glycolide), poly(L-lactide) or ABA triblock copolymers containing poly(oxyethylene): Influence of production method and polymer composition, J. Control. Rel. 55, 107-120, 1998
(67) Leitzke, S., Bucke, W., Borner, K., Müller, R. H., Hahn, H., Ehlers, S., Rationale and efficacy of prolonged-interval treatment using liposome-encapsulated Amikacin in experimental M. avium infection, Antimicrob. Agents Chemother., 459-461, 1998
(68) Freitas, C., Müller, R. H., Spray Drying of Solid Lipid Nanoparticles (SLN™), Eur. J. Pharm. Biopharm. 46, 145-151, 1998
(69) Freitas, C., Müller, R. H., Effect of light and temperature on zeta potential and physical stability in Solid Lipid Nanoparticle (SLN™) Dispersions. Int. J. Pharm. 168, 221-229, 1998
(70) Thode, K., Lück, M., Schröder, W., Blunk, T., Müller, R. H., Kresse, M., The influence of the sample preparation on plasma protein adsorption patterns on polysaccharide-stabilized iron oxide particles and N-terminal microsequencing of unknown proteins, J. Drug. Targ. 5 (6), 459-469, 1998
(71) Freitas, C., Müller, R. H., Correlation between long-term stability of solid lipid nanoparticles (SLN™) and crystallinity of the lipid phase, Eur. J. Pharm. Biopharm. 47, 125-132, 1999
(72) Freitas, C., Müller, R. H., Stability Determination of Solid Lipid Nanoparticles (SLN™) in Aqueous Dispersion after Addition of Electrolyte, Journal of Microencapsulation 16 (1), 59-71, 1999
(73) Müller, R. H., Dobrucki, R., Radomska, A., Solid lipid nanoparticles as a new formulation with retinol, Acta Poloniae Pharmaceutica 56 (2), 117-120, 1999
(74) Müller, R. H., Böhm, B. H. L., Grau, M. J., Nanosuspensions - Formulierungen für schwerlösliche
Arzneistoffe mit geringer Bioverfügbarkeit: I. Herstellung und Eigenschaften,
Pharm. Ind. 61 (1), 74-78, 1999
(75) Müller, R. H., Böhm, B. H. L., Grau, M. J.,
Nanosuspensionen - Formulierungen für schwerlösliche Arzneistoffe mit geringer
Bioverfügbarkeit: II. Stabilität, biopharmazeutische Aspekte, mögliche
Arzneiformen und Zulassungsfragen, Pharm. Ind. 61
(2), 175-178, 1999
(76) Pinto, J. F., Müller, R. H., Pellets as carriers of
solid lipid nanoparticles
(SLN™) for oral administration
of drugs, Die Pharmazie 54,
506-509, 1999
(77) Müller, R. H., Olbrich, C., Solid Lipid Nanoparticles (SLN): Phagocytic uptake, in vitro cytotoxity and in vivo biodegradation, 1st Communication, Pharm. Ind. 61, 462-467, 1999
(78) Müller, R. H., Olbrich, C., Solid Lipid Nanoparticles (SLN): Phagocytic uptake, in vitro cytotoxity and in vivo biodegradation, 2nd Communication, Pharm. Ind. 61, 564-569, 1999
(79) Olbrich, C., Müller, R. H., Enzymatic degradation of SLN - Effect of surfactant and surfactant mixtures, Int. J. Pharm. 180, 31-39, 1999
(80) Peters, K., Müller, R. H., Craig, D. Q. M., An Investigation into the Distribution of Lecithins [between Vesicles and Drug Particles] in Nanosuspension Systems using Low Frequency Dielectric Spectroscopy, Int. J. Pharm. 184, 53-61, 1999
(81) Dingler, A., Blum, R. P., Niehus, H., Gohla, S., Müller, R. H., Solid lipid nanoparticles (SLNTM/LipopearlsTM) - A pharmaceutical and cosmetic carrier for the application of vitamin E in dermal products, Journal of Microencapsulation 16 (6), 751-767, 1999
(82) Lück, M., Schröder, W., Paulke, B.-R., Blunk, T., Müller, R. H., Complement Activation by Model Drug Carries for Intravenous Application: Determination by Two-Dimensional Electrophoresis, Biomaterials 20, 2063-2068, 1999
(87) Müller, R. H., Olbrich, C., Solid Lipid Nanoparticles: Phagocytic uptake, in vitro cytotoxicity and in vitro biodegradation, Drugs 42, 65-88, 1999
(89) Harnisch, S., Müller, R.H., Adsorption kinetics of plasma proteins on oil-in-water emulsions for parenteral nutrition, Eur. J. Pharm. Biopharm. 49, 41-46, 2000
(107)Krause, W., Schlichter-Hackmann, N., Maier, F. K., Müller, R. H., Dendrimers in Diagnostics, in: Topics in Current Chemistry. Vol. 210, 261-308, 2000
(116)Müller, R. H., Jacobs, C., Kayser, O., Nanosuspensions as particulate drug formulations in therapy – Rationale for Development and what we can expect for the future, in: Advanced Drug Delivery Reviews (ADDR) 47, 3-19, 2001
Non-refereed papers:
(1) Müller, R. H., Moderne Partikelmeßmethoden und ihre Anwendung in der Pharmazie,
Teil 1: Mikroskopie und Weißlichtmessungen, Pharmazeutische Verfahrenstechnik
heute 1, (12), 87-89, 1983
(2) Müller, R. H. , Moderne Partikelmeßmethoden und ihre Anwendung in der Pharmazie
Teil 2: Meßverfahren unter Verwendung von Laserlicht,
Pharmazeutische Verfahrenstechnik heute 1, (13), 91-94, 1983
(3) Müller, B. W. ,Müller, R. H., Bestimmung von
mittleren Durchmessern und Größenverteilung an Teilchen im submikroskopischen
Bereich mit der Photonenkorrelationsspektroskopie, Pharmazeutische Industrie
45, (11), 1150-1153, 1983
(4) Müller, R. H., Merz, J., Moderne Meßmethoden zur Bestimmung der Teilchenladung, Teil 1,
Pharmazeutische Verfahrenstechnik heute 1, (20), 137-140, 1984
(5) Müller, R. H. und Merz, J., Moderne Meßmethoden zur Bestimmung der Teilchenladung, Teil 2,
Pharmazeutische Verfahrenstechnik heute 1, (21), 141-144, 1985
(6) Müller, R. H., Heinemann, S., Drug
Targeting. Kolloide Carrier zur intravenösen Applikation - Wunschtraum oder
realistische Chance?, Deutsche Apotheker Zeitung 129 (41), 2188-2193, 1989
(7) Müller,
B. W., Lucks, J. S., Stampa, B. und Müller, R. H., Effect of
Anti-flocculants on Suspension Stability and Size Distribution - An
investigation by laser light scattering techniques, Pharm. Ind. 52 (6), 789-793, 1990
(8) Müller, R. H., Heinemann, S., Smal, R., Stabilitätsbestimmung von Fettemulsionen zur
parenteralen Ernährung, Deutsche Apotheker Zeitung 130 (6), 282-284, 1990
(9) Müller, R. H., Heinemann, S., Smal, R., Bestimmung der Organverteilung von Arzneiformen und
Wirkstoffen durch Gamma-Szintigraphie, Deutsche Apotheker Zeitung 130 (8),
404-406, 1990
(10) Müller, R. H., Herbort, J., Lherm, C., Couvreur, P., Nanopartikel:
Gewebsspezifische Arzneiform für Zytostatika, Deutsche Apotheker Zeitung 130
(27), 1509-1511, 1990
(11) Müller, R. H., Herbort, J., Smal, R., Heinemann, S., Latices:
Polymerpartikel für Forschung und Arzneimittelherstellung, Deutsche Apotheker
Zeitung 130 (21), 1210-1211, 1990
(12) Bräuer, A., Müller, R. H., Zellkulturen:
Hepatozyten als In-vitro-Testsystem, Deutsche Apotheker Zeitung 130 (25),
1404-1405, 1990
(13) Müller, R. H., Herbort, J., Couvreur, P., Chiannilkulchai,
N., Optimierung von Zytostatika-Formulierungen, Deutsche Apotheker Zeitung 131
(36), 1836-1837, 1991
(14) Müller, R. H., Waßmus, W., Smal, R., Koosha, F., Mikropartikel:
Mikrodepots zur kontrollierten Arzneistoffabgabe, Deutsche Apotheker Zeitung
131 (40), 2049-2051, 1991
(15) Rudt, S., Smal, R., Müller, R. H., Chemilumineszenz-Assay:
Untersuchung der Phagozytose von Arzneistoffträgern, Deutsche Apotheker Zeitung
132 (1/2), 10-11, 1992
(16) Rudt, S., Blunk, T., Müller, R. H., Quantification of Cell Subpopulations, Fractions of Dead Cells and Debris in Cell Suspensions by Laser Diffractometry, Pharm. Ind. 54 (11), 966-969, 1992
(17) Blunk, T. Mak, E., Müller, R. H., Characterization of Colloidal Drug Carriers: Determination of surface hydrophobicity by hydrophobic interaction chromatography, Pharm. Ind. 55 (6), 612-615, 1993
(18) Wallis, K. H., Müller, R. H., Determination of the Surface Hydrophobicity of Colloidal Dispersions by Mini-Hydrophobic Interaction Chromatography, Pharm. Ind. 55 (12), 1124-1128, 1993
(19) Wallis, K. H., Müller, R. H., Comparative Measurements of Nanoparticle Degradation Velocity using an Accelerated Hydrolysis Test, Pharm. Ind. 55 (2), 168-170, 1993
(20) Müller, R.H., Heinemann, S., Emulsions for Intravenous Administration. I. Emulsions for nutrition and drug delivery, Pharm. Ind. 55 (9), 853-856, 1993
(21) Müller, R.H., Heinemann, S., Emulsions for Intravenous Application. II. Destabilisation and stabilisation mechanisms in fat emulsions, Pharm. Ind. 55 (10), 948-953, 1993
(22) Schuhmann, R., Mehnert, W., Müller, R.H., Coulter
Counter Based Coalescence Assay for the Determination of Emulsion Stability
after Addition of Electrolyte, Pharm. Ind. 55 (7),
701-704, 1993
(23) Rudt, S.,
Müller, R.H., Messung der Chemilumineszenz zur Analytik und
In-vitro-Testung von Arzneiformen, Pharm. Ind.56 (4), 393-396, 1994
(24) Diederichs, J. E, Müller, R. H., Liposome in
Kosmetika und Arzneimitteln, Pharm. Ind. 56 (3),
267-275, 1994
(25) Huber, G.M.W., Becker, R., Müller, R.H.,
Zusammenhang zwischen Fließeigenschaften und Oberfläche pulverförmiger
Rezepturen, Pharm. Ind. 56 (4), 389-392, 1994
(26) Müller, R.H., Paulke, B.-R., Kolloide als
Arzneistoffträger in der Medizin,.Spektrum der
Wissenschaft, 102-106, 1994
(27) Müller, R.H., Mehnert, W., Neue Arzneimittel
mit Nanopartikeln - Innovationen in der Pharmazeutischen Technologie, Deutsche
Apotheker Zeitung 135, 2597-2601, 1995
(28) Schuhmann, R., Müller, R.H., Analytik
disperser Systeme mit Streulichtverfahren, Pharm. Ind.,
57 (7), 579-584, 1995
(29) Schuhmann, R., Müller, R.H., Analytik
disperser Systeme mit Streulichtverfahren, Österreichische Chemie 96, 198-203,
1995 (Nachdruck von Nr. 28)
(30) Schuhmann, R., Müller, R.H., Analytik
disperser Systeme mit Streulichtverfahren, Chemie-Plus 1/2, 53-58, 1996
(Nachdruck von Nr. 28)
(31) Weyhers, H., Mehnert, W., Müller, R.H., Analysis of
Particle Size Distribution of Micronized Lactose by Laser Diffractometry,
Pharm. Ind. 58 (4), 354-357, 1996
(32) Schütt, D., Schuhmann, R., Müller, R.H., Genauer
durch Mehrwinkelanalyse - Teilchengrößenmessung im Submikronbereich,
Chemie-Technik 9, 18-20, 1996
(33) Weyhers, H., Mehnert, W., Müller, R.H., Analysis of Particle Size Distribution of Micronized Lactose by Laser Diffractometry, Drugs made in Germany 40 (2), 1997 (Nachdruck von Nr. 31)
(34) Müller, R. H., Runge, S. A., Celowane podanie leku za pomoca koloidalnych nosników, Roczniki Naukowe, 1997
(35) Müller, R. H., Dingler, A., Feste
Lipid-Nanopartikel (Lipopearls™) als neuartiger
Carrier für kosmetische und dermatologische Wirkstoffe, Pharmazeutische Zeitung
49, Dermopharmazie, 11-15, 1998
(36) Müller, R. H., Dingler, A., The next generation after the liposomes: solid lipid nanoparticles (SLN™, Lipopearls™) as dermal carrier in cosmetics, Eurocosmetics 7/8, 19-26, 1998
(37) Müller, R. H., Harnisch, S., Characterization of fish vaccines and testing of administration properties, Bull. Eur. Ass. Fish Pathol. 18 (6), 209-219, 1998
(38) Müller, R. H., Olbrich, C., Solid Lipid Nanoparticles (SLN): Phyagocytic uptake, in vitro cytotoxity and in vivo biodegradation, Drugs made in Germany 42 (2), 49-53, 1999
(39) Kayser, O., Müller, R. H., Pharmazeutische
Biotechnologie, Deutsche Apotheker Zeitung 139 (45), 4339-4343, 1999
(40) Müller, R. H., The European Association of Pharma Biotechnology Satellite Meeting, Idrugs 3 No. 11, 2000
(41) Müller, R. H., Lipid-Nanopartikel (SLN, NLC) zur
Verkapselung von kosmetischen Wirkstoffen, Kosmetikjahrbuch, 481-484, 2003
(1) Müller, R. H., Müller, B. W. Davis, S. S., Amplitude Weighted Phase Structuration - a new Method for Simultaneous Charge and Size Determination of Colloidal Drug Carriers, Proceed. 4th International Conf. on Pharmaceutical Technology, 03. - 05.06. Paris, Vol. I, 205-214, 1986
(2) Müller, R. H., Davis, S. S., Illum, L. Mak, E., Surface Characterisation of Colloidal Drug Carriers Coated with Polymers, Macromolecular Reprints, 161-162, 1986
(3) Davies, M. C., Wright, J., Koosha, F., Müller, R. H., Davis, S. S., Surface Chemical Analysis and Site-Specific Delivery, Proceed. Int. Symp. Control. Rel. Bioact. Mater. 14, 111-112, 1987
(4) Müller, R. H., Heinemann, S. Niemann, W., Stability Determination of Parenteral Emulsions - a Comparison of Conventional and Laser Light Scattering Techniques, J. Pharm. Pharmacol. Suppl., 135, 1987
(5) Koosha, F., Müller, R. H., Washington, C., Production of Polyhydroxybutyrate (PHB) Nanoparticles for Drug Targeting, J. Pharm. Pharmacol. Suppl., 136, 1987
(6) Müller, R. H., Koosha, F., Davis, S. S. Illum, L., In Vitro and in Vivo Release of In-111 from PHB and PLA Nanoparticles, Proceed. Int. Symp. Control. Rel. Bioact. Mater. 15, 378-379, 1988
(7) Müller, R. H., Davis, S. S., Heinemann, S., Long-Term Stability of Regimens for Total Parenteral Nutrition, J. Pharm. Pharmacol. Suppl., 156, 1988
(8) Lucks, J. S., Müller, B. W., Stampa, B., Davis, S. S., Müller, R. H., Effect of Anti-Flocculants on Stability and Elimination of Aggregates in Suspensions, J. Pharm. Pharmacol. Suppl., 4, 1988
(9) Koosha, F., Müller, R. H., Davis, S. S., A Continous Flow System for In Vitro Evaluation of Drug-Loaded Biodegradable Colloidal Carriers, J. Pharm. Pharmacol. Suppl., 131, 1988
(10) Lherm, C., Müller, R. H., Herbort, J., Couvreur, P., Cytotoxicity of Polyalkylcyanoacrylate Particles of Increasing Alkyl Chain Length, 5th Int. Conf. on Pharm. Technol. (APGI) Vol. III, 81-88, 1989
(11) Diederichs, J. E., Weyhers, H., Müller, R. H., Parenteral fat emulsions I. Effects of emulsion composition on the microviscosity of the emulsifier film, Int. Symp. Control. Rel. Bioact. Mater. 18, 471-472, 1991
(12) Müller, R. H., Heinemann, S., Diederichs, J. E., Parenteral fat emulsions II: Charge and rigidity of emulsifier film related to the long-term stability, Int. Symp. Control. Rel. Bioact. Mater. 18, 469-470, 1991
(13) Müller, R. H., Rudt, S., Optimization of a chemiluminescence based cell culture assay to study the affinity of surface-modified drug carriers to macrophages, Int. Symp. Control. Rel. Bioact. Mater. 18, 219-220, 1991
(14) Carstensen, H., Müller, B. W., Müller, R. H., Characterization of the properties of parenteral fat emulsions related to their uptake by the RES, Int. Symp. Control. Rel. Bioact. Mater. 18, 473-474, 1991
(15) Lucks, J. S., Herbort, J., Chiannilkulchai, N., Müller, B. W., Couvreur, P., Müller, R. H., Water-soluble metallocene derivatives as antitumor agents - reduced in vivo toxicity of slowly decomposing complexes, Int. Symp. Control. Rel. Bioact. Mater. 18, 419-420, 1991
(16) Bock, T., Müller, R. H., Müller, B. W., A new assay for determining the hemolytic activity of drugs incorporated in emulsions and liposomes, 6th Int. Conf. on Pharm. Technol. (APGI), Vol. VI, 380-387, 1992
(17) Diederichs, J. E., Mehnert, W., Lucks, J. S., Müller, R. H., Microviscosity measurements for the optimization of liposomes and emulsion formulations, 6th Int. Conf. on Pharm. Technol. (APGI), Vol. V, 138-147, 1992
(18) Lucks, J. S., Diederichs, J. E., Müller, B. W., Müller, R. H., Preparation and stability of sterically stabilized soya oil emulsions, 6th Int. Conf. on Pharm. Technol. (APGI), Vol. V, 148-153, 1992
(19) Lucks, J. S., Baratt, G., Müller, B. W., Couvreur, P., Müller, R. H., Targeted controlled release formulations of titanocene dichloride for the treatment of liver metastasis, 6th Int. Conf. on Pharm. Technol. (APGI), Vol. II, 317-321, 1992
(20) Müller, R. H., Lucks, J. S., Diederichs, J. E., Heinemann, S., Egg lecithin stabilized emulsions for parenteral nutrition - a three year stability study, 6th Int. Conf. on Pharm. Technol. (APGI), Vol. IV, 351-360, 1992
(21) Diederichs, J. E., Mehnert, W., Müller, R. H., Differential Scanning Calorimetry of parenteral fat emulsions, 6th Int. Conf. on Pharm. Technol. (APGI), Vol. IV, 361-369, 1992
(22) Müller, R. H., Blunk, T., Carstensen, H., Müller, B. W., Comparison of the physicochemical properties of surface-modified colloidal drug carriers and fat emulsions for intravenous injection, 6th Int. Conf. on Pharm. Technol. (APGI), Vol. V, 174-184, 1992
(23) Blunk, T., Hochstrasser, D. F., Müller, B.W., Müller, R.H., Differential adsorption: Effect of plasma protein adsorption patterns on organ distribution of colloidal drug carriers, Int. Symp. Control. Rel. Bioact. Mater. 20, 256-257, 1993
(24) Blunk, T., Hochstrasser, D. F., Müller, B.W., Müller, R.H., 2-D PAGE analysis of plasma protein adsorption on colloidal drug carriers, Int. Symp. Control. Rel. Bioact. Mater. 20, 284-285, 1993
(25) Diederichs, J.E., Müller, R.H., Microviscosity of bovine surfactant liposomes for the treatment of IRDS, Int. Symp. Control. Rel. Bioact. Mater. 20, 488-489, 1993
(26) Diederichs, J.E., Müller, R.H., Production and characterization of bovine surfactant liposomes for the treatment of IRDS, Int. Symp. Control. Rel. Bioact. Mater. 20, 482-483, 1993
(27) Müller, R.H., Schwarz, C., Mehnert, W., Lucks, J.S., Production of solid lipid nanoparticles (SLN) for controlled drug delivery, Int. Symp. Control. Rel. Bioact. Mater. 20, 480-481, 1993
(28) Maaßen, S., Schwarz, C., Mehnert, W., Lucks, J.S., Yunis-Specht, F., Müller, B.W., Müller, R.H., Comparison of cytotoxicity between polyester nanoparticles and solid lipid nanoparticles (SLN), Int. Symp. Control. Rel. Bioact. Mater. 20, 490-491, 1993
(29) Müller, R.H., Schwarz, C., zur Mühlen, A., Mehnert, W., Incorporation of Lipophilic Drugs and Drug Release profiles of Solid Lipid Nanoparticles (SLN), Int. Symp. Control. Rel. Bioact. Mater. 21, 146-147, 1994
(30) Blunk, T., Bock, T.K., Hochstrasser, D.F., Sanchez, J.C., Müller, B.W., Müller, R.H., Plasma Protein Adsorption Patterns on Fat Emulsions compared to Modified Latex Particles, Int. Symp. Control. Rel. Bioact. Mater. 21, 503-504, 1994
(31) Diederichs, J.E., Vauthier, C., Alphandary, H., Couvreur, P., Müller, R.H., Formation Process and Determination of Microviscosity of Alginate Nanoparticles, Int. Symp. Control. Rel. Bioact. Mater. 21, 511-512, 1994
(32) Blunk, T., Lück, M., Hochstrasser, Sanchez, J.C., Müller, B.W., Müller, R.H., Kinetics of Protein Adsorption on Colloidal Drug Carriers for Drug Targeting. Evaluation by HR-Two-Dimensional Polyacrylamide Gel Electrophoresis, Proc. of 2D Electrophoresis: from protein maps to genomes, Siena, Italien, 100-101, 1994
(33) Herbort, J., Diederichs, J.E., Müller, R.H., Particle size analysis of liposomes in hydrogels by photon correlation spectroscopy (PCS), 1st World Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, APGI/APV, Budapest, 555-556, 1995
(34) Bucke, W.E., Ehlers, S., Leitzke, S., Diederichs, J.E., Hahn, H., Müller, R.H., Optimized liposomal amikacin for treatment of disseminated mycobacterial infections, 1st World Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, APGI/APV, Budapest, 545-546, 1995
(35) Müller, R.H., Mehnert, W., Potential of Solid Lipid Nanoparticles (SLN) for Controlled Drug Delivery, 1st World Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, APGI/APV, Budapest, 463-464, 1995
(36) Weyhers, H., Ehlers, S.,Mehnert, W.,Hahn, H., Müller, R.H., "Solid Lipid Nanoparticles" - determination of in vivo toxicity, 1st World Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, APGI/APV, Budapest, 489-490, 1995
(37) Rühl, D., Paulke, B.-R., Maurer, H.R., Müller, R.H., Phagocytic uptake of polymeric particles in vitro - effect of surface hydrophobicity and fluorescent labeling, 1st World Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, APGI/APV, Budapest, 525-526, 1995
(38) Eckstein, B., Diederichs, J.E., Burger, J.J., Sloot, E.A., Müller, R.H., Analytical approach to determine the effect of azo dyes on the physical stability of stabilized o/w emulsions, 1st World Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, APGI/APV, Budapest, 660-661, 1995
(39) Müller, R.H., Peters, K., Becker, R., Kruss, B., Nanosuspensions - a novel formulation for the i.v. administration of poorly soluble drugs, 1st World Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, APGI/APV, Budapest, 491-492, 1995
(40) Freitas, C., Lucks, J.S., Müller, R.H., Effect of storage conditions on long-term stability of "Solid Lipid Nanoparticles" (SLN) in aqueous dispersion, 1st World Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, APGI/APV, Budapest, 493-494, 1995
(41) Thode, K., Kresse, M., Pfefferer, D., Semmler, W., Müller, R.H., Mini-HIC for the determination of the surface hydrophobicity of magnetite dispersions, 1st World Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, APGI/APV, Budapest, 509-510, 1995
(42) Kresse, M., Pfefferer, D., Thode, K., Müller, R.H., Semmler, W., Estimation of hydrodynamic sizes of dextran coated iron oxide nanoparticles by size exclusion chromatography (SEC), 1st World Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, APGI/APV, Budapest, 507-508, 1995
(43) Blunk, T., Lück, M., Müller, B.W., Müller, R.H., Influence of polyethylene oxide chains on the protein adsorption on nanoparticles for drug targeting, 1st World Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, APGI/APV, Budapest, 531-532, 1995
(44) Müller, R.H., Peters, K., Becker, R., Kruss, B., Nanosuspensions for the i.v. Administration of Poorly Soluble Drugs - Stability During Sterilization and Long-Term Storage, Int. Symp. Control. Rel. Bioact. Mater. 22, 574-575, 1995
(45) Diederichs, J.E., Eckstein, B., Müller, R.H., Influence of Divalent Cations on the Coalescence Kinetics of Parenteral Fat Emulsions - Fusion Properties of Calcium Ions, Int. Symp. Control. Rel. Bioact. Mater. 22, 378-379, 1995
(46) Blunk, T., Lück, M., Diederichs, J.E., Müller, B.W., Müller, R.H., Plasma Protein Adsorption on Polystyrene Particles of Different Size Modified with Poloxamer 407, Int. Symp. Control. Rel. Bioact. Mater. 22, 47-48, 1995
(47) Schwarz, C., Freitas, C., Mehnert, W., Müller, R.H., Sterilization and Physical Stability of Drug-Free and Etomidate-Loaded Solid Lipid Nanoparticles, Int. Symp. Control. Rel. Bioact. Mater. 22, 766-767, 1995
(48) Peters, K., Müller, R.H., Nanosuspensions for the oral application of poorly soluble drugs, Proceeding European Symposium on Formulation of Poorly-available Drugs for Oral Administration, APGI, Paris, 330-333, 1996
(49) Müller, R.H., Peters, K., Craig, D., Electron microscopic studies of nanosuspensions - particle shapes as a funktion of drug and surfactant, Int. Symp. Control. Rel. Bioact. Mater. 23, 925-926, 1996
(50) Müller, R.H., zur Mühlen, A., Freitas, C., Solid Lipid Nanoparticles (SLN) for intravenous drug delivery, Int. Symp. Control. Rel. Bioact. Mater. 23, 184-185, 1996
(51) Diederichs, W.E., Leitzke, J.E., Bucke, S., Borner, K., Ehlers, S., Hahn, H., Müller, R.H.,
Superiority of Liposomal Amikacin - A comparison with free drug admixed to
colloidal carriers, Int. Symp. Control.
Rel. Bioact. Mater. 23, 659-660, 1996
(52) Schuhmann R., Müller, R.H., Optimierung der
Probenaufbereitung für Coulter-Counter-Messungen, Proceedings Seminar mit
Praktikum: Probenpräparation und Partikelmeßtechnik,
George-Simon-Ohm-Fachhochschule Nürnberg, Fachbereich Verfahrenstechnik und
Coulter Electronics GmbH, 25./26.6.1996
(53) Pistel, K.F., Lück, M., Müller, R.H. and Kissel, T., Plasma Protein Adsorption on Biodegradable Microspheres Consisting of Polyesters or ABA Triblock Copolymers, Int. Symp. Control. Rel. Bioact. Mater. 24, 765-766, 1997
(54) Almeida, A.J., Runge, S., Müller, R.H., Investigations on solid lipid nanoparticles (SLN) as colloidal carriers for protein antigens, Int. Symp. Control. Rel. Bioact. Mater. 24, 837-838, 1997
(55) Diederichs, J.E., Herbort, J., Müller, R.H., Long-term stability of liposomes in hydrogels, Int. Symp. Control. Rel. Bioact. Mater. 24, 845-846 (1997)
(56) Harnisch, S., Müller, R.H., Analysis of adsorbed plasma proteins on commercial emulsions for parenteral nutrition, Int. Symp. Control. Rel. Bioact. Mater. 24, 847-848, 1997
(57) Lück, M, Schröder, W., Paulke, B.-R., Müller, R.H., Identification of plasma proteins adsorbed on polystyrene model particles, Int. Symp. Control. Rel. Bioact. Mater. 24, 849-850, 1997
(58) Müller, R.H., Peters, K., Nanosuspensions - based drug formulations - a solution for poorly soluble & bioavailable drugs, Int. Symp. Control. Rel. Bioact. Mater. 24, 863-864, 1997
(59) Olbrich, C., Mehnert, W., Müller, R.H., Effect of
surfactant and lipid composition on the in vitro degradation time of solid
lipid nanoparticles (SLN), Int. Symp. Control. Rel. Bioact. Mater. 24, 921-922, 1997
(60) Müller, R.H., Mehnert, W., Dingler, A., Runge, S.A., zur Mühlen, A., Freitas, A., Solid lipid nanoparticles (SLN™, Lipopearls™) - present state of development, Int. Symp. Control. Rel. Bioact. Mater. 24, 923-924, 1997
(61) Dingler, A., Hildebrand, G.E., Kielholz, J., Pfeiffer, S., Debus, N., Müller, R.H., Gohla, S., Electron and fluorescence micrographical characterisation of lipopearls™ (SLN™), Int. Symp. Control. Rel. Bioact. Mater. 24, 925-926, 1997
(62) Böhm, B.H.L., Behnke, D., Müller, R.H., Production of paclitaxel nanosuspensions by high-pressure homogenisation, Int. Symp. Control. Rel. Bioact. Mater. 24, 927-928, 1997
(63) Harnisch, S., Schuhmann, R., Müller, R.H., Calcium-induced coalescence-effect of emulsion dilution on coalescence kinetices, Int. Symp. Control. Rel. Bioact. Mater. 24, 929-930, 1997
(64) Müller, R.H., Diederichs, J.E., Bucke, W.E., Controlled enhancement of drug incorporation into liposomes by ascorbic acid palmitate (AP), retinol palmitate (RP) and tocopherol acetate (TA), Int. Symp. Control. Rel. Bioact. Mater. 24, 931-932, 1997
(65) Hildebrand, G.E., Herbort, J., Diederichs, J.E., Müller, R.H., Fluorescence polarization studies in micelles to monitor changes in colloidal structures, Int. Symp. Control. Rel. Bioact. Mater. 24, 933-934, 1997
(66) Dingler, A., Lukowski, G., Pflegel, P., Müller, R.H., Gohla, S., Production and characterisation of lipopearls™ for cosmetics, Int. Symp. Control. Rel. Bioact. Mater. 24, 935-936, 1997
(67) Lück, M., Pistel, K.F., Kissel, T., Müller, R.H., Influence of the production method on protein adsorption of biodegradable microspheres, Int. Symp. Control. Rel. Bioact. Mater. 24, 937-938, 1997
(68) Müller, R.H., Peters, K., Craig, D., Investigations of nanosuspensions with low-frequency dielectric analysis, Int. Symp. Control. Rel. Bioact. Mater. 24, 991-992, 1997
(69) Kresse, M., Wagner, S., Philipp, K., Thode, K., Müller, R.H., Semmler, W, Synthesis and Properties of Dexrtran-coated Iron Oxides for Lymph Node Targeting, Int. Symp. Control. Rel. Bioact. Mater. 24, 93-94, 1997
(70) Harnisch, S.. Schuhmann, R., Thode, K., Müller, R.H., Improvements on particle sizing using a laser diffractometer equipped with the PIDS technology, 2nd World Congress on Emulsion, Bordeaux, 2-1-197, 1997
(71) Dingler, A., Lukowski, G., Pflegel, P., Gohla, S., Müller, R.H., Production of solid lipid nanoparticles (SLNTM) from cosmetic lipids and surfactants, 2nd World Congress on Emulsion, Bordeaux, 4-2-297, 1997
(72) Harnisch, S., Blunk, T., Müller, R.H., Analysis of plasma protein adsorption on commercial emulsions for intravenous parenteral nutrition, 2nd World Congress on Emulsion, Bordeaux, 4-2-199, 1997
(73) Dingler, A., Lukowski, G., Gohla, S., Müller, R.H., Production and characterisation of solid lipid nanoparticles as colloidal carrier system for cosmetic products, 2nd World Congress on Emulsion, Bordeaux, 4-2-296, 1997
(74) Dingler, A., Hildebrand, G.E., Kielholz, J., Gohla, S., Müller, R.H., Fluorescence and electron microscopic characterisation of solid lipid nanoarticles in aqueous dispersions and ointments, 2nd World Congress on Emulsion, Bodeaux, 4-2-297, 1997
(75) Müller, R.H., Gohla, S., Hildebrand, G., Runge, S.A., Dingler, A, Dispersion of solid lipid nanoparticles (SLN): Production and possible applications in food, cosmetic and pharmaceutical products, 2nd World Congress on Emulsion, Bordeaux, 1-2-195, 1997
(76) Harnisch, S., Schuhmann, R., Müller, R.H., A Coulter Counter based assay for high resolution analysis of the coalescence kinetics of oil-in-water emulsions, 2nd World Congress on Emulsion, Bordeaux, 2-3-198, 1997
(77) Böhm, B.H.L., Grau, M.J., Hildebrand, G.E., Thünemann, A.F., Müller, R.H., Preparation and Physical Properties of Nanosuspensions (Dissocubes™) of Poorly Soluble Drugs, Int. Symp. Control. Rel. Bioact. Mater. 25, 956-957, 1998
(78) Müller, R.H., Dingler, A., Hildebrand, G.E., Gohla, S., Development of Cosmetic Products (Lipopearls™) based on Solid Lipid Nanoparticles, Int. Symp. Control. Rel. Bioact. Mater. 25, 238-239, 1998
(79) Dingler, A., Hildebrand, G., Niehus, H., Müller, R.H., Cosmetic Anti-Aging Formulation Based on Vitamin E-Loaded Solid Lipid Nanoparticles, Int. Symp. Control. Rel. Bioact. Mater. 25, 433-434, 1998
(80) Hildebrand, G.E., Dingler, A., Runge, S.A., Müller, R.H., Medium Scale Production of Solid Lipid Nanoparticles (SLN), Int. Symp. Control. Rel. Bioact. Mater. 25, 968-969, 1998
(81) Haeckel, S., Sachse, A., Albayrak, C., Müller, R.H., Preparation and characterization of insulin-loaded PLGA-microcapsules produced by the induced phase separation method, 2nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 507-508, 1998
(82) Dingler, A., Müller, R.H., Gohla, S., Incorporation of Hydrophilic Active Ingredients in Solid Lipid Nanoparticles for the Topical Application, 2nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 625-626, 1998
(83) Harnisch, S., Buszello, K., Müller, B.W., Müller, R.H., Influence of the Composition of Oil in Water Emulsions on the Pattern of Adsorbed Plasma Proteins, 2nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 773-774, 1998
(84) Olbrich, C., Mehnert, W., Müller, R.H., In vitro Degradation Properties of Solid Lipid Nanoparticles SLN™, 2nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 577-578, 1998
(85) Olbrich, C., Mehnert, W., Müller, R.H., Development of an in vitro Degradation Assay for Solid Lipid Nanoparticles, 2nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 627-628, 1998
(86) Schütt, D.H., Kaiser, Stamm, I., Kubis, A., E., Müller, R.H., New Generation of Cosmetic Products Based on Solid Lipid Nanoparticles (Lipopearls™), 2nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 585-586, 1998
(87) Jenning, V., Gohla S., Müller R.H., Solid Lipid Nanoparticles (SLN): Effect of homogenization parameters on drug stability, 2nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 619-620, 1998
(88) Böhm, B.H.L, Behnke, D., Müller, R.H., Paclitaxel Nanosuspensions: Production, Lyophilisation and Stability, 2nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 621-622, 1998
(89) Grau, M.J., Müller, R.H., Increase of Dissolution Velocity and Solubility of Poorly Soluble Drugs by Formulation as Nanosuspension, 2nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 623-624, 1998
(90) Geßner, A., Lück, M., Paulke, B.R., Müller, R.H., Analysis of Plasma Protein Adsorption on Model Particles by Two-Dimensional Electrophoresis - Methodical Aspects, 2nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 615-616, 1998
(91) Seehof, K., Harnisch, S., Kresse, M, Semmler, W., Müller, R.H., Protein Adsorption Patterns on to Iron Oxide MRI Contrast Media, Results for Citrated and Heparinized Human Plasma, 2nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 617-618, 1998
(92) Peters, K., Leitzke, S., Ehlers, S., Borner, K., Hahn, H., Müller, R.H., Preparation of a clofazimine nanosuspension for i.v. administration, 2nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 609-610, 1998
(93) Lück, M., Schröder, W., Paulke, B.R., Müller, R.H., Binding of Complement Protein C3 to Model Drug Carriers for i.v. Application - Determination by 2-D Electrophoresis, 2nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 607-608, 1998
(94) Anger, S., Mehnert, W., Caldwell, K., Müller, R.H., High resolution determination of adsorption layer mass on particles by sedimentation field-flow fractionation, 2nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 643-644, 1998
(95) Kresse, M., Thode, K., Wagner, S., Müller, R.H., Semmler, W., Ex vivo investigations into the opsonization of iron-oxide-based contrast media for MRI, 2nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 611-612, 1998
(96) Kresse, M., Thode, K., Müller, R.H., Multi-angle and two-time window analysis: detection of aggregates in iron-oxide dispersions, 2nd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Paris, 37-38, 1998
(97) Krause, W., Schlichter, N., Maier, F. K., Sachse, A., Müller, R. H., Contrast Agents Based on Dendrimers and Vesicles, DECHEMA Symposion „Polymers for Medicinal Technologies, Tutzing, 8-11 March 1999
(110) Baudisch, U. Briel, A., Rößling, G., Müller, R. H., Investigation of the glass transition temperature of polybutylcyanoacrylate polymers, 3rd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology APGI/APV, Berlin, 423-424, 2000
(1) Müller, R.H., Müller, B.W.,
Teilchengrößenbestimmungen an Mikroemulsionen mit Hilfe der Laser-Korrelationsspektroskopie,
Acta Pharm. Technol. 28, 91, 1982
(2) Müller, B.W., Müller, R.H., Schulz-DuBois, E.O., Zetapotentialmessungen an hochdispersen Systemen mit Hilfe der Laser Doppler Anemometrie, Acta Pharm. Technol. 28, 90, 1982
(3) Müller,
R.H., Mak, E., Analysis of
Particle Charge and Surface Hydrophobicity of Colloidal Drug Carriers. NATO
Advanced Studies Institute Meeting "Targeting of Drugs with Synthetic
Systems", 24.06.-25.07. Cape Sounion Beach (Greece), 1985
(4) Davis, S.S., Illum, L., Mak, E., Müller, R.H., AWPS zur Ladungsbestimmung kolloider Arzneistoffträger, Arch. Pharm.318, 1985
(5) Müller, R.H., Davis, S.S., Illum, L., Mak, E., Colloidal Carriers for Drug Targeting - Charge Reduction by Coating with Polymers, Acta Pharm. Technol. 32, 1986
(6) Mak, E., Davis,
S.S., Illum, L., Müller, R.H., Determination of the Surface
Hydrophobicity of Colloidal Drug Carriers using a Rose Bengal Binding Method,
Acta Pharm. Technol. 32, 1986
(7) Müller, R.H., Davis, S.S., Nehne, J., Vergleich von Analysenmethoden zur
Stabilitätsuntersuchung von parenteralen Fettemulsionen, Gemeinsame Tagung der
Österreichischen und Deutschen Pharmazeutischen
Gesellschaft, 10.-12.06. Innsbruck, Scientia Pharmaceutica 3, 224, 1986
(8) Müller, R.H., West, P.E., Koosha, F., Davis, S.S., Coulter Counter und Laserdiffraktometer - Vergleich der beiden Meßmethoden, Gemeinsame Tagung der Österreichischen und Deutschen Pharmazeutischen Gesellschaft, 10.-12.06. Innsbruck, Scientia Pharmaceutica 3, 225, 1986
(9) Mak, E., Davis, S.S., Illum, L., Müller, R.H., Determination of Surface Properties of 'Standard' Latex Particles, British Pharmaceutical Conference, 22.-24.09. Jersey, 100, 1986
(10) Müller, R.H., Davies, M.C., Koosha, F., Surface Analysis of PHB Drug Carriers by SSIMS, 2nd Int. Conference on Biointeractions, 06.-08.07. Cambridge, 1987
(11) Müller,
R.H., Mak, E., Davis, S.S., Cairns, S.,
Aqueous Two Phase Partitioning for the Surface Characterisation of Colloidal
Drug Carriers. 5th Int. Conference on Phase Partitioning, 24.-28.08. Oxford,
1987
(12) Müller, R.H., Drug Targeting mit kolloidalen Carriern - Limitationen und Möglichkeiten, Arch. Pharm. 320, 912, 1987
(13) Müller, R.H., Wowk, I., Controlled Surface Modification of Model Drug Carriers, Arch. Pharm. 320, 982, 1987
(14) Koosha, F., Müller, R.H., Production of Polyhydroxybutyrate (PHB) Micro- and Nanoparticles, Arch. Pharm. 320, 913, 1987
(15) Müller, R.H., Koosha, F., Davies, M.C., Determination of Toxic Residues in Drug Carriers by SSIMS, Arch. Pharm. 320, 980, 1987
(16) Galazka, V., Khan,
A.M., Davies, M.C., Müller, R.H., Effect of Gamma Iridation and Plasma Etching on the Surface of Polymers,
Arch. Pharm. 320, 983, 1987
(17) Müller, R.H., Heinemann, S., Stabilitätsuntersuchungen an TPN-Regimen, Arch. Pharm. 320, 981, 1987
(18) Koosha, F., Müller, R.H., Radioactive Labelling of Biodegradable PHB and PLA Drug Carriers, Acta Pharm. Technol. 34, 24S, 1988
(19) Koosha, F., Müller, R.H., Production of Polymeric Drug Carriers for Drug Targeting, Acta Pharm. Technol. 34, 24S, (1988)
(20) Müller, R.H., Nehne, J., Davis, S.S., Heinemann, S., Characterization of Fat Emulsions for Parenteral Nutrition, Acta Pharm. Technol. 34, 23S, 1988
(21) Müller, R.H., Davis, S.S., Niemann, W., Stability Assessment of Feeding Mixtures for Parenteral Nutrition (TPN), Acta Pharm. Technol. 34, 17S, 1988
(22) Davies, M.C., Koosha, F., Müller, R.H., The Surface Analysis of Micro- and Nanoparticles by SSIMS, Acta Pharm. Technol. 34, 21S, 1988
(23) Mak, E., Müller, R.H., Davis, S.S., Illum, L., Hydrophobic Interaction Chromatography (HIC) and Laser doppler Anemometry (LDA) for the Characterization of Coated Drug Carriers, Acta Pharm. Technol. 34, 23S, 1988
(24) Mak, E., Müller, R.H., Davis, S.S., Illum, L., Characterization of Colloidal Carriers for Drug Targeting, Acta Pharm. Technol. 34, 20S, 1988
(25) Müller, B.W., Lucks,J.S., Stampa, B., Müller, R.H., Effect of Anti-Flocculating Agents on the Zeta Potential of Dispersions, Acta Pharm. Technol. 34, 23S, 1988
(26) Müller, B.W., Stampa, B., Lucks, J.S., Müller, R.H., AWPS - Zeta Potential Measurements in Low Electrical Fields under the Elimination of the Stationary Layer, Acta Pharm. Technol. 34, 23S, 1988
(27) Bräuer, A., Wollesen, C., Jones, P.D.E., Müller, R.H., Hepatocyte Cultures for the Testing of Colloidal Drug Delivery Systems, Arch. Pharm 321, 684, 1988
(28) Müller, R.H., Lucks, J.S., Davis, S.S., Wallis, K., Long Term Stability of Parenteral Fat Emulsions, Arch. Pharm 321, 676, 1988
(29) Müller, R.H., Blunk, T., Koosha, F., Davis, S.S., Determination of Surface Hydrophobicity of Colloidal Polymeric and Emulsion Drug Carriers, Arch. Pharm 321, 677, 1988
(30) Müller, R.H., Blunk, T., Koosha, F., Determination of the Thickness of Adsorbed Polymer Layers on Colloidal Drug Carriers by Charge Measurements, Arch. Pharm 321, 678, 1988
(31) Roberts, M.J.J., Müller, R.H., Gupta, A., Williams, P., Davies, M.C., Davis, S.S., The Production of Monodisperse Polystyrene Latexes of a Range of Nominal Particle Sizes, Arch. Pharm 321, 679, 1988
(32) Koosha, F., Müller, R.H., Nanoparticle Production by Microfluidization, Arch. Pharm 321, 680, 1988
(33) Lucks,
J.S., Müller, B.W., Müller, R.H., Effect of Electrolytes on the
Stability of Parenteral Fat Emulsions, Arch. Pharm 321, 683,
1988
(34) Müller, B.W., Lucks, J.S., Müller, R.H., Effektivität des Peptisatorzusatzes nach DIN 51033 zur Stabilitätserhöhung von Suspensionen, Arch. Pharm 321, 616, 1988
(35) Lherm, C., Müller, R.H., Blunk, T., Perie, M., Depraetere, P., Couvreur, P., Physico-Chemical Characterisation of Cyanoacrylate Particles, Arch. Pharm 321, 682, 1988
(36) Müller, R.H., Lherm, C., Jaffray, P., Couvreur, P., Toxicity of Cyanoacrylate Particles in L929 Fibroblast Cell Cultures - Relation between Toxicity and In Vitro Characterization Parameters, Arch. Pharm 321, 681, 1988
(37) Müller, R.H., Lucks, J.S., Relevance of Stress Tests for the Estimation of the Long-term Stability of Parenteral Fat Emulsions, Arch. Pharm 321, 685, 1988
(38) Müller, R.H., Koosha, F., In Vitro Characterization of i.v. Drug Carriers - a New Theory of the Relevant Factors Determining Their In Vivo Behaviour, Arch. Pharm 321, 622, 1988
(39) Müller, R.H., Blunk, T., Properties of Poloxamer and Poloxamine Coating Layers on Different Sized Polystyrene Model Drug Carriers, Arch. Pharm 322, 699, 1989
(40) Müller, R.H., Differential Opsonization - a New Approach for the Targeting of Colloidal Drug Carriers, Arch. Pharm 322, 700, 1989
(41) Lucks, J.S., Müller, B.W., Müller, R.H., Stability of Mixed Emulsion Systems Containing Egg Lecithin and Ethoxylated Surfactants, Arch. Pharm 322, 704, 1989
(42) Bräuer, A., Aschmann, C., Müller, R.H., Ethoxylated Surfactants for the Coating of Colloidal Drug Carriers - Interaction with Hepatocytes in Culture, Arch. Pharm. 322, 754, 1989
(43) Blunk, T., Müller, R.H., Uptake of Charged Serum Components as a Selection Criterion for i.v. Drug Carriers Avoiding Liver / Spleen Uptake, Arch. Pharm. 322, 755, 1989
(44) Lherm, C., Herbort, J., Müller, R.H., Couvreur, P., Fluorescent Labelling of Polyalkylcyanoacrylate Particles - Optimization of Labelling Conditions, Arch. Pharm. 322, 760, 1989
(45) Müller, R.H., Landry, F.B., Characterization of Aluminum Hydroxide Suspensions by Laser Light Scattering Techniques, Arch. Pharm. 322, 762, 1989
(46) Lherm, C., Herbort, J., Müller, R.H., Couvreur, P., In Vitro Degradation of Polyalkylcyanoacrylate Particles - Influence of Alkyl Chain Length and Incubation Medium, Arch. Pharm. 322, 763, 1989
(47) Lucks, J.S., Müller, B.W., Müller, R.H., Microfluidizer and Micron Lab 40 - Influence of Homogenization Parameters on Particle Size, Arch. Pharm. 322, 764, 1989
(48) Müller, R.H., Wallis, K.H., Stability of Poloxamer and Poloxamine Coating Films on Colloidal Drug Carriers, Arch. Pharm. 322, 768, 1989
(49) Wallis, K.H., Müller, R.H., In Vitro Degradation Model for PLA, PLA/GA and PHB Nanoparticles, Arch. Pharm. 322, 769, 1989
(50) Lherm, C., Müller, R.H., Couvreur, P., Cytotoxicity of Polyalkyl-Cyanoacrylate Particles in L929 Fibroblast Cultures - Mechanism of the Toxic Effect, Arch. Pharm. 322, 682, 1989
(51) Müller, R.H., Differential adsorption for the targeting of drug carriers, Acta Pharm. Technol. 36, 34S, 1990
(52) Wallis, K., Müller, R.H., Surface-modified colloidal drug carriers - determination of the dysopsonic effect by PCS, Acta Pharm. Technol. 36, 34S, 1990
(53) Blunk, T., Müller, R.H., Measurement of the surface hydrophobicity of parenteral fat emulsions as an important parameter for RES impairment, Acta Pharm. Technol. 36, 34S, 1990
(54) Lherm, C., Herbort, J., Müller, R.H., Couvreur, P., Degradation studies on surface-modified alkyl-cyanoacrylate nanoparticles, Acta Pharm. Technol. 36, 33S, 1990
(55) Bräuer, A., Lherm, C., Couvreur, P., Müller,
R.H., Cytotoxicity of alkyl-cyanoacrylate nanoparticles in
fibroblast and hepatocyte cultures, Acta Pharm. Technol. 36, 33S,
1990
(56) Lucks, J.S., Müller, B.W., Müller, R.H.,
Wechselwirkungen parenteraler Fettemulsionen mit Peptisatoren,
Acta Pharm. Technol. 36, 33S, 1990
(57) Stampa, B., Lucks, J.S., Müller, B.W., Müller, R.H., Polarisationsdekodierte AWPS - Simultane Messung von Zetapotential und Teilchengrößenverteilung, Acta Pharm. Technol. 36, 33S, 1990
(58) Müller, R.H., Herbort, J., Production of polystyrene particles and particles with incorporated gold core for use as model drug carriers, Arch. Pharm. 323, 775, 1990
(59) Wallis, K.H., Müller, R.H., Mini-HIC for the rapid determination of the surface hydrophobicity of colloidal particles, Arch. Pharm. 323, 766, 1990
(60) Carstensen, H., Müller, B.W., Müller, R.H., Microcalorimetric studies of the adsorption of ethoxylated surfactants on polystyrene particles, Arch. Pharm. 323, 776, 1990
(61) Bräuer, A., Müller, R.H., Toxicity of cyanoacrylate nanoparticles, degradation products and Doxorubicin-containing particles, Arch. Pharm. 323, 763, 1990
(62) Rudt, S., Bräuer, A., Veit, A., Maurer, R., Müller, R.H., Chemiluminescence for the testing of particulate drug carriers in cell suspension, Arch. Pharm. 323, 774, 1990
(63) Müller, R.H., Heinemann, S., PCS and zeta potential characterization of model particles and colloidal drug carriers - essential information for the interpretation of cell culture studies, Biochem. Soc. Trans. 19, 1991
(64) Lucks, J.S., Müller, B.W., Müller, R.H., Influence of sterically stabilizing agents on the stability of fat emulsions, J. Pharm. Pharmacol. Suppl., 137p, 1991
(65) Diederichs, J.E., Weyhers, H., Müller, R.H., Microviscosity of egg lecithin films in Lipofundin fat emulsions, Arch. Pharm. 324, 692, 1991
(66) Müller, R.H., Lucks, J.S., Herbort, J., Couvreur, P., Improved treatment of liver metastasis by titanocene dichloride using an emulsion carrier, Arch. Pharm. 324, 693, 1991
(67) Müller, R.H., Heinemann, S., Stability of TPN-regimens based on Lipofundin / Intralipid containing a high electrolyte load, Arch. Pharm. 324, 694, 1991
(68) Blunk, T., Hochstrasser, D.F., Rudt, S., Müller, R.H., Two-dimensional electrophoresis in the concept of differential opsonization - an approach to drug targeting, Arch. Pharm. 324, 706, 1991
(69) Müller, R.H., Rudt, S., Increased sensitivity of the chemiluminescence assay for phagocytosis by optimized analytical parameters, Arch. Pharm. 324, 714, 1991
(70) Diederichs, J.E., Müller, R.H., Determination of the microviscosity of surfactant films and phospholipid layers, Arch. Pharm. 324, 607, 1991
(71) Fjellestad, A.G., Lucks, J.S., Waaler, T., Müller, B.W., Müller, R.H., Measurement of interfacial tensions as a tool to optimize the development of emulsions as intravenous drug carrier systems, Arch. Pharm. 324, 640, 1991
(72) Müller, R.H., Characterization of Nanoparticles, Fat Emulsions and Inorganic Suspensions by Zetapotential Measurements, Malvern Instruments Zetapotential-Workshop, Budapest, 28.1.1992
(73) Lucks, J.S., Müller, B.W., Diederichs, J.E., Müller, R.H., Effect of minor components on emulsion stability investigated by mixture model design, Eur. J. Pharm. Biopharm. 38, 10S, 1992
(74) Müller, R.H., Bräuer, A., Cytotoxicity of cyanoacrylate nanoparticles in hepatocyte culture determined by cellular LDH and potassium release, Eur. J. Pharm. Biopharm. 38, 14S, 1992
(75) Blunk, T., Hochstrasser, D.F., Müller, R.H., Plasma component adsorption patterns on colloidal drug carriers - determination by two-dimensional electrophoresis, Eur. J. Pharm. Biopharm. 38, 32S, 1992
(76) Maaßen, S., Müller, R.H., Assessment of cytotoxicity by chemiluminescence assay of the phagocytic activity, Eur. J. Pharm. Biopharm. 38, 32S, 1992
(77) Diederichs, J.E., Mehnert, W., Lucks, J.S., Müller, R.H., DSC investigations of parenteral fat emulsions, Eur. J. Pharm. Biopharm. 38, 32S, 1992
(78) Lucks, J.S., Müller, R.H., König, B., Solid lipid nanoparticles (SLN) - an alternative parenteral drug delivery system, Eur. J. Pharm. Biopharm. 38, 33S, 1992
(79) Lukowski, G., Müller, R.H., Müller, B.W., Dittgen, M., Surface characterization of acrylic acid copolymer nanoparticles for drug delivery, Eur. J. Pharm. Biopharm. 38, 41S, 1992
(80) Bock, T.K., Müller, R.H., Müller, B.W., A new test for determining the hemolytic activity of drugs incorporated in colloidal carriers, Eur. J. Pharm. Biopharm. 38, 42S, 1992
(81) Schuhmann, R., Mehnert, W., Müller R.H., Coalescence
kinetics of fat emulsions determined by Coulter counter measurements, Eur. J.
Pharm. Biopharm. 38, 43S, 1992
(82) Blunk, T.,
Hochstrasser, D.F., Sanchez, J.-C., Müller, B.W., Müller, R.H.,
Plasmaprotein-Adsorptionsmuster auf kolloidalen Arzneistoffträgern - eine neue
Perspektive im Drug Targeting, Arch. Pharm 326, 613,
1993
(83) Diederichs, J.E., Müller, R.H.,
Surfactant-Liposomen zur Behandlung des IRDS - Scaling
up der Herstellung, Arch. Pharm
326, 626, 1993
(84) Schuhmann, R., Müller, R.H., Koaleszenzverhalten von Emulsionen in Abhängigkeit von
Elektrolytkonzentration, Temperatur und Konzentration der dispersen
Phase, Arch. Pharm 326, 732, 1993
(85) Blunk, T.,
Hochstrasser, D.F., Sanchez, J.-C., Calvör, A., Lück,
M., Müller, B.W., Müller, R.H., Zweidimensionale Gelelektrophorese zur Untersuchung der
Plasmaproteinadsorption auf Nanopartikeln, Arch. Pharm
326, 751, 1993
(86) zur Mühlen, A., Schwarz, C., Mehnert, W., Müller, R.H.,
Produktion von "solid lipid nanoparticles"
(SLN) für die kontrollierte Arzneistoffapplikation, Arch. Pharm
326, 752, 1993
(87) Diederichs, J.E., Müller, R.H., Reifung und Mikroviskosität von Surfactant-Liposomen zur Behandlung des IRDS, Arch. Pharm 326, 755, 1993
(88) Blunk, T., Hochstrasser, D.F., Sanchez, J., Müller, B.W., Müller, R.H., Different protein adsorption patterns on i.v. drug carriers targeted to bone marrow and circulating in blood, Eur. J. Pharm. Biopharm. 40, 33S, 1994
(89) Diederichs, J.E., Müller, R.H., Large-scale production of liposomes for IRDS treatment - effect of production parameters on liposome quality, Eur. J. Pharm. Biopharm. 40, 25S, 1994
(90) Schwarz, C., Mehnert, W., Müller, R.H., Influence of production parameters of solid lipid nanoparticles (SLN) on the suitability for intravenous injection, Eur. J. Pharm. Biopharm. 40, 24S, 1994
(91) Weyhers, H., Mehnert, W., Müller, R.H., Production and characterization of surface-modified "solid lipid nanoparticles" (SLN), Eur. J. Pharm. Biopharm. 40, 15S, 1994
(92) Huber, G.M.W., Müller, R.H., Becker, R., Prediction of the flow properties of mixtures of bulk solids using a model equation based on the powder characteristics, Eur. J. Pharm. Biopharm. 40, 20S, 1994
(93) Freitas, C., Mehnert, W., Müller, R.H., Stabilization of "solid lipid nanoparticles" (SLN) by spray drying, Eur. J. Pharm. Biopharm. 40, 29S, 1994
(94) Maaßen, S., Weyhers, H., Mehnert, W., Müller, R.H., Surface-modified solid lipid nanoparticles (SLN) - in vitro affinity to human granulocytes, Eur. J. Pharm. Biopharm. 40, 41S, 1994
(95) Bucke, W.E., Hänsch, H., Ehlers, S., Müller, R.H., Production of liposomes with incorporated antimicrobials for treatment of M. avium and M. tuberculosis infections, Eur. J. Pharm. Biopharm. 40, 42S, 1994
(96) Schwarz, C., Mehnert, W., Müller, R.H., Influence of drug incorporation and lyophilisation on the physical stability of solid nanoparticles (SLN), Eur. J. Pharm. Biopharm. 40, 52S, 1994
(97) Radatz, C., Sachse, A., Rößling, G., Müller, R.H., Stabilization of iopromide-carrying liposomes by freeze drying. Influence of freezing and lyophilization conditions on the quality of the resuspended material, Eur. J. Pharm. Biopharm. 40, 53S, 1994
(98) Schuhmann, R., Müller, R.H., Determination of stabilizing and destabilizing effects in TPN-regimes, Eur. J. Pharm. Biopharm. 40, 54S, 1994
(99) Rühl, D., Maaßen, S., Schwarz, C., Mehnert,
W., Müller, R.H., Comparative cytotoxicity of solid lipid
nanoparticles (SLN), polyester and cyanoacrylate particles, Eur. J. Pharm. Biopharm. 40, 61S, 1994
(100) Schuhmann, R., Müller, R.H., Problemstellungen
und Lösungsmöglichkeiten bei der Probenaufbereitung für den Coulter counter, Coulter User-Meeting, Krefeld, 27. Januar 1994
(101) Schuhmann, R., Müller, R.H.,
Stabilitätsuntersuchungen von pharmazeutischen Produkten mit dem Coulter-Meßprinzip, Coulter User-Meeting, Krefeld, 27. Januar 1994
(102) Schuhmann, R., Müller, R.H., Stabilitätsuntersuchungen von pharmazeutischen Produkten, insbesondere von TPN-Regimen, mit dem Coulter Meßprinzip, Coulter Workshop, Bayer AG, Leverkusen, 9. Februar 1994
(103) Müller,
R.H., Drug targeting with intravenously injected
nanoparticles, 1st International Meeting on Pharmacy & Pharmaceutical
Sciences, Istanbul, 4.-7. September, 22, 1994
(104) Bucke, W.E., Hänsch, H.C.R., Ehlers, S., Diederichs, J.E., Müller, R.H., Hahn, H., Liposome-encapsulated amikacin. I. Production and characterization, Conference on Liposomes in Biomedical Research, Max-Delbrück-Centrum, Berlin, Oktober 1994
(105) Ehlers, S., Hänsch, H.C.R., Bucke, W., Müller, R.H., Hahn, H., Liposome-encapsulated amikacin. II. Therapeutic efficacy in experimental infection with Mycobacterium avium, Conference on Liposomes in Biomedical Research, Max-Delbrück-Centrum, Berlin, Oktober 1994
(106) Diederichs, J.E., Müller, R.H., Industrial Scale Production and Characterisation of Lung Surfactant Liposomes, Conference on Liposomes in Biomedical Research, Max-Delbrück-Centrum, Berlin, Oktober 1994
(107) Hänsch, H.C.R., Bucke, W., Müller, R.H., Hahn, H., Mielke, M.E.A., Ehlers, S., Mechanism of granuloma formation (GF) during experimental infection with Mycobacterium avium, 12th European Immunology Meeting, European Federation of Immunological Society, Barcelona, Abstr. no. 7, 379, June 1994
(108) Müller, R.H., Blunk, T., Lück. M., Drug targeting with intravenously injectable nanoparticles - surface modification by polymer adsorption and interaction with plasma proteins, 5th Symposium on Surface and Colloid Science - Workshop on Amphiphilic Polymers, University of Lund, 19th - 20th October 1994
(109) Müller, R.H., Blunk, T., Lück, M., Hochstrasser, D.F., Sanchez, J.-C., Müller B.W., Protein Adsorption on a Range of Surface-Modified Polystyrene Particles - Evaluation by HR Two- Dimensional Polyacrylamide Gel Electrophoresis, Eur. J. Pharm. Sci. 2, 92, 1994
(110) Schwarz, C., Mehnert, M., Müller, R.H., Lyophilization of Solid Lipid Nanoparticles (SLN), Eur. J. Pharm. Sci. 2, 177, 1994
(111) Freitas, C., Lucks, J.S., Müller, R.H., Effect of Storage Conditions on Long-Term Stability of "Solid Lipid Nanoparticles" (SLN) in Aqueous Dispersion, Eur. J. Pharm. Sci. 2, 178, 1994
(112) Schuhmann, R. Müller R.H., Physical Long Term Stability of Lipofundin Fat Emulsions for Parenteral Nutrition, Eur. J. Pharm. Sci. 2, 186, 1994
(113) Huber, G.M.W., Müller, R.H., Becker, R., Prediction of the Flow Properties of Mixtures of Bulk Solids Using Model Equations Based on the Specific Surface and the Jenike-Flow Factor, Eur. J. Pharm. Sci. 2, 190, 1994
(114) Rühl, D., Schulze-Forster, K., Maurer, H.R., Müller, R.H., Poloxamer and Poloxamine Surface-Modified Polystyrene Model Drug Carriers: Interaction with HL 60 Cells, Eur. J. Pharm. Sci. 2, 192, 1994
(115) Blunk, T., Lück, M., Hochstrasser, D.F., Sanchez, J.-C., Müller B.W., Müller, R.H., Kinetics of Protein Adsorption on Model Particles for Drug Targeting, Eur. J. Pharm. Sci. 2, 192, 1994
(116) Bucke, W.E., Hänsch, H.C.R., Ehlers, S., Diederichs, J.E., Müller, R.H., Hahn, H., Amikacin-Loaded Liposomes - Production, Characterization and Treatment Efficiency in Mycobacterium Avium Intracellulare Complex (MAC) Infected Mice, Eur. J. Pharm. Sci. 2, 176, 1994
(117) Weyhers, H., Lück, M., Mehnert, W., Müller, R.H., Solid Lipid Nanoparticles (SLN) for Controlled Delivery of Hydrophilic Drugs, 2nd International Conference on Biotechnology, Ghent, Belgium, April 1995
(118) Lück, M., Blunk, T., Paulke B.-R., Müller, R.H., Plasma Protein Adsorption Patterns on Latex Particles with Different Surface Groups - Evaluation by Two-Dimensional Polyacrylamide Gel Electrophoresis, 2nd International Conference on Biotechnology, Ghent, Belgium, April 1995
(119) Weyhers, H., Ehlers. S., Mehnert, W., Hahn, H., Müller, R.H., In Vivo Toxicity of Cetylpalmitate and Compritol ATO 88 SLN, Poster presentation at the 1st Expert Meeting on Colloidal Drug Carriers, Berlin, 15.-17. Juni 1995, Poster Nr.: 2
(120) Haltner, E., Weyhers, H., Mehnert, W., Müller, R.H., Lehr, C.M., Interactions of SLN with Caco-2 cell-monolayers, Poster presentation at the 1st Expert Meeting on Colloidal Drug Carriers, Berlin, 15.-17. Juni 1995, Poster Nr.: 3
(121) Freitas, C., Lucks, J.S., Müller, R.H., Investigation of Long-Term Stability of SLN in Aqueous Dispersion, Poster presentation at the 1st Expert Meeting on Colloidal Drug Carriers, Berlin, 15.-17. Juni 1995, Poster Nr.: 6
(122) Blunk, T., Lück, M., Müller B.W., Müller, R.H., Interaction between Plasma Proteins and Nanoparticles Coated with Poloxamer 235, 238 and 407, Poster presentation at the 1st Expert Meeting on Colloidal Drug Carriers, Berlin, 15.-17. Juni 1995, Poster Nr.: 20
(123) Blunk, T., Lück, M., Paulke, B.-R., Müller, R.H., Interaction of particles with plasma proteins I.: Kinetics of Adsorption, Poster presentation at the 1st Expert Meeting on Colloidal Drug Carriers, Berlin, 15.-17. Juni 1995, Poster Nr.: 21
(124) Lück, M., Blunk, T., Paulke, B.-R., Müller, R.H., Interaction of particles with plasma proteins II.: Effect of Different Surface Characteristics, Poster presentation at the 1st Expert Meeting on Colloidal Drug Carriers, Berlin, 15.-17. Juni 1995, Poster Nr.: 22
(125) Thode, K., Kresse, M., Pfefferer, D., Semmler, W., Müller, R.H., Determination of the Adsorption Pattern of Plasma Proteins on Magnetites for Magnetic Resonance Imaging (MRI), Poster presentation at the 1st Expert Meeting on Colloidal Drug Carriers, Berlin, 15.-17. Juni 1995, Poster Nr.: 23
(126) Bucke, W.E., Hänsch, H.C.R., Ehlers, S., Diederichs, J.E, Hahn, H., Müller, R.H., Production of Amikacin-Loaded Liposomes for Treatment of M. avium Infections, Poster presentation at the 1st Expert Meeting on Colloidal Drug Carriers, Berlin, 15.-17. Juni 1995, Poster Nr.: 24
(127) Ehlers, S., Hänsch, H.C.R., Bucke, W.E., Müller, R.H., Hahn, H., Liposome-Encapsulated Amikacin: Therapeutic Efficacy in Experimental Infection with Mycobacterium avium, Poster presentation at the 1st Expert Meeting on Colloidal Drug Carriers, Berlin, 15.-17. Juni 1995, Poster Nr.: 25
(128) Leitzke, S., Ehlers, S., Borner, K., Bucke, W.E., Müller, R.H., Hahn, H., Liposomal Amikacin for Treatment of Disseminated M. avium Infection: Rationale and Efficacy of Prolonged Interval Application, Poster presentation at the 1st Expert Meeting on Colloidal Drug Carriers, Berlin, 15.-17. Juni 1995, Poster Nr.: 26
(129) Peters, K., Becker, R., Kruss, B., Müller, R.H., Nanosuspensions of Drugs as i.v. Delivery System, Poster presentation at the 1st Expert Meeting on Colloidal Drug Carriers, Berlin, 15.-17. Juni 1995, Poster Nr.: 29
(130) Diederichs, J.E., Eckstein, B., Müller, R.H., Differences in the Stability of Emulsions Versus the Addition of the Divalent Ions Ca and Mg, Poster presentation at the 1st Expert Meeting on Colloidal Drug Carriers, Berlin, 15.-17. Juni 1995, Poster Nr.: 40
(131) Thode, K., Kresse, M., Pfefferer, D., Semmler, W., Müller, R.H., Determination of the Surface Hydrophobicity of Magnetite Dispersions, Poster presentation at the 1st Expert Meeting on Colloidal Drug Carriers, Berlin, 15.-17. Juni 1995, Poster Nr.: 43
(132) Rühl, D., Paulke, B.-R., Maurer, H.R., Müller, R.H., Investigations of the Phagocytosis of Polymeric Particles by HL60-Cells as a Function of Surface Hydrophobicity and Fluorescent Labelling, Poster presentation at the 1st Expert Meeting on Colloidal Drug Carriers, Berlin, 15.-17. Juni 1995, Poster Nr.: 45
(133) Lück, M., Blunk, T., Paulke, B.-R.,
Sanchez, J.-C., Hochstrasser, D.F., Müller, R.H., Plasma Protein
Adsorption on Polystyrene Particles as a Function of their Size - Evaluation by
Two-Dimensional Polyacrylamide Gel Electrophoresis (2-D PAGE), Electrophoresis
’95, Paris, 30. August - 2. September, 1995
(134) Bucke, W.E.,
Ehlers, S., Leitzke, S., Borner, K., Diederichs,
J.E., Hahn, H., Müller, R.H., Kontrollierte Optimierung von liposomalem Amikacin und therapeutische Auswirkung der Produktqualität
bei Mykobakterien-Infektion, Jahrestagung der Deutschen Pharmazeutischen
Gesellschaft, Jena, DV 19, S. 51, 20.-24. September 1995
(135) Kresse, M., Pfefferer,
D., Thode, K., Müller, R.H., Semmler, W., Anwendung
der Gelfiltrationschromatographie (GFC) zur Bestimmung der Größe von
Dextran-stabilisierten Eisenoxidpartikeln, Jahrestagung der Deutschen
Pharmazeutischen Gesellschaft, Jena, PV3, S. 112, 20.-24. September 1995
(136) Freitas, C., Lucks, J.S., Müller,
R.H., Sprühtrocknung von „Solid Lipid Nanoparticles“
(SLN) - Optimierte Rezepturen, Jahrestagung der Deutschen Pharmazeutischen
Gesellschaft, Jena, PV36, S. 155, 20.-24. September 1995
(137) Lück, M., Blunk,
T., Paulke, B.-R., Müller, R.H., Analytik der Plasmaproteinadsorption
auf Nanopartikeln mit unterschiedlichen Oberflächeneigenschaften mittels 2-D
PAGE, Jahrestagung der Deutschen Pharmazeutischen Gesellschaft, Jena, PV37, S.
156, 20.-24. September 1995
(138) Peters, K., Müller,R.H.,
Nanosuspensionen für die intravenöse Applikation schwerlöslicher
Arzneistoffe, Jahrestagung der Deutschen Pharmazeutischen Gesellschaft, Jena,
PV38, S. 157, 20.-24. September 1995
(139) Rühl, D., Paulke, B.-R., Maurer, H.R.,
Müller, R.H., Einfluß der
Oberflächenhydrophobie und der Fluoreszenzmarkierung von Polystyrol-Partikeln
auf die in vitro-Phagozytose von HL60-Zellen, Jahrestagung der Deutschen
Pharmazeutischen Gesellschaft, Jena, PV39, S. 158, 20.-24. September 1995
(140) Thode, K.,
Kresse, M., Pfefferer, D., Semmler, W., Müller, R.H.,
Bestimmung der Oberflächenhydrophobie von superparamagnetischen
Eisenoxidpartikeln durch Mini-HIC, Jahrestagung der Deutschen Pharmazeutischen
Gesellschaft, Jena, PV40, S. 159, 20.-24. September 1995
(141) Weyhers, H., Lück,
M., Mehnert, W., Müller, R.H., Feste Lipid Nanopartikel - Inkorporierung von
hydrophilen Arzneistoffen, Jahrestagung der Deutschen Pharmazeutischen
Gesellschaft, Jena, PV42, S. 161, 20.-24. September 1995
(142) Müller, R.H., Thode, K., Einsatzmöglichkeiten von PCS-Mehrwinkelanalyse und Laserdiffraktometrie anhand pharmazeutischer Beispiele, Coulter User-Meeting, Partikelmeßtechnik, Krefeld, 21.-22. November 1995
(143) Schlichter, N., Maier, F.K., Müller, R.H., Krause, W., Dendritic Contrast Agents: Characterization and Stability after Autoclaving, Eur. J. Pharm. Biopharm. 42, 30S, 1996
(144) Pinto, J.F., Müller, R.H., Influence of Five Selected Factors on Size, Zetapotential and Stability of ‘Solid Lipid Nanoparticles’ (SLN) Dispersions Prepared According to a Full Factorial Design (25) , Eur. J. Pharm. Biopharm. 42, 40S, 1996
(145) Pinto,
J.F., Müller, R.H., Pellets as Carriers of ‘Solid Lipid Nanoparticles’
(SLN) for Oral Administration of Drugs, Eur. J. Pharm. Biopharm.
42, 35S, 1996
(146) Weyhers, H., Mehnert, W., Kreuter, J., Müller, R.H., Radiolabelling of Solid Lipid Nanoparticles (SLN), Eur. J. Pharm. Biopharm. 42, 42S, 1996
(147) Rühl, D., Lück, M., Paulke, B.-R., Müller, R.H., Hydrophobicity, phagocytic uptake and plasma protein adsorption of fluorescent polymeric nanoparticles, Eur. J. Pharm. Biopharm. 42, 41S, 1996
(148) Runge, S., zur Mühlen, A., Mehnert, W., Müller, R.H., SLN Production with Surfactants Suitable for I.V. Administration - Effect of Production Parameters, Eur. J. Pharm. Biopharm. 42, 41S, 1996
(149) Bensouda, Y., Runge, S., Müller, R.H., Chemical and Physical Influences of Solid Lipid Nanoparticles (SLN) Components on their Freeze-Drying, Eur. J. Pharm. Biopharm. 42, 36S, 1996
(150) Almeida, A.J., Runge, S., Müller, R.H., Production and Characteristics of Peptide-Loaded Solid Lipid Nanoparticles (SLN), Eur. J. Pharm. Biopharm. 42, 44S, 1996
(151) Lück, M., Paulke, B.-R., Müller, R.H., Plasma Protein Adsorption Patterns on Model Particles with Different Surface Properties, Eur. J. Pharm. Biopharm. 42, 34S, 1996
(152) Lück, M., Blunk, T., Paulke, B.-R., Müller, R.H., Analysis of Plasma Protein Adsorption on Polystyrene Particles of Different Size, Eur. J. Pharm. Biopharm. 42, 39S, 1996
(153) Thode, K., Lück, M., Kresse, M., Pfefferer, D., Semmler, W., Müller, R.H., A Comparison of Two Separation Methods to Prepare Magnetites for the Analysis of Protein Adsorption, Eur. J. Pharm. Biopharm. 42, 42S, 1996
(154) Freitas, C., Müller, R.H., Solid Lipid Nanoparticles (SLN) - Improvement of long-term stability, Eur. J. Pharm. Biopharm. 42, 33S, 1996
(155) Peters, K., Müller, R.H., Nanosuspension - Solution for the formulation of poorly soluble drugs, Eur. J. Pharm. Biopharm. 42, 35S, 1996
(156) Müller,
R.H., Freitas, C., zur Mühlen,
A., Mehnert, W., Long-term
stability investigations of Solid Lipid Nanoparticles (SLN), Eur. J. Pharm.
Sci., 4, S132, 1996
(157) Müller, R.H., Freitas, C., zur Mühlen, A., Mehnert, W., Solid Lipid Nanoparticles (SLN) for controlled drug delivery, Eur. J. Pharm. Sci., 4, S75, 1996
(158) Hedeman, H., Lück, M., Frokjaer, S., Müller, R.H., In vitro interaction of fat emulsions based on structured lipids with plasma proteins, Eur. J. Pharm. Sci., 4, S139, 1996
(159) Peters, K., Müller, R.H., Electron microscopy studies of nanosuspensions of poorly soluble drugs, Eur. J. Pharm. Sci., 4, S158, 1996
(160) Thode, K., Lück, M., Kresse, M., Pfefferer, D., Semmler, W., Müller, R.H., Two-dimensional polyacrylamide gel electrophoresis (2-D PAGE) for determination of plasma protein adsorption patterns on iron oxide particles, Eur. J. Pharm. Sci., 4, S154, 1996
(161) Thode, K., Kresse, M., Pfefferer, D., Semmler, W., Müller, R.H., Surface characterization and in vivo distribution of iron oxide particles, Eur. J. Pharm. Sci., 4, S154, 1996
(162) Peters, K., Müller, R.H., Nanosuspensions as oral and parenteral formulations for poorly soluble drugs, Eur. J. Pharm. Sci., 4, S44, 1996
(163) Runge, S., Mehnert, W., Müller, R.H., SLN (Solid Lipid Nanoparticles), a novel formulation for the oral administration of drugs, Eur. J. Pharm. Sci., 4, S132, 1996
(164) Dingler, A., Runge, S., Müller, R.H., SLN (Solid Lipid Nanoparticles) as drug carrier for an i.v. administration of poorly water soluble drugs, Eur. J. Pharm. Sci., 4, S132, 1996
(165) Diederichs, J.E., Dressler, C., Bucke, W., Daskalaki, A., Philipp, C., Müller, R.H., Berlien, H.-P., Methylene-Blue Liposomes - A novel approach in photodynamic therapy of fibrosarcoma cells, Eur. J. Pharm. Sci. 4, S137, 1996
(166) Dingler, A., Krohs, S., Lukowski, G., Gohla, S., Müller, R.H., SLN (Solid Lipid Nanoparticles) as new solid carrier of active ingredients in cosmetics, Eur. J. Pharm. Sci. 4, S148, 1996
(167) Müller, R.H., Intravenously injected particles: surface properties and interaction with blood proteins – the key determining the organ distribution, First International Workshop on the Clinical Application of Magnetic Carriers, Rostock, 5.-7.9.1996
(168) Lück, M., Thode, K., Paulke B.-R., Müller, R.H., Influence of surface characteristics on the plasma protein adsorption onto nanoparticles - Evaluation by two dimensional polyacrylamid gel electrophoresis, First International Workshop on the Clinical Application of Magnetic Carriers, Rostock, 5.-7.9.1996
(169) Thode, K., Lück, M., Kresse, M., Semmler, W., Müller, R.H., Determination of the plasma protein adsorption onto iron oxide particles, First International Workshop on the Clinical Application of Magnetic Carriers, Rostock, 5.-7.9.1996
(170) Lück, M., Harnisch, S., Blunk, T., Paulke, B.-R., Schröder, W., Müller, R.H., Analysis of plasma protein adsorption on colloidal drug carriers - Identification of proteins enriched on the surface, Forum Deutsche Elektrophorese Gesellschaft, München, 23.-25.10.1996
(171) Thode, K., Lück, M., Schröder, W., Kresse, M., Semmler, W., Müller, R.H., The Influence of the sample preparation on plasma protein adsorption on macromolecule stabilized iron oxide particles, Forum Deutsche Elektrophorese Gesellschaft, München, 23.-25.10.1996
(172) Zimmer, A., Rühl, D., Müller, R.H., Atmaca-Abdel-Azis, S., Noe, C.R., Cell uptake and toxicity of antisense-oligonucleotide-loaded cationic liposomes, Pharm. Res., 13 (9), S-386, 1996
(173) Almeida, A.J., Dingler, A., Runge, S., Müller, R.H., Nanopartículas de lipidos sólidos: Sistema coloidal alternativo para veiculação e libertação controlada de fármacos, Proceedings of the I Congresso Nacional de Farmacêuticos/III Congresso Munidial de Farmacêuticos de Linua Portuguesa, Lisbon, 109, 22.-24. November 1996
(174) Almeida, A.J., Runge, S., Müller, R.H., Estudos de encapsulação de fármacos de natureza peptídica em nanopartículas de lipidos sólidos, Proceedings of the I Congresso Nacional de Farmacêuticos/III Congresso Munidial de Farmacêuticos de Linua Portuguesa, Lisbon, 112, 22.-24. November 1996
(175) Pinto,
J.F., Müller, R.H., Influência de cinco factores pré-seleçcionados sobre o tamanho potencial zeta e estabilidade de nanopartículas lipídicas sólidas em dispersões aquosas
preparadas de acordo com uma concepção experimental
factorial (25), Proceedings of the I Congresso
Nacional de Farmacêuticos/III Congresso
Munidial de Farmacêuticos
de Linua Portuguesa, Lisbon, 22.-24. November 1996
(176) Gref, R., Quellec, P., Dellacharie, E., Lück, M., Müller, R.H., Influence des
agents tensioactifs résiduels sur la charge de surface des nanosphères,
leur phagocytose et leur interaction avec les protéines plasmatiques, Groupe thematique de recherche sur les vecteurs, Paris, 1996
(177) Harnisch, S., Blunk, T., Müller, R.H., The Kinetics of
Plasma Protein Adsorption on Oil-in-Water Emulsions, Electrophorese Forum 1997,
Strassburg, 25.-27. November 1997, Poster Nr.: 59
(178) Müller, R.H., Dobrucki, R., Radomska, A.,
Stale lipofilowe nanoczastki
jako nowe nosniki leku, Konferencja
z okazji 50-lecia Polskiego
Towarzystwa Farmaceutycznego,
Poznán, 80, 1997
(179) Kresse, M., Thode, K., Müller, R.H., Semmler, W., 2-Dimensional polyacrylamide electrophoresis (2-D PAGE) to investigate opsonization of SPIO in vitro, 6th Scientific Meeting of the International Society for Magnetic Resonance in Medicine, Sydney, 18-24 April 1998
(180) Müller, R.H., Dingler,
A., Feste Lipid-Nanopartikel als kutane Wirkstoffträger: Vitamin E als
Beispiel, Abstract Book Annual Meeting of
"Gesellschaft für Dermopharmazie",
Wiesbaden, 6 May 1998
(181) Borner, K., Hartwig, H., Leitzke, S., Hahn, H., Müller, R.H., Ehlers, S., Determination of Clofazimine Nanosuspensions in Tissues and Serum by HPLC, 2nd European Congress of Chemotherapy and 7th Biannial Conference on Antiinfective Agents and Chemotherapy, Hamburg, 10-13 May 1998
(182) Müller, R.H., Dingler, A., Development of Pharmaceutical and Cosmetic Products on the basis of Solid Lipid Nanoparticles (SLN™) technology, Abstract book of the 38th Symposium of the Associazione Farmaceutica dell´Industria (AFI), Montecatini Terme, Italy, 66, 3-5 June 1998
(183) Müller, R.H, Böhm, B.H.L., Hildebrand, G.E., Nanosuspensions of poorly soluble cytotoxics: design of a lab scale production unit, 4th European Congress of Pharmaceutical Sciences, Milan, 11-13 September 1998
(184) Müller, R.H., Dingler, A., Hildebrand, G.E., The next generation after the Liposomes: LipopearlsTM/SLNTM in tropical products, 4th European Congress of Pharmaceutical Sciences, Milan, 11-13 September 1998
(185) Kayser, O., Kiderlen, A. F., Olbrich, C., Müller, R. H., Nanosuspensions and Solid Lipid Nanoparticles (SLN) as new drug carriers for targeting intracellular parasites, Symposium „Drug Against Parasites Diseases“, Montpellier, 24-26 May 1999
(186) Olbrich, C., Kayser, O., Müller, R. H., Solid Lipid Nanoparticles (SLN) – Preparation, phyagocytic uptake, in vitro cytotoxity and in vitro biodegradation of a new drug carrier for targeting intracellular parasites, Montpellier, 24-26 May 1999
(187) Paulke, B., Lieske, A., Lück, M., Geßner, A., Müller, R. H., Model Latex Particles for Mechanistic Drug Targeting Studies, 27. Hauptjahrestagung der Gesellschaft Deutscher Chemiker (37th IUPAC Congress), Berlin, 14.-19. August 1999