Publication list Prof. R. H. Müller

(Total Publications: 1083)

Patents/Patent applications: 21 (not listed)

Books: 18

Book chapters: 62

Refereed papers: 260

Non-refereed papers: 55

Proceedings: 273

Abstracts: 394

Books:

(1) Müller, R. H., Colloidal Carriers for Controlled Drug Delivery and Targeting - Modification, Characterization and in vivo Distribution, Wissenschaftliche Verlagsgesellschaft Stuttgart, CRC Press Boca Raton, 379 S., 1991

(2) Müller, R. H., Zetapotential und Partikelladung - Kurze Theorie, praktische Meßdurchführung, Dateninterpretation, Wissenschaftliche Verlagsgesellschaft Stuttgart, 254 S.,1996

(3) Müller, R. H., Schuhmann, R., Teilchengrößenmessung in der Laborpraxis, Wissenschaftliche Verlagsgesellschaft Stuttgart, 191 S., 1996

(4) Müller, R. H., Hildebrand, G. E. (Hrsg), Pharmazeutische Technologie: Moderne Arzneiformen, Lehrbuch für Studierende der Pharmazie - Nachschlagewerk für Apotheker in Offizin, Krankenhaus und Forschung, Wissenschaftliche Verlagsgesellschaft Stuttgart, 1. Aufl., 348 S., 1997

(5) Müller, R. H., Mehnert, W. (Hrsg), Particle and Surface Characterisation Methods, Wissenschaftliche Verlagsgesellschaft Stuttgart, 280 S., 1997

(6) Müller, R. H., Hildebrand, G. E. (Hrsg), Pharmazeutische Technologie: Moderne Arzneiformen, Lehrbuch für Studierende der Pharmazie - Nachschlagewerk für Apotheker in Offizin, Krankenhaus und Forschung, Wissenschaftliche Verlagsgesellschaft Stuttgart, 2. erweiterte Aufl., 471 S., 1998

(7) Diederichs, J. E., Müller, R. H. (Hrsg), Future Strategies for Drug Delivery with Particulate Systems, Wissenschaftliche Verlagsgesellschaft Stuttgart, 194 S., 1998

(8) Müller, R. H., Hildebrand, G. E., Jachowicz, R., Kubis, A., Klawe, J. (Hrsg), Technologia nowoczesnych postaci leków, Wydawnictwo Lekarskie PZWL Warschau, 356 S., 1998

(9) Müller, R. H., Benita, S., Böhm, B. (Hrsg), Emulsions and Nanosuspensions for the Formulation of Poorly Soluble Drugs, medpharm Scientific Publishers Stuttgart, 396 S., 1998

(10) Müller, R. H., Schneppe, T., Qualitätsmanagement und Validierung in der pharmazeutischen Praxis, Editio Cantor Verlag Aulendorf, 182 S., 1999

(11) Zabka, M., Müller, R. H., Hildebrand, G. E. (Hrsg), Moderné lieky vo farmaceutickej technológii, slovakische Übersetzung des Lehrbuchs „Pharmazeutische Technologie: Moderne Arzneiformen“, Slovak Academic Press Bratislava, 487 S., 1999

(12) Kayser, O., Müller, R. H. (Hrsg), Pharmazeutische Biotechnologie. Ein Kompendium für Forschung und Praxis, Wissenschaftliche Verlagsgesellschaft, Stuttgart, 2000

(13) Zabka, M., Müller, R. H., Hildebrand, G. E. (Hrsg), Moderní lékové formy ve farmaceutické technologii, tschechische Übersetzung des Lehrbuchs „Pharmazeutische Technologie: Moderne Arzneiformen“, Slovak Academic Press Bratislava, 486 S., 2001

(14) Müller, R. H., Böhm, B. (Hrsg), Dispersion Techniques for Laboratory and Industrial Scale Processing, Wissenschaftliche Verlagsgesellschaft Stuttgart, 113 S., 2001

(15) Müller, R. H., Schneppe, T., Qualitätsmanagement und Validierung in der pharmazeutischen Praxis, Editio Cantor Verlag Aulendorf, 2. erweiterte Aufl., 218 S., 2003

(16) Kayser, O., Müller, R. H. (Hrsg), Biotechnologia Farmaceutiyczna, polnische Übersetzung des Buches „Pharmazeutische Biotechnologie. Ein Kompendium für Forschung und Praxis“, Wydawnictwo Lekarskie PZWL Warschau, 415 S., 2003

(17) Kayser, O., Müller, R. H. (Hrsg), Pharmaceutical Biotechnology. Drug Discovery and Clinical Applications, Wiley-VCH, Weinheim, 311 S., 2004

(18) Müller, R. H., Hildebrand, G. E. (Hrsg), chinesische Übersetzung des Lehrbuches: Pharmazeutische Technologie: Moderne Arzneiformen, Lehrbuch für Studierende der Pharmazie - Nachschlagewerk für Apotheker in Offizin, Krankenhaus und Forschung, 2. erweiterte Aufl., People’s Military Medical Press, 341 S., 2004

Book chapters:

(1) Müller, R. H., Polydispersität, elektrophoretische Beweglichkeit hochdisperser Systeme, PhD thesis, University of Kiel, Germany, 1983

(2) Davis, S. S., Douglas, S., Illum, L., Jones. P. D. E., Mak, E., Müller, R. H., "Targeting of Colloidal Carriers and the Role of Surface Properties", in: Targeting of Drugs with Synthetic Systems (Gregoriadis, G., Senior, J. und Poste, G., eds.) Plenum, 123, 1986

(3) Müller, R. H., Davis, S. S., Illum, L., Mak, E., "Particle Charge and Surface Hydrophobicity of Colloidal Drug Carriers", in: Targeting of Drugs with Synthetic Systems (Gregoriadis, G., Senior, J. und Poste, G., eds.) Plenum, 239 ,1986

(4) Müller, R. H., Heinemann, S., Surface Modelling of Microparticles as Parenteral Systems with High Tissue Affinity, in: Bioadhesion - Possibilities and Future Trends (Gurny, R. and Junginger, H. E., eds.), Wissenschaftliche Verlagsgesellschaft Stuttgart, 202-214, 1989

(5) Müller, R. H., Davis, S. S., Mak, E., "Surface Characterization of Colloidal Drug Carriers for Drug Targeting by Aqueous Two Phase Partitioning", in: Separation using Aqueous Phase Systems: Applications in Cell Biology and Biotechnology (Fisher, D. und Sutherland, I. A.,eds.) Plenum New York, 149-155, 1989

(6) Müller, R. H., Heinemann, S., Blunk, T., Rudt, S., "PCS and zeta potential characterization of model drug carriers - essential information for the interpretation of in vitro and in vivo data", in: Laser Light Scattering in Biochemistry (Sattelle, D. B. and Harding, S., eds.), Redwood Press Ltd., Melksham, Wiltshire, 425-440, 1992

(7) Müller, R. H., Feste Lipidnanopartikel (SLN), in: Pharmazeutische Technologie: Moderne Arzneiformen (Müller, R. H., Hildebrand, G. E. Hrsg.), Wissenschaftliche Verlagsgesellschaft Stuttgart, 265-272, 1997

(8) Müller, R. H., „Nanosuspensionen - eine neue Formulierung für schwerlösliche Arzneistoffe“, in: Pharmazeutische Technologie: Moderne Arzneiformen (Müller, R. H., Hildebrand, G. E., Hrsg.), Wissenschaftliche Verlagsgesellschaft Stuttgart, 273-278, 1997

(9) Müller, R. H., „Surface Hydrophobicity - Determination by ROSE Bengal (RB) Adsorption Methods“, in: Particle and Surface Characterisation Methods (Müller, R. H., Mehnert, W., Hrsg), Wissenschaftliche Verlagsgesellschaft Stuttgart, 215-228, 1997

(10) Thode, K., Müller, R. H., „Theory and Set Up of Hydrophobic Interaction Cromatography (HIC)“, in: Particle and Surface Characterisation Methods (Müller, R. H., Mehnert, W., Hrsg), Wissenschaftliche Verlagsgesellschaft Stuttgart, 229-234, 1997

(11) Müller, R. H., „HIC for the Determination of Surface Hydrophobicity of Particulates“, in: Particle and Surface Characterisation Methods (Müller, R. H., Mehnert, W., Hrsg), Wissenschaftliche Verlagsgesellschaft Stuttgart, 235-249, 1997

(12) Thode, K., Kresse, M., Müller, R. H., „HIC of Iron Oxide Dispersions Stabilized by Different Macromolecules“, in: Particle and Surface Characterisation Methods (Müller, R. H., Mehnert, W., Hrsg), Wissenschaftliche Verlagsgesellschaft Stuttgart, 251-259, 1997

(13) Müller, R. H., Lück, M., Harnisch, S., Thode, K., „Intravenously Injected Particles; Surface Properties and Interaction with Blood Proteins - the Key Determining the Organ Distribution“, in: Scientific and Clinical Applications of Magnetic Carriers (Schütt, W., Teller, J., Häfeli, U., Zborowski, M., eds.), 135-148, 1997

(14) Müller, R. H., Solid Lipid Nanoparticles, nanosuspensions and liposomes for pharmaceutical and cosmetic applications, in: Future Strategies for Drug Delivery with Particulate Systems (Diederichs, J.E. and Müller, R.H., eds.), CRC Press Boca Raton, 71-72, 1998

(15) Müller, R. H., Particulate systems for the controlled delivery of active compounds in pharmaceutics and cosmetics, in: Future Strategies for Drug Delivery with Particulate Systems (Diederichs, J.E. and Müller, R.H., eds.), CRC Press Boca Raton, 73-90, 1998

(16) Runge, S. A., Müller, R. H., Solid lipid nanoparticles (SLN™) for oral administration - drug incorporation and degradation, in: Future Strategies for Drug Delivery with Particulate Systems (Diederichs, J.E. and Müller, R.H., eds.), CRC Press Boca Raton, 91-100, 1998

(17) Peters, K., Müller, R. H., Nanosuspensions - a novel formulation of poorly soluble drugs, in: Future Strategies for Drug Delivery with Particulate Systems (Diederichs, J.E. and Müller, R.H., eds.), CRC Press Boca Raton, 101-108, 1998

(18) Lück, M., Paulke, B.-P., Schröder, W., Müller, R. H.,Two-dimensional electrophoresis (2-DE) for the determination of plasma proteins adsorbed on model drug carriers, in: Future Strategies for Drug Delivery with Particulate Systems (Diederichs, J. E. and Müller, R. H., eds.), CRC Press Boca Raton, 109-117, 1998

(19) Herbort, J., Diederichs, J. E., Müller, R. H., Development of a liposomal formulation for hair care use, in: Future Strategies for Drug Delivery with Particulate Systems (Diederichs, J. E. and Müller, R. H., eds.), CRC Press Boca Raton, 118-126, 1998

(20) Müller, R H., Runge, S. A. „Solid Lipid Nanoparticles (SLN^Ò) for controlled drug delivery“, in: Submicron Emulsions in Drug Targeting and Delivery (Benita, S., ed.), 219-234, 1998

(21) Müller, R. H., Böhm, B. H. L., Nanosuspensions, in: Emulsions and Nanosuspensions for the Formulation of Poorly Soluble Drugs (Müller, R. H., Benita, S., Böhm, B. H. L., eds.), medpharm Scientific Publishers Stuttgart, 149-174, 1998

(22) Müller, R. H., Feste Lipidnanopartikel (SLN), in: Pharmazeutische Technologie: Moderne Arzneiformen (Müller, R. H., Hildebrand, G. E. Hrsg.), 2. Auflage, Wissenschaftliche Verlagsgesellschaft Stuttgart, 357-366, 1998

(23) Müller, R. H., Alkoholische Pflanzenextrakte, in: Pharmazeutische Technologie: Moderne Arzneiformen (Müller, R. H., Hildebrand, G. E. Hrsg.), 2. Auflage, Wissenschaftliche Verlagsgesellschaft Stuttgart, 119-120, 1998

(24) Müller, R. H., „Nanosuspensionen - eine neue Formulierung für schwerlösliche Arzneistoffe“, in: Pharmazeutische Technologie: Moderne Arzneiformen (Müller, R. H., Hildebrand, G. E., Hrsg.), 2. Auflage, Wissenschaftliche Verlagsgesellschaft Stuttgart, 393-400, 1998

(25) Müller, R. H., Nanorozproszenia jako nowe postacie leku dla trudno rozpuszczalnych substancji leczniczych, in: Kubis, A., Jachowicz, R., Müller, R. H., Hildebrand, G. E., Technologia nowoczesnych postaci leków, Wydawnictwo Lekarskie PZWL, Warschau, 300-306, 1998

(26) Gref, R., Quellec, P., Alonso, M. J., Tobio, M., Lück, M., Müller, R. H., Dellacherie, E., PEG-Coated Nanospheres: Surface Optimization and Therapeutic Applications, in: Targeting of Drugs: Strategies for Stealth Therapeutic Systems, (Gregoriadis, G., ed.), Kluwer Academic Pub, 275-286, 1998

(27) Müller, R. H., Alkoholové rastliniié extrakty, in: Zabka, M., Müller, R. H., Hildebrand, G. E., Moderné lieky vo farmaceutickej technológii, slovakische Übersetzung des Lehrbuchs „Pharmazeutische Technologie: Moderne Arzneiformen“, 119-120, 1999

(28) Müller, R. H., Tuhé lipidové nanocastice (SLN), in: Zabka, M., Müller, R. H., Hildebrand, G. E., Moderné lieky vo farmaceutickej technológii, slovakische Übersetzung des Lehrbuchs „Pharmazeutische Technologie: Moderne Arzneiformen“, 373-382, 1999

(29) Müller, R. H., Nanosuspenzie – nová formulácia pre t’azko rozpustné liecivá, in: Zabka, M., Müller, R. H., Hildebrand, G. E., Moderné lieky vo farmaceutickej technológii, slovakische Übersetzung des Lehrbuchs „Pharmazeutische Technologie: Moderne Arzneiformen“, 409-416, 1999

(30) Müller, R. H., Jacobs, C., Kayser, O., Nanosuspensions for the Formulation of Poorly Soluble Drugs, in: Pharmaceutical Emulsions and Suspensions (Nielloud, F. and Marti-Mestres, G., eds.), Marcel Dekker, 383-407, 2000

(31) Müller, R. H., Olbrich, C., Neue Adjuvantien in der Impfstofftechnologie, in: Pharmazeutische Biotechnologie (Kayser, O., Müller, R. H., eds.), Wissenschaftliche Verlagsgesellschaft, 283-302, 2000

(32) Müller, R. H., Böhm, B. H. L., Grau, M. J., Nanosuspensions - a formulation approach for poorly soluble and poorly bioavailable drugs, in: Handbook of Pharmaceutical Controlled Release Technology (Wise, D., ed.), 345-357, 2000

(33) Müller, R. H., Dingler, A., Schneppe, T., Gohla, S., Large scale production of solid lipid nanoparticles (SLN^TM) and nanosuspensions (DissoCubes^TM), in: Handbook of Pharmaceutical Controlled Release Technology (Wise, D., ed.), 359-376, 2000

(34) Müller, R. H., Lippacher, A., Gohla, S., Solid Lipid Nanoparticles (SLN^â) as Carrier System for the Controlled Release of Drugs, in: Handbook of Pharmaceutical Controlled Release Technology (Wise, D., ed.), 377-391, 2000

(35) Müller, R. H., Wissing, S. A., Solid lipid nanoparticles (SLN^®, Lipopearls^®) for controlled delivery of active compounds, STP Pharma Sciences, Minutes Book

(36) Müller, R. H., Karsubke, G., Lemke, A., Nanosuspension system for oral delivery of poorly soluble drugs, 11^th Conference book of DMV Symposion on solid dosage formulation, DMV Japan, 26-25, 2002

(37) Müller, R. H., Radtke, M., Wissing, S., Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations, in: Human Skin, the Medium of Touch, Bulletin Technique Gattefossé 2002, 131-152, 2002

(38) Müller, R. H., Wissing, S. A., SLN and Lipopearls for topical delivery of active compounds and contolled release, in: Modified-Release Drug Delivery Systems (Rathbone, M. J., Hadgraft, J., Roberts, M. S., eds.), Marcel Dekker, 571-587, 2003

(39) Müller, R. H., Jacobs, C., Kayser, O., DissoCubes – a novel formulation for poorly soluble and poorly bioavailable drugs, in: Modified-Release Drug Delivery Systems (Rathbone, M. J., Hadgraft, J., Roberts, M. S., eds.), Marcel Dekker, 135-149, 2003

(40) Müller, R. H., Lipid-Nanopartikel (SLN, NLC) zur Verkapselung von kosmetischen Wirkstoffen, in: Kosmetikjahrbuch 2003, Global Ingredient & Formulation Guide, Verlag für chemische Industrie, Augsburg, 481-484, 2003

(41) Müller, R. H., Akkar, A., Drug nanocrystals of poorly soluble drugs, in: Encyclopedia of Nanoscience and Nanotechnology (H. S. Nalwa, ed.), American Scientific Publishers, 627-638, 2004

(42) Müller, R. H., Radtke, M., Wissing, S. A., Solid Lipid Nanoparticles and Nanostructured Lipid Carriers, in: Encyclopedia of Nanoscience and Nanotechnology (H. S. Nalwa, ed.), American Scientific Publishers, 43-56, 2004

(43) Wissing, S., Müller, R. H., Cosmetic applications of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), in: Textbook of Cosmetic Dermatology, 3rd Edition (Baran, R., Mailbach, H. I., eds.), Taylor & Francis, 71-76, 2004

(44) Kayser, O., Müller, R. H., A primer on Pharmaceutical Biotechnology and industrial applications, in: Pharmaceutical Biotechnology (O. Kayser, R. H. Müller, eds.), Wiley-VCH, 3-8, 2004

(45) Olbrich, C., Tabatt, K., Wissing, S. A., Schöler, N., Müller, R. H., Solid Lipid Nanoparticles: Interaction with cells, cytokine production and enzymatic degradation, in: Lipospheres in Drug Targets and Delivery: Approaches, Methods and Applications (C. Nastruzzi, ed.), Routledge, 101-125, 2004

(46) Müller, R. H., Mehnert, W., Souto, E. B., Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for dermal delivery, in: Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methods, 4^th Edition (R. L. Bronaugh, H. I. Maibach, eds.), Marcel Dekker, 719-738, 2005

(47) Müller, R. H., Möschwitzer, J., Bushrab, F. N., Manufacturing of nanoparticles by milling and homogenisation techniques, in: Nanoparticle Technology for Drug Delivery (Gupta, Kompella, eds.), Marcel Dekker, 21-51, 2006

(48) Müller, R. H., Junghanns, J.-U., Drug nanocrystals/nanosuspensions for the delivery of poorly soluble drugs, in: Nanoparticulates as Drug Carriers (V. P. Torchilin, ed.), Imperial College Press, 307-328, 2006

(49) Müller, R. H., Souto, E. B., Göppert, T., Gohla, S., Production of biofunctionalized solid lipid nanoparticles (SLN) for site-specific drug delivery, in: Nanotechnologies for the Life Science: Biological and Pharmaceutical Materials (C. Kumar, ed.), Wiley-VCH, 287-303, 2006

(50) Müller, R. H., Göppert, T. M., Protein adsorption patterns on parenteral lipid formulations – key factor determining the in vivo fate, in: Role of Lipid Excipients in Modifying Oral and Parenteral Drug Delivery: Basic Principles and Biological Examples (Kishor M. Wasan, ed.), Wiley-VCH, 124-159, 2006

(51) Souto, E. B., Müller, R. H., Lipid nanoparticles (SLN and NLC) for drug delivery, in: Nanoparticles for pharmaceutical applications (A. Domb, Y Tobata, R. Kumar, S. Farber, eds.), American Scientific Publishers, 103-122, 2007

(52) Möschwitzer, J., Müller, R. H., Drug nanocrystals – the universal formulation approach for poorly soluble drugs, in: Nanoparticulate Drug Delivery Systems: Recent Trends and Emerging Technologies (D. Thassu, M. Deleers, Y. Pathak, eds.), Informa Healthcare, 2007

(53) Souto, E. B., Müller, R. H., Lipid nanoparticles (solid lipid nanoparticles and nanostructured lipid carriers) for cosmetic, dermal and transdermal applications, in: Nanoparticulate Drug Delivery Systems: Recent Trends and Emerging Technologies (D. Thassu, M. Deleers, Y. Pathak, eds.), CRC Press, 213-233, 2007

(54) Müller, R. H., Keck, C. M., Improvement of delivery & solubility of poorly soluble drugs by nanonisation, in: Konferenzdokumentation LTS Academy, 12-17, 4.-5. Oktober 2007

(55) Keck, C. M., Hommoss, A., Müller, R. H., Lipid nanoparticles (SLN, NLC, LDC) for the enhancement of oral absorption, in: Modified Release Drug Delivery Technology Vol. 2 (M. J. Rathbone, ed.), Informa Healthcare, 2008

(56) Souto, E. B., Petersen, R., Müller, R. H., Lipid nanoparticles with solid matrix for dermal delivery: solid lipid nanoparticles and nanostructured lipid carriers, in: Modified Release Drug Delivery Technology Vol. 2 (M. J. Rathbone, J. Hadgraft, M. S. Roberts, eds.), Informa Healthcare, 357-379, 2008

(57) Souto, E. B., Müller, R. H., Challenging cosmetics: Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers NLC), in: Science and Applications of Skin Delivery Systems (J. Wiechers, A. Kozlowski (eds.), Allured Publishing, 227-250, 2008

(58) Souto, E. B., Müller, R. H., Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) – lipid nanoparticles for medicals and pharmaceuticals, in: Encyclopedia of Nanoscience and Nanotechnology, 2^nd Edition (H. S. Nalwa, ed.), American Scientific Publishers, in press

(59) Souto, E. B., Teeranchaideekul, V., Boonme, P., Müller, R. H., Junyaprasert, V. B., Lipid-based nanocarriers for cutaneous administration of pharmaceutics, in: Encyclopedia of Nanoscience and Nanotechnology, 2^nd Edition (H. S. Nalwa, ed.), American Scientific Publishers, in press

(60) Keck, C. M., Müller, R. H., smartCrystals – review of the second generation of drug nanocrystals, in: Biomedical Nanotechnology, Materials for Nanomedicine, submitted

(61) Souto, E. B., Müller, R. H., Lipid nanoparticles – effect on bioavailability and pharmacokinetic changes, in: Handbook of Experimental Pharmacology – Novel Drug Delivery Approaches, Springer Publishing House, accepted

(62) Souto, E. B., Keck, C., Müller, R. H., Lipid nanoparticles (SLN, NLC) as nanocarriers for cosmetic applications: properties, production & cosmetic formulations, in: Research advances on Cosmetic Science (R. M. Mohan, ed.), Global India Network, in press

Refereed papers:

(1) Müller, B. W. und Müller, R. H., Particle Size Analysis of Latex Suspensions and Microemulsions by Photon Correlation Spectroscopy, J. Pharm. Sci. 73 (7), 915-918, 1984

(2) Müller, B. W. und Müller, R. H., Particle Size Distributions and Particle Size Alterations in Microemulsions, J. Pharm. Sci. 73 (7), 919-922, 1984

(3) Müller, B. W., Merz, J. und Müller, R. H., Simultane Bestimmung von elektrophoretischer Beweglichkeit und Teilchengröße bei überlagerter Konvektion an Suspensionen und Emulsionen, Colloid & Polymer Sci. 263, 342-347, 1985

(4) Illum, L., Davis, S. S., Müller, R. H., Mak, E. und West, P., The organ distribution and circulation time of intravenously injected colloidal carriers sterically stabilized with a blockcopolymer - poloxamine 908, Life Sciences 40, 367-374, 1987

(5) Illum, L., Jacobsen, L. O., Müller, R. H., Mak, E. und Davis, S. S., Surface Characteristics and the Interaction of Colloidal Particles with Mouse Peritoneal Macrophages, Biomaterials 8, 113-117, 1987

(6) Koosha, F., Müller, R. H., Davis, S. S., Polyhydroxybutyrate as a Drug Carrier, Critical Reviews in Therapeutic Drug Carrier Systems 6, (2), 117-130, 1989

(7) Koosha, F., Müller, R. H., Davis, S. S. und Davies, M. C., The Surface Chemical Structure of Poly (ß-hydroxybutyrate) Microparticles Produced by Solvent Evaporation Process, J. Contr. Rel. 9, 149-157, 1989

(8) Davis, S. S., Illum, L., Müller, R. H., Landry, F., Wright, J., Harper, G., The Effect of Infused Fat Emulsions on Reticuloendothelial Function in the Rabbit, Clinical Nutrition 9, 260-265, 1990

(9) Lucks, J. S., Müller, B. W., Müller, R. H., Inorganic Suspensions - Interaction with Salts and Ionic Surfactants, Int. J. Pharm. 58, 229-235, 1990

(10) Müller, R. H., Lherm, C., Herbort, J., Couvreur, P., In Vitro Model for the Degradation of Alkylcyanoacrylate Nanoparticles, Biomaterials 11, 590-595, 1990

(11) Lucks, J. S., Müller, B. W., Müller, R. H., Polymeric and emulsion carriers - Interaction with antiflocculants and ionic surfactants, Int. J. Pharm. 63, 183-188, 1990

(12) Wallis, K. H., Müller, R. H., Stabilität von Poloxamer undPoloxamine Coatingfilmen auf Polystyrol Nanopartikeln, Acta Pharm. Technol. 36 (3), 127-132, 1990

(13) Carstensen, H., Müller, B. W., Müller, R. H., Adsorption of ethoxylated surfactants on nanoparticles. I. Characterization by Hydrophobic Interaction Chromatography, Int. J. Pharm. 67, 29-37, 1991

(14) Müller, R. H., Lherm, C., Herbort, J., Couvreur, P., Propidium Iodide Loaded Polyalkylcyanoacrylate Particles - Labelling Conditions and Loading Capacity, Colloid & Polym. Sci. 269, 147-152, 1991

(15) Stampa, B., Lucks, J. S., Müller, B. W., Müller, R. H., Electrophoretic properties of emulsions for parenteral nutrition determined by laser light scattering and application of the amplitude weighted phase structure function (AWPS), J. Coll. Interf. Sci. 143 (1), 188-194, 1991

(16) Lukowski, G., Müller, R. H., Müller, B. W., Dittgen, M., Acrylic acid copolymer nanoparticles for drug delivery. I: Characterization of the surface properties relevant for in vivo organ distribution, Int. J. Pharm. 84, 23-31, 1992

(17) Müller, R. H., Heinemann, S., Fat emulsions for parenteral nutrition I: Evaluation of microscopic and laser light scattering methods for the determination of the physical stability, Clinical Nutrition 11, 223-236, 1992

(18) Tröster, S. D., Wallis, K. H., Müller, R. H., Kreuter, J., Correlation of the surface hydrophobicity of ¹⁴C-poly (methyl methacrylate) nanoparticles to their body distribution, J. Control. Rel. 20, 247-260, 1992

(19) Müller, R. H., Wallis, K. H., Tröster, S. D., Kreuter, J., In vitro characterization of poly (methyl methacrylate) nanoparticles and correlation to their in vivo fate, J. Control. Rel. 20, 237-246, 1992

(20) Müller, R. H., Lherm, C., Herbort, J., Blunk, T., Couvreur, P., Alkylcyanoacrylate Drug Carriers I: Physicochemical Characterization of Nanoparticles with Different Alkyl Chain Length, Int. J. Pharm. 84, 1-11, 1992

(21) Lherm, C., Müller, R. H., Puisieux F., Couvreur, P., Alkylcyanoacrylate Drug Carriers II: Cytotoxicity of Cyanoacrylate Nanoparticles with Different Alkyl Chain Length, Int. J. Pharm. 84, 13-22, 1992

(22) Carstensen, H., Müller, R. H., Müller, B. W., Particle size, surface hydrophobicity and interaction with serum of parenteral fat emulsions and model drug carriers as parameters related to RES uptake, Clinical Nutrition 11, 289-297, 1992

(23) Rudt, S., Müller, R. H., In vitro phagocytosis assay of nano- and microparticles by chemiluminescence. I. Effect of analytical parameters, particle size and particle concentration, J. Control. Rel. 22, 263-272, 1992

(24) Lukowski, G., Müller, R. H., Müller, B. W., Dittgen, M., Acrylic acid copolymer nanoparticles for drug delivery. II: Characterization of nanoparticles surface-modified by adsorption of ethoxylated surfactants, Colloid & Polym. Sci. 271, 100-105, 1993

(25) Müller, R. H., Wallis, K. H., Surface modification of i.v. injectable biodegradable nanoparticles with poloxamer polymers and poloxamine 908, Int. J. Pharm. 89, 25-31, 1993

(26) Wesemeyer, H., Müller, B. W., Müller, R. H., Adsorption of ethoxylated surfactants on nanoparticles. II. Determination of adsorption enthalpy by microcalorimetry, Int. J. Pharm. 89, 33-40, 1993

(27) Müller, R. H., Heinemann, S., Fat emulsions for parenteral nutrition II: Characterization and physical long-term stability of Lipofundin MCT/LCT, Clinical Nutrition 12, 298-309, 1993

(28) Maaßen, S., Fattal, E., Müller, R. H., Couvreur, P., Cell cultures for the assessment of toxicity and uptake of polymeric particulate drug carriers, S.T.P. Pharma Sciences 3 (1), 11-22, 1993

(29) Rudt, S., Müller, R. H., In vitro phagocytosis assay of nano- and microparticles by chemiluminescence. II. Effect of surface modification by coating of particles with poloxamer on the phagocytic uptake, J. Control. Rel. 25, 51-59, 1993

(30) Rudt, S., Müller, R. H., In vitro phagocytosis assay of nano- and microparticles by chemiluminescence. III. Uptake of differently sized surface-modified particles, and its correlation to particle properties and in vivo distribution, Eur. J. Pharm. Sci. 1, 31-39, 1993

(31) Rudt, S., Wesemeyer, H., Müller, R. H., In vitro phagocytosis assay of nano- and microparticles by chemiluminescence. IV. Effect of surface modification by coating of particles with poloxamine and Antarox CO on the phagocytic uptake, J. Control. Rel. 25, 123-132, 1993

(32) Rudt, S., Müller, R. H., In vitro uptake of polystyrene latex particles and parenteral fat emulsions by human granulocytes, Int. J. Pharm. 99, 1-6, 1993

(33) Blunk, T., Hochstrasser, D. F., Sanchez, J.-C., Müller, B. W., Müller, R. H., Colloidal Carriers for Intravenous Drug Targeting: Plasma Protein Adsorption Patterns on Surface-Modified Latex Particles Evaluated by Two-dimensional Polyacrylamide Gel Electrophoresis, Electrophoresis 14, 1382-1387, 1993

(34) Schwarz, C., Mehnert, W., Lucks, J. S., Müller, R. H., Solid lipid nanoparticles (SLN) for controlled drug delivery. I. Production, characterization and sterilization, J. Control. Rel. 30, 83-96, 1994

(35) Bock, T. K., Lucks, J. S., Kleinebudde P., Müller R. H., Müller B. W., High Pressure Homogenisation of Parenteral Fat Emulsions - Influence of Process Parameters on Emulsion Quality, Eur. J. Pharm. Biopharm. 40 (3), 157-160, 1994

(36) Müller, R. H., Heinemann, S., Fat emulsions for parenteral nutrition III: Lipofundin MCT/LCT regimens for total parenteral nutrition (TPN) with low electrolyte load, Int. J. Pharm. 101, 175-189, 1994

(37) Müller, R. H., Heinemann, S., Fat emulsions for parenteral nutrition IV: Lipofundin MCT/LCT regimens for total parenteral nutrition (TPN) with high electrolyte load, Int. J. Pharm. 107, 121-132, 1994

(38) Paulke, B.-R., Möglich, P.-M., Knippel, E., Budde, A., Nitzsche, R., Müller, R. H., Electrophoretic 3D-mobility profiles of latex particles with different surface groups, Langmuir 11, 70-74, 1995

(39) Gref, R., Domb, A., Quellec, P., Blunk, T., Müller, R. H., Verbavatz, J. M., Langer, R., The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres, Adv. Drug Deliv. Rev. 16, 215-233, 1995

(40) Müller, R. H., Mehnert, W., Lucks, J. S., Schwarz, C., zur Mühlen, A., Weyhers, H., Freitas, C., Rühl, D., Solid Lipid Nanoparticles (SLN) - An Alternative Colloidal Carrier System for Controlled Drug Delivery, Eur. J. Pharm. Biopharm. 41 (1), 62-69, 1995

(41) Blunk, T., Lück, M., Calvör, A., Hochstrasser, D. F., Sanchez, J.-C., Müller, B. W., Müller, R. H., Kinetics of Plasma Protein Adsorption on Model Particles for Controlled Drug Delivery and Drug Targeting, Eur. J. Pharm. Biopharm. 42 (4), 262-268, 1996

(42) Zingel, C., Sachse, A., Rößling, G. L., Müller, R. H., Lyophilization and Rehydration of Iopromide-Carrying Liposomes, Int. J. Pharm. 144, 13-24, 1996

(43) Hedemann, H., Lück, M., Blunk, T., Frokjaer, S., Müller, R. H., Fat emulsions based on structured lipids (1,3-specific triglycerides): An investigation of the in vitro interaction with plasma protein, Clin. Nutr. 15, 175-178, 1996

(44) Müller, R. H., Maaßen, S., Weyhers, H., Specht, F., Lucks, J. S., Cytotoxicity of magnetite loaded polylactide, polylactide/glycolide particles and solid lipid nanoparticles (SLN), Int. J. Pharm. 138, 85-94, 1996

(45) Ehlers, S., Bucke, W., Leitzke, S., Fortmann, L., Smith, D., Hänsch, H., Hahn, H., Bancroft, G., Müller, R. H., Liposomal amikacin for treatment of M. avium infections in clinically relevant experimental settings, Int. J. Med. Microbiol. Virol. Parasitol. Infect. Dis. 284, 218-231, 1996

(46) Müller, R. H., Maaßen, S., Weyhers, H., Mehnert, W., Phagocytic uptake and cytotoxicity of solid lipid nanoparticles (SLN) sterically stabilized with Poloxamine 908 and Poloxamer 407, J. Drug Targeting 4 (3), 161-170, 1996

(47) Müller, R. H., Rühl, D., Lück, M., Paulke, B.-R., Influence of fluorescent labelling of polystyrene particles on phagocytic uptake, surface hydrophobicity and plasma protein adsorption, Pharm. Res. 14 (1), 18-24, 1997

(48) Diederichs, J. E., Müller R. H., Microviscosity Measurements: Theory and Application for Parenteral Fat Emulsions, Pharm. Tech., Jan. 1997, 41-56, 1997

(49) Almeida, A. J., Runge, S., Müller, R. H., Peptide-loaded Solid Lipid Nanoparticles (SLN): Influence of production parameters, Int. J. Pharm. 149, 255-265, 1997

(50) Müller, R. H., Maaßen, S., Schwarz, C., Mehnert, W., Solid Lipid Nanoparticles (SLN) formulation for human use: interaction with human granulocytes, J. Contr. Rel. 47, 261-269, 1997

(51) Rühl. D., Schulze-Forster, K., Müller, R. H., Interaction of differentiated HL60 cells with Poloxamer and Poloxamine surface modified model drug carriers, Eur. J. Pharm. Biopharm. 5, 147-153, 1996

(52) Müller, R. H., Rühl, D., Runge, S., Biodegradation of SLN as a Function of Lipase Incubation time, Int. J. Pharm. 144, 115-121,1997

(53) Müller, R. H., Rühl, D., Runge, S., Schulze-Forster, K., Mehnert, W., Cytotoxicity of Solid Lipid Nanoparticles as a Function of the Lipid Matrix and the Surfactant, Pharm. Res. 14 (4), 458-462, 1997

(54) Thode, K., Lück, M., Kresse, M., Semmler, W., Müller, R. H., Determination of Plasma Protein Adsorption on Magnetic Iron Oxides: Sample Preparation, Pharm. Res. 14 (7), 905-910, 1997

(55) Müller, R. H., Weyhers, H., zur Mühlen, A., Dingler, A., Mehnert, W., Solid Lipid Nanoparticles (SLN) - ein neuartiger Wirkstoff-Carrier für Kosmetika und Pharmazeutika, I. Systemeigenschaften, Herstellung und Scaling up, Pharm. Ind. 59 (5), 423-427, 1997

(56) Mehnert, W., zur Mühlen, A., Dingler, A., Weyhers, H., Müller, R. H., Solid Lipid Nanoparticles (SLN) - ein neuartiger Wirkstoff-Carrier für Kosmetika und Pharmazeutika, II. Wirkstoff-Inkorporation, Freisetzung und Sterilisierbarkeit, Pharm. Ind. 59 (6), 511-514, 1997

(57) Müller, R. H., Dingler, A., Weyhers, H., zur Mühlen, A., Mehnert, W., Solid Lipid Nanoparticles (SLN) - ein neuartiger Wirkstoff-Carrier für Kosmetika und Pharmazeutika, III. Langzeitstabilität, Gefrier- und Sprühtrocknung, Anwendung in Kosmetika und Pharmazeutika, Pharm. Ind. 59 (7), 614-619, 1997

(58) Müller, R. H. and Runge, S. A., Kontrolowane dawkowanie leku za pomoca koloidalnych nošników (Kontrollierte Arzneistoffapplikation mit kolloidalen Carriern), Roczniki Naukowe, 1997

(59) Lück, M., Schröder, W., Harnisch, S., Thode, K., Blunk, T., Paulke, B.-R., Kresse, M., Müller, R. H., Identification of plasma proteins facilitated by enrichment on particulate surfaces: Analysis by two-dimensional electrophoresis and N-terminal microsequencing, Electrophoresis 18, 2961-2967, 1997

(60) Lück, M., Paulke, B.-R., Schröder, W., Blunk, T., Müller, R. H., Analysis of plasma protein adsorption on polymeric nanoparticles with different surface characteristics, J. Biomed. Mat. Res., 478-485, 1997

(61) Bucke, W. E., Leitzke, S., Diederichs, J. E., Borner, K., Hahn, H., Ehlers, Müller, R. H., Surface-modified amikacin-liposomes: Organ distribution and interaction with plasma proteins, J. Drug Targ. 5 (2), 99-108, 1997

(62) Thode, K., Lück, M., Schröder, W., Kresse, M., Semmler, W., Müller, R. H., Influence of the sample preparation on plasma protein adsorption onto macromolecule stabilized iron oxide particles and N-terminal microsequencing of unknown proteins, J. Drug Targ. 5 (1), 35-43, 1997

(63) Müller, R .H., Peters, K., Nanosuspensions for the formulation of poorly soluble drugs. I. Preparation by a size-reduction technique, Int. J. Pharm. 160, 229-237, 1998

(64) Schuhmann, R., Müller, R. H., Optimierung der Probenaufbereitung für Coulter-Counter-Messungen, Pharm. Ind. 60 (2), 157-163, 1998

(65) Harnisch, S., Müller, R .H., Plasma protein adsorption patterns on emulsions for the parenteral administration: Establishment of a protocol for two-dimensional polyacrylamide electrophoresis. Electrophoresis, 19, 349-354,1998

(66) Lück, M., Pistel, K. F., Li, Y.-X., Blunk, T., Müller, R. H., Kissel, T., Plasma protein adsorption on biodegradable microspheres consisting of poly (DL-lactide-co-glycolide), poly(L-lactide) or ABA triblock copolymers containing poly(oxyethylene): Influence of production method and polymer composition, J. Control. Rel. 55, 107-120, 1998

(67) Leitzke, S., Bucke, W., Borner, K., Müller, R. H., Hahn, H., Ehlers, S., Rationale and efficacy of prolonged-interval treatment using liposome-encapsulated Amikacin in experimental M. avium infection, Antimicrob. Agents Chemother., 459-461, 1998

(68) Freitas, C., Müller, R. H., Spray Drying of Solid Lipid Nanoparticles (SLN™), Eur. J. Pharm. Biopharm. 46, 145-151, 1998

(69) Freitas, C., Müller, R. H., Effect of light and temperature on zeta potential and physical stability in Solid Lipid Nanoparticle (SLN™) Dispersions. Int. J. Pharm. 168, 221-229, 1998

(70) Thode, K., Lück, M., Schröder, W., Blunk, T., Müller, R. H., Kresse, M., The influence of the sample preparation on plasma protein adsorption patterns on polysaccharide-stabilized iron oxide particles and N-terminal microsequencing of unknown proteins, J. Drug. Targ. 5 (6), 459-469, 1998

(71) Freitas, C., Müller, R. H., Correlation between long-term stability of solid lipid nanoparticles (SLN™) and crystallinity of the lipid phase, Eur. J. Pharm. Biopharm. 47, 125-132, 1999

(72) Freitas, C., Müller, R. H., Stability Determination of Solid Lipid Nanoparticles (SLN™) in Aqueous Dispersion after Addition of Electrolyte, Journal of Microencapsulation 16 (1), 59-71, 1999

(73) Müller, R. H., Dobrucki, R., Radomska, A., Solid lipid nanoparticles as a new formulation with retinol, Acta Poloniae Pharmaceutica 56 (2), 117-120, 1999

(74) Müller, R. H., Böhm, B. H. L., Grau, M. J., Nanosuspensions - Formulierungen für schwerlösliche Arzneistoffe mit geringer Bioverfügbarkeit: I. Herstellung und Eigenschaften, Pharm. Ind. 61 (1), 74-78, 1999

(75) Müller, R. H., Böhm, B. H. L., Grau, M. J., Nanosuspensionen - Formulierungen für schwerlösliche Arzneistoffe mit geringer Bioverfügbarkeit: II. Stabilität, biopharmazeutische Aspekte, mögliche Arzneiformen und Zulassungsfragen, Pharm. Ind. 61 (2), 175-178, 1999

(76) Pinto, J. F., Müller, R. H., Pellets as carriers of solid lipid nanoparticles (SLN™) for oral administration of drugs, Die Pharmazie 54, 506-509, 1999

(77) Müller, R. H., Olbrich, C., Solid Lipid Nanoparticles (SLN): Phagocytic uptake, in vitro cytotoxity and in vivo biodegradation, 1^st Communication, Pharm. Ind. 61, 462-467, 1999

(78) Müller, R. H., Olbrich, C., Solid Lipid Nanoparticles (SLN): Phagocytic uptake, in vitro cytotoxity and in vivo biodegradation, 2^nd Communication, Pharm. Ind. 61, 564-569, 1999

(79) Olbrich, C., Müller, R. H., Enzymatic degradation of SLN - Effect of surfactant and surfactant mixtures, Int. J. Pharm. 180, 31-39, 1999

(80) Peters, K., Müller, R. H., Craig, D. Q. M., An Investigation into the Distribution of Lecithins [between Vesicles and Drug Particles] in Nanosuspension Systems using Low Frequency Dielectric Spectroscopy, Int. J. Pharm. 184, 53-61, 1999

(81) Dingler, A., Blum, R. P., Niehus, H., Gohla, S., Müller, R. H., Solid lipid nanoparticles (SLN^TM/Lipopearls^TM) - A pharmaceutical and cosmetic carrier for the application of vitamin E in dermal products, Journal of Microencapsulation 16 (6), 751-767, 1999

(82) Lück, M., Schröder, W., Paulke, B.-R., Blunk, T., Müller, R. H., Complement Activation by Model Drug Carries for Intravenous Application: Determination by Two-Dimensional Electrophoresis, Biomaterials 20, 2063-2068, 1999

(83) Peracchia, M. T., Harnisch, S., Pinto-Alphandary, H., Gulik, A., Dedieu, J. C., Desmaele, D., d‘Angelo, J., Müller, R. H., Couvreur, P., Visualization of in vitro protein-rejecting properties of pegylated stealth^â polycyanoacrylate nanoparticles, Biomaterials 20, 1269-1275, 1999

(84) Borner, K., Hartwig, H., Leitzke, S., Hahn, H., Müller, R. H., Ehlers, S., HPLC determination of clofazimine in tissues and serum of mice after intravenous administration of nanocrystalline or liposomal formulations, Antimicrob. Agents Chemother. 11, 75-79, 1999

(85) Anger, S., Caldwell, K., Niehus, H., Müller, R. H., High Resolution Size Determination of 20 nm Colloidal Gold Particles by Sedimentation Field Flow Fractionation, Pharm. Res.16 (11), 1743-1747, 1999

(86) Böhm, B., Müller, R. H., Lab-scale production unit design for nanosuspensions of sparingly soluble cytotoxic drugs, Pharm. Science & Technology Today 2 (8), 336-339, 1999

(87) Müller, R. H., Olbrich, C., Solid Lipid Nanoparticles (SLN): Phagocytic uptake, in vitro cytotoxity and in vivo biodegradation, Drugs 42, 65-88, 1999

(88) Radomska, R., Dobrucki, R., Müller, R. H., Chemical stability of the lipid matrices of solid lipid nanoparticles (SLN) – development of the analytical method and determination of long-term stability, Die Pharmazie, 54, 903-909, 1999

(89) Harnisch, S., Müller, R.H., Adsorption kinetics of plasma proteins on oil-in-water emulsions for parenteral nutrition, Eur. J. Pharm. Biopharm. 49, 41-46, 2000

(90) Müller, R. H., Harnisch, S., Physico-chemical characterization of propofol-loaded emulsions and interaction with plasma proteins, European Journal of Hospital Pharmacy 6/1, 24-31, 2000

(91) Peters, K., Leitzke, S., Diederichs, J. E., Borner, K., Hahn, H., Müller, R. H., Ehlers, S., Preparation of a clofazimine nanosuspension for intravenous use and evaluation of its therapeutic efficacy in murine Mycobacterium avium infection, Journal of Antimicrobial Chemotherapy 45 (1), 77-83, 2000

(92) Anger, S., Caldwell, D., Müller, R. H., Charakterisierung von Molekülen, Kolloiden und Partikeln mit der Field Flow Fractionation, Pharm. Ind. 62, 2, 150-156, 2000

(93) Gref, R., Quellec, P., Marchand M., Dellacherie, E., Lück, M., Harnisch, S., Blunk, T., Müller, R. H., „Stealth“ corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption, Colloids and Surfaces B: Biointerfaces 18 (3-4), 301-313, 2000

(94) Geßner, A., Paulke, B.-R., Müller, R. H., Analysis of plasma protein adsorption onto polystyrene particles by two-dimensional electrophoresis: Comparison of sample application and isoelectric focusing techniques, Electrophoresis 21, 2438-2442, 2000

(95) Rudolph, C., Lausier, J., Naundorf, S., Müller, R. H., Rosenecker, J., In vivo gene delivery to the lung using polyethylenimine and fractured polyamidoamine dendrimers, The Journal of Gene Medicine 2, 269-278, 2000

(96) Jacobs, C., Kayser, O., Müller, R. H., Nanosuspensions as a new approach for the formulation for the poorly soluble drug tarazepide, Int. J. Pharm.196, 161-164, 2000

(97) Liedtke, S., Wissing, S., Müller, R. H., Mäder, K., Influence of high pressure homogenisation equipment on nanodispersions characteristics, Int. J. Pharm.196, 183-185, 2000

(98) Schöler, N., Zimmermann, E., Katzfey, U., Hahn, H., Müller, R. H., Liesenfeld, O., Preserved solid lipid nanoparticles (SLN) at low concentrations do cause neither direct nor indirect cytotoxic effects in peritoneal macrophages, Int. J. Pharm.196, 235-239, 2000

(99) Krause, K. P., Kayser, O., Mäder, K., Gust, R., Müller, R. H., Heavy metal contamination of nanosuspensions produced by high-pressure homogenisation, Int. J. Pharm.196, 169-172, 2000

(100)Grau, M. J., Kayser, O., Müller, R. H., Nanosuspensions of poorly soluble drugs – reproducibility of small scale production, Int. J. Pharm.196, 155-157, 2000

(101)Seehof, K., Kresse, M., Mäder, K., Müller, R. H., Interactions of nanoparticles with body proteins – impovement of 2D-PAGE-analysis by internal standard, Int. J. Pharm.196, 231-234, 2000

(102)Geßner, A., Waicz, R., Lieske, A., Paulke, B.-R., Mäder, K., Müller, R. H., Nanoparticles with decreasing surface hydrophobicities: influence on plasma protein adsorption, Int. J. Pharm.196, 245-249, 2000

(103)Lippacher, A., Müller, R. H., Mäder, K., Investigation on the viscoelastic properties of lipid based colloidal drug carriers, Int. J. Pharm. 196, 227-230, 2000

(104)Zimmermann, E., Müller, R. H., Mäder, K., Influence of different parameters on reconstitution of lyophilized SLN, Int. J. Pharm. 196, 211-213, 2000

(105)Müller, R. H., Mäder, K., Gohla, S., Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art, Eur. J. Pharm. Biopharm. 50, 161-177, 2000

(106)Buszello, K., Harnisch, S., Müller, R. H., Müller, B. W., The influence of alkali fatty acids on the properties and the stability of parenteral O/W emulsions modified with Solutol HS 15^â, Eur. J. Pharm. Biopharm. 49, 143-149, 2000

(107)Krause, W., Schlichter-Hackmann, N., Maier, F. K., Müller, R. H., Dendrimers in Diagnostics, in: Topics in Current Chemistry. Vol. 210, 261-308, 2000

(108)Schöler, N., Zimmermann, E., Katzfey, U., Hahn, H., Müller, R. H., Liesenfeld, O., Effect of solid lipid nanoparticles (SLN) on cytokine production and the viability of murine peritoneal macrophages, Journal of Microencapsulation, 17 (5), 639-650, 2000

(109)Thode, K., Müller, R. H., Kresse, M., Two-time window and multi-angle photon correlation spectroscopy size & zeta potential analysis – highly sensitive rapid assay for dispersion stability, J. Pharm. Sci. 89(10), 1317-1324, 2000

(110)Krause, K., Müller, R. H., Production and characterisation of highly concentrated nanosuspensions by high pressure homogenisation, Int. J. Pharm. 214, 21-24, 2001

(111)Lippacher, A., Müller, R. H., Mäder, K., Preparation of semisolid drug carriers for topical application based on solid lipid nanoparticles, Int. J. Pharm. 214, 9-12, 2001

(112)Jacobs, C., Kayser, O., Müller, R. H., Production and characterisation of mucoadhesive nanosuspensions for the formulation of bupravaquone, Int. J. Pharm. 214, 3-7, 2001

(113)Geßner, A., Olbrich, C., Schröder, W., Kayser, O., Müller, R. H., The role of plasma proteins in brain targeting: species dependent protein adsorption patterns on brain-specific lipid drug conjugate (LDC) nanoparticles, Int. J. Pharm. 214, 87-91, 2001

(114)Demirel, M., Yazan, Y., Müller, R. H., Kilic, F., Bozan, B., Formulation and in vitro-in vivo evaluation of Piribedil solid lipid particles, Journal of Microencapsulation 18 (3), 359-371, 2001

(115)Schöler, N., Olbrich, C., Tabatt, K., Müller, R. H., Hahn, H., Liesenfeld, O., Surfactant, but not the size of solid lipid nanoparticles (SLN) influences viability and cytokine production of macrophages, Int. J. Pharm. 221, 57-67, 2001

(116)Müller, R. H., Jacobs, C., Kayser, O., Nanosuspensions as particulate drug formulations in therapy – Rationale for Development and what we can expect for the future, in: Advanced Drug Delivery Reviews (ADDR) 47, 3-19, 2001

(117)Schöler, N., Krause, K., Kayser, O., Müller, R. H., Hartwig, H., Hahn, H., Liesenfeld, O., Atovaquone nanosuspensions show excellent therapeutic effect in a new murine model of reactivated toxoplasmosis, Antimicrob. Agents Chemother., 1771-1779, 2001

(118)Wissing, S. A., Müller, R. H., A novel sunscreen system based on tocopherol acetate incorporated into solid lipid nanoparticles (SLN), Int. J. Cosmet. Sci. 23, 233-243, 2001

(119)Müller, R. H., Wissing, S. A., Radomska, A., Clinical batch production of peptide-loaded nanoparticles, NewDrugs 1, 72-74, 2001

(120)Krause, K. Müller, R. H., Production of aqueous shellac dispersions by high pressure homogenisation, Int. J. Pharm. 223, 89-92, 2001

(121)Radtke, M., Müller, R. H., NLC^® – Nanostructured lipid carriers: the new generation of lipid drug carriers, NewDrugs 2, 48-52, 2001

(122)Lind, K., Kresse, M., Müller, R. H., Evaluation of desorption of proteins adsorbed to hydrophilic surfaces by two-dimensional electrophoresis, Proteomics 1, 1059-1066, 2001

(123)Zimmermann, E., Müller, R. H., Electrolyte- and pH-stability of aqueous solid lipid nanoparticle (SLN^TM) dispersions in artificial gastrointestinal (GI) media, Eur. J. Pharm. Biopharm. 52, 203-210, 2001

(124)Wissing, S. A., Mäder, K., Müller, R. H., Solid lipid nanoparticles (SLN^TM) – a novel carrier for UV blockers, Die Pharmazie 10, 783-786, 2001

(125)Wissing, S. A., Lippacher, A., Müller, R. H., Investigations on the occlusive properties of solid lipid nanoparticles (SLN^TM), International Journal of Cosmetic Science 52, 313-324, 2001

(126)Olbrich, C., Bakowsky, U., Lehr, C.-M., Müller, R. H., Kneuer, C., Cationic solid-lipid nanoparticles can efficiently bind and transfect plasmid DNA, Journal of Controlled Release 77, 345-355, 2001

(127)Seehof, K., Kresse, M., Müller, R. H., Comparison of protein adsorption patterns onto differently charged hydrophilic superparamagnetic iron oxide (SPIO) particles obtained in vitro and ex vivo, Electrophoresis 22 (16), 3514-3521, 2001

(128)Harnisch, S., Schuhmann, R., Harnisch, Jacob F., Müller, R. H., Differences in the coalescence kinetics of fat emulsions in dependence on the amount of fat and age, Die Pharmazie 57, 54-58, 2002

(129)Schöler, N., Hahn, H., Müller, R. H., Liesenfeld, O., Effect of lipid matrix and size of solid lipid nanoparticles (SLN) on the viability and cytokine production of macrophages, Int. J. Pharm. 231, 167-176, 2002

(130)Lind, Kathrin, Kresse, M., Debus, N. P., Müller, R. H., A novel formulation for superparamagnetic iron oxide (SPIO) particles enhancing MR lymphography: comparison of physicochemical properties and the in vivo behaviour, J. Drug. Targeting, 10 (3), 221-230, 2002

(131)Olbrich, C., Kayser, O., Müller, R. H., Lipase degradation of Dynasan 114 and Dynasan 116 Solid Lipid Nanoparticles (SLN) – effect of surfactants, storage time and crystallinity, Int. J. Pharm. 237, 119-128, 2002

(132)Funke, A. P., Schiller, R., Motzkus, H. W., Günther, C., Müller, R. H., Lipp, R., Transdermal delivery of highly lipophilic drugs: In-vitro fluxus of antiestrogens, permeation enhancers and solvents from liquid formulations, Pharm. Res. 19, No. 5, 661-668, 2002

(133)Müller, R. H., Schmidt, S., PathFinder technology for the delivery of drugs to the brain, NewDrugs 2, 38-42, 2002

(134)Geßner, A., Lieske, A., Paulke, B. R., Müller, R. H., Influence of surface charge density on protein adsorption on polymeric nanoparticles: analysis by two-dimensional electrophoresis, Eur. J: of Pharm. and Biopharm. 54 (2), 165-170, 2002

(135)Lippacher, A., Müller, R. H., Mäder, K., Semisolid SLN^TM dispersions for topical application: influence of formulation and production parameters on microstructure, Eur. J. Pharm. Biopharm. 53 (2), 155-160, 2002

(136)Funke, A., Günther, C., Müller, R. H., Lipp, R., In-vitro release and transdermal fluxes of a highly lipophilic drug and of enhancers from matrix TDS, J. Control. Rel. 82, 63-70, 2002

(137)Wissing, S., Müller, R. H., Solid lipid nanoparticles as carrier for sunscreens: in vitro release and in vivo skin penetration, J. Control. Rel. 81, 225-233, 2002

(138)Rudolph, C., Müller, R. H., Rosenecker, J., Jet nebulisation of PEI/DANN polyplexes: physical stability and in vitro gene delivery efficiency, Journal of Gene Medicine 4 (1), 66-74, 2002

(139)Jacobs, C., Müller, R. H., Production and characterizatoin of a budesonide nanosuspension for pulmonary administration, Pharm. Res. 19 (2), 189-194, 2002

(140)Müller, R. H., Jacobs, C., Buparvaquone mucoadhesive nanosuspensions: Preparation, optimisation and long-term stability, Int. J. Pharm. 237, 151-161 (2002)

(141)Olbrich, C., Geßner, A., Kayser, O., Müller, R. H., Lipid-drug conjugate (LDC) nanoparticles as novel carrier system for the hydrophilic antitrypanosomal drug Diminazenediaceturate, Journal of Drug Targeting 10 (5), 387-396, 2002

(142)Müller, R. H., Radtke, M., Wissing, S. A., Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations, Advanced Drug Delivery Reviews (ADDR) 54 Suppl. 1, S131-S155, 2002

(143)Rudolph, C., Schillinger, U., Plank, C., Geßner, A., Nicklaus, P., Müller, R. H., Rosenecker, J., Nonviral gene delivery to the lung with copolymer protected and transferring-modified polyethylenimine, Biochimica et Biophysica Acta 1573, 75-83, 2002

(144)Müller, R. H., Radtke, M., Wissing, S. A., Nanostructured lipid matrices for improved microencapsulation of drugs, Int. J. Pharm. 242, 121-128, 2002

(145)Olbrich, C., Kayser, O., Müller, R. H., Enzymatic degradation of Dynasan 114 Solid Lipid Nanoparticles (SLN) – effect of surfactants and particle size, Journal of Nanoparticle Research 4, 121-129, 2002

(146)Olbrich, C., Müller, R. H., Tabatt, K., Kayser, O., Schulze, C., Schade, R., Stable biocompatible adjuvants – a new type of adjuvant based on solid lipid nanoparticles: A Study on cytotoxicity, compatibility and efficacy in chicken, Atla 30, 443.458, 2002

(147)Wissing, S. A., Müller, R. H., The influence of the crystallinity of lipid nanoparticles on their occlusive properties, Int. J. Pharm. 242, 377-379, 2002

(148)Wissing, S. A., Müller, R. H., The development of an improved carrier system for sunscreen formulations based on crystalline lipid nanoparticles, Int. J. Pharm. 242, 373-375, 2002

(149)Rosenecker, J., Naundorf., S., Gersting, S. W., Hauck, R. W., Geßner, A. Nicklaus, P., Müller, R. H., Rudolph, C., Interaction of bronchoalveolar lavage fluid (BALF) with polyplexes and lipoplexes: analysing the role of proteins and glycoproteins, Journal of Gene Medicine 5(1), 49-60, 2003

(150)Wissing, S. A., Müller, R. H., Cosmetic applications for solid lipid nanoparticles (SLN), Int. J. Pharm. 254, 65-68, 2003

(151)Schmidt, S., Müller, R. H., Plasma protein adsorption patterns on surfaces of Amphotericin B-containing fat emulsions, Int. J. Pharm. 254, 3-5, 2003

(152)Rudolph, C., Plank, C., Lausier, J., Schillinger, U., Müller, R. H., Rosenecker, J., Oligomers of the arginine-rich motif of the HIV-1 TAT protein: a novel approach for nonviral gene delivery, PNAS, Journal of Biological Chemistry 278 (13), 11411-11418, 2003

(153)Rank, F., Wozniewski, T., Müller, R. H., IMS – the future for chemical-pharmaceutical industry?, NewDrugs 3, 22-24, 2003

(154)Akkar, A., Müller, R. H., Formulation of i. v. Carbamazepin emulsions by SolEmuls technology, Eur. J. Pharm. Biopharm. 55, 305-312, 2003

(155)Akkar, A., Müller, R. H., Intravenous itraconazole emulsions produced by SolEmuls Technology, Eur. J. Pharm. Biopharm. 56, 29-36, 2003

(156)Wissing, S., Müller, R. H., The influence of solid lipid nanoparticles (SLN) on skin hydration and viscoelasticity – in vivo study, Eur. J. Pharm. Biopharm. 56, 67-72, 2003

(157)Göppert, T. M., Müller, R. H., Plasma protein interactions of Tween 80- and poloxamer 188-stabilized SLN. Journal of Drug Targeting 11 (4), 225-231, 2003

(158)Funke, A., Günther, C., Müller, R. H., Lipp, R., Development of matrix patches for transdermal delivery of a highly lipophilic antiestrogen, Drug Dev. Ind. Pharm. 29 (7), 785-793, 2003

(159)Bushrab, F. N., Müller, R. H., Nanocrystals of poorly soluble drugs for oral administration, NewDrugs 5, 20-22, 2003

(160)Wissing, S. A., Saupe, A., Müller, R. H., Nanostructured lipid carriers (NLC) for topical use – an overview, Eurocosmetics 5, 14-17, 2003

(161)Geßner, A., Lieske, A., Paulke, B.-R., Müller, R. H., Functional groups on polystyrene model nanoparticles: Influence on protein adsorption, Journal of Biomedical Materials Research 65A, 319-326, 2003

(162)Müller, R. H., Schmidt, S., Buttle, S., Akkar, A., Schmitt, J., Brömer, S., SolEmuls^â – Novel technology for the formulation of i.v. emulsions with poorly soluble drugs, Int. J. Pharm. 269, 293-302, 2004

(163)Tabatt, K., Sameti, A., Olbrich, C., Müller, R. H., Lehr, C.-M., Effect of cationic lipid and matrix lipid composition on solid lipid nanoparticle-mediated gene transfer, Eur. J. Pharm. Biopharm. 57 (2), 155-162, 2004

(164)Olbrich, C., Geßner, A., Schröder, Kayser, O., Müller, R. H., Lipid-drug conjugate (LDC) nanoparticles of the hydrophilic drug diminazene - cytotoxicity testing and mouse serum adsorption, J. Controlled Release, 96 (3), 425-435, 2004

(165)Olbrich, C., Schöler, N., Tabatt, K., Kayser, O., Müller, R. H., Cytotoxicity studies of Solid Lipid Nanoparticles (SLN) on RAW 264.7 macrophages – impact of phagocytosis on viability and cytokine production, J. Pharm. Pharmacol. 56 (7), 883-891, 2004

(166)Rudolph, C., Schillinger, U., Ortiz, A., Tabatt, K., Plank, C., Müller, R. H., Rosenecker, J., Application of novel Solid Lipid Nanoparticle (SLN)-gene vector formulations based on a dimeric HIV-1 TAT-peptide in vitro and in vivo, Pharm. Res. 21 (9), 1662-1669, 2004

(167)Wissing, S., Müller, R. H., Manthei, L., Mayer, C., Structural characterization of Q10-loaded SLN by NMR spectroscopy, Pharm. Res. 21 (3), 400-405, 2004

(168)Rank, F., Scheuermann, H.-J., Wozniewski, T., Müller, R. H., Qualität, Umweltschutz und Sicherheit 2003 – Ein Einblick in die Organisation von Managementsystemen im Bereich der Produktion chemisch-pharmazeutischer Unternehmen in Deutschland, Pharm. Ind. 66 (7), 848-852, 2004

(169)Wissing, S. A., Kayser, O., Müller, R. H., Solid lipid nanoparticles for parenteral drug delivery, Advanced Drug Delivery Reviews (ADDR) 56, 1257-1272, 2004

(170)Göppert, T. M., Müller, R. H., Alternative sample preparation prior to two-dimensional electrophoresis protein analysis on solid lipid nanoparticles: development of optimized sample preparations method, Electrophoresis 25 (1), 134-140, 2004

(171)Akkar, A. Namsolleck, P., Blaut, M., Müller, R. H., Solubilising poorly soluble antimycotic agents by emulsification via a solvent-free process, AAPS PharmSciTech, 5 (2), Article 24, 2004

(172)Souto, E. B., Wissing, S. A., Barbosa, C. M., Müller, R. H., Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery, Int. J. Pharm. 278, 71-77, 2004

(173)Üner, M., Wissing, S. A., Yener, G., Müller, R. H., Influence of surfactants on the physical stability of solid lipid nanoparticle (SLN) formulations, Pharmazie 59, short communications, 331-332, 2004

(174)Tabatt, K., Kneuer, C., Sameti, M., Olbrich, C., Müller, R. H., Lehr, C.-M., Bakowsky, U., Transfection with solid lipid nanoparticles and liposomes: comparison of physical and biological performance, J. Control. Rel., 97, 321-332, 2004

(175)Souto, E. B., Wissing, S. A., Barbosa, C. M., Müller, R. H., Evaluation of the physical stability of SLN and NLC before and after incorporation into hydrogel formulations, Eur. J. Pharm. Biopharm. 58, 83-90, 2004

(176)Müller, R. H., Keck, C. M., Drug delivery to the brain – realisation by novel drug carriers, Journal of Nanoscience and Nanotechnology 4 (5), 471-483, 2004

(177)Souto, E. B., Wissing, S. A., Barbosa, C. M., Müller, R. H., Comparative study between the viscoelastic behaviour of different lipid nanoparticle formulations, International Journal of Cosmetic Science 55, 463-471, 2004

(178)Müller, R. H., Keck, C. M., Challenges and solutions for the delivery of biotech drugs, Journal of Biotechnology 113, 151-170, 2004

(179)Möschwitzer, J., Achleitner, G., Pomper, H., Müller, R. H., Development of an intravenously injectable chemically stable aqueous omeprazole formulation using nanosuspension technology, Eur. J. Pharm. Biopharm. 58, 615-619, 2004

(180)Rank, F., Wozniewski, T., Scheuermann, H.-J., Müller, R. H., Compliance aus Sicht der Industrie, Pharmazeutische Zeitung 40, 50-52, 2004

(181)Hernandez-Trejo, N., Hampe, A., Müller, R. H., A thin layer chromatography method to identify oxaliplatin in aqueous solution, Pharm.Ind. 66 (12), 1545-1550, 2004

(182)Akkar, A., Müller, R. H., Solubilisation by emulsification – novel formulation principle of poorly soluble drugs for intravenous administration, Pharm.Ind. 66 (12), 1537-1544, 2004

(183)Lippacher, A., Müller, R. H., Mäder, K., Liquid and semisolid SLN^TM dispersions for topical application: rheological characterization, Eur. J. Pharm. Biopharm. 58, 561-567, 2004

(184)Dunay, I. R., Heimesaat, M. M., Bushrab, F. N., Müller, R. H., Stocker, H., Arasteh, K., Kurowski, M., Fitzner, R., Borner, K., Liesenfeld, O., Atovaquone maintenance therapy prevents reactivation of toxoplasmic encephalitis in a murine model of reactivated toxoplasmosis, Antimicrob. Agents Chemother. 48 (12), 4848-4854, 2004

(185)Labarre, D., Vauthier, C., Chauvierre, C., Petri, B., Müller, R. H., Chehimi, M. M., Interactions of blood proteins with poly (isobutyleyanoacrylate) nanoparticles decorated with a polysaccharidic brush, Journal of Biomaterials 26, 5075-5084, 2005

(186)Schalper, K., Harnisch, S., Müller, R. H., Hildebrand, G. E., Preparation of microparticles by micromixers: characterization of oil/water process and prediction of particle size, Pharmaceutical Research 22 (2), 276-284, 2005

(187)Souto, E. B., Anselmi, C., Centini, M., Müller, R. H., Preparation and characterization of N-dodecyl-ferulate-loaded solid lipid nanoparticles (SLN), Int. J. Pharm. 295, 261-268, 2005

(188)Göppert, T. M., Müller, R. H., Polysorbate-stabilized solid lipid nanoparticles as colloidal carriers for intravenous targeting of drugs to the brain: Comparison of plasma protein adsorption patterns, Journal of Drug Targeting 13 (3), 179-187, 2005

(189)Junghanns, J.-U., Jacob, R., Müller, R. H., SolEmuls – a convenient way to overcome solubility problems, NewDrugs 3, 10-11, 2005

(190)Göppert, T. M., Müller, R. H., Protein adsorption patterns on poloxamer- and poloxamine-stabilized solid lipid nanoparticles (SLN), Eur. J. Pharm. Biopharm. 60, 361-372, 2005

(191)Zimmermann, E., Souto, E. B., Müller, R. H., Physicochemical investigations on the structure of drug-free and drug-loaded solid lipid nanoparticles (SLN^TM) by means of DSC and ¹H-NMR, Die Pharmazie 60, 508-513, 2005

(192)Göppert, T., Müller, R. H., Adsorption kinetics of plasma proteins on solid lipid nanoparticles for drug targeting, Int. J. Pharm. 302, 172-186, 2005

(193)Souto, E. B., Gohla, S. H., Müller, R. H., Rheology of nanostructured lipid carriers (NLC) suspended in viscoelastic medium, Die Pharmazie 60, 671-673, 2005

(194)Üner, M., Wissing, S. A., Yener, G., Müller, R. H., Skin moisturizing effect and skin penetration of ascorbyl palmitate entrapped in solid lipid nanoparticles (SLN) and nanostructured lipid carriers UNLC) incorporated in hydrogel, Die Pharmazie 60, 751-755, 2005

(195)Üner, M., Wissing, S. A., Yener, G., Müller, R. H., Solid lipid nanoparticles (SLN) and nanostructured lipid carries (NLC) for application of ascorbyl palmitate, Die Pharmazie 60, 577582, 2005

(196)Saupe, A., Wissing, S. A., Lenk, A., Schmidt, C., Müller, R. H., Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) – strucutral investigations on two different carrier systems, Bio-Medical Material and Engineering 15, 393-402, 2005

(197)Rank, F., Scheuermann, H.-J., Wozniewski, T., Müller, R. H., Managing compliance in the production – insights and comparisons in chemical-pharmaceutical companies, PDA Journal of Pharmaceutical Science and Technology, 233-239, 2005

(198)Souto, E. B., Müller, R. H., SLN and NLC for topical delivery of ketoconazole, Journal of Microencapsulation 22 (5), 501-510, 2005

(199)Hernandez-Trejo, N., Kayser, O., Steckel, H., Müller, R. H., Characterization of nebulized buparvaquone nanosuspensions – effect of nebulization technology, Journal of Drug Targeting 13 (8-9), 499-507, 2005

(200)Tamilvanan, S., Schmidt, S., Müller, R. H., Benita, S., In vitro adsorption of plasma proteins onto the surface (charges) modified-submicron emulsions for intravenous administration, Eur. J. Pharm. Biopharm. 59, 1-7, 2005

(201)Weyhers, H., Lück, M., Mehnert, W., Souto, E. B., Müller, R. H., Surface modified Solid Lipid Nanoparticles (SLN) analysis of plasma protein adsorption patterns by two-dimensional polyacrylamide gel electrophoresis (2-D PAGE), International Journal of Molecular Medicine and Analytical Sciences 1 (2), 196-201, 2005

(202)Işcan, Y, Wissing, S. A., Hekimoğlu, S., Müller, R. H., Solid lipid nanoparticles (SLN) for topical drug delivery: incorporation of the lipophilic drugs deet and vitamin K, Die Pharmazie, 2005

(203)Radtke, M., Souto, E. M., Müller, R. H., Nanostructured Lipid Carriers (NC) - The novel generation of solid lipid drug carriers, Pharmaceutical Technology Europe 17 (4), 45-50, 2005

(204)Mocha, D., Scheuermann, H.-J., Skuballa, B., Ottnad, M., Wozniewski, T., Müller, R. H., Integration von internen Qualitäts-, Sicherheits- und Umweltschutzaudits in Pharmazeutischen Unternehmen, 1. Schnittstellenanalyse, Pharm.Ind. 67 (9), 1023-1030, 2005

(205)Mocha, D., Scheuermann, H.-J., Skuballa, B., Ottnad, M., Wozniewski, T., Müller, R. H., Integration von internen Qualitäts-, Sicherheits- und Umweltschutzaudits in Pharmazeutischen Unternehmen, 2. Konzeptionierung von Integrationsmodellen, Pharm.Ind. 67 (10), 1148-1152, 2005

(206)Mocha, D., Scheuermann, H.-J., Skuballa, B., Ottnad, M., Wozniewski, T., Müller, R. H., Integration von internen Qualitäts-, Sicherheits- und Umweltschutzaudits in Pharmazeutischen Unternehmen, Phase 2 – Praktische Implementierung gemeinsamer Qualitäts-, Sicherheits- und Umweltschutzaudits, Pharm.Ind. 67 (11), 1277-1281, 2005

(207)Rank, F., Steven, W., Scheuermann, H.-J., Wozniewski, T., Müller, R. H., Mangement Tools for the Evaluation of Compliance and Costs in the Production of Chemical-Pharmaceutical Companies, Quality Assurance Journal 9 (3), 186-191, 2005

(208)Souto, E. B., Müller, R. H., The use of SLN and NLC as topical particulate carriers for imidazole anifungal agents, Die Pharmazie 61, 431-437, 2006

(209)Weyhers, H., Ehlers, S., Hahn, H., Souto, E. B., Müller, R. H., Solid lipid nanoparticles (SLN) – effects of lipid composition on in vitro degradation and in vivo toxicity, Die Pharmazie 61, 539-544, 2006

(210)Lemarchand, C., Gref, R., Passirani, C., Garcion, E., Petri, B., Müller, R. H., Costantini, D., Couvreur, P., Influence of polysaccharide coating on the interactions of nanoparticles with biological systems, Biomaterials 27 (1), 108-118, 2006

(211)Müller, R. H., Runge, S., Ravelli, V., Mehnert, M., Thünemann, A. F., Souto, E. B., Oral bioavailability of cyclosporine: solid lipid nanoparticles (SLN) versus drug nanocrystals, Int. J. Pharm. 317, 82-89, 2006

(212)Möschwitzer, J., Müller, R. H., New method for the effective production of ultrafine drug nanocrystals, Journal of Nanoscience and Nanotechnology 6, 3145-3153, 2006

(213)Weyhers, H. Löbenberg, R., Mehnert, W., Souto, E. B., Kreuter, J., Müller, R. H., In vivo distribution of ¹²⁵l-radiolabelled Solid Lipid Nanoparticles (SLN), Pharm.Ind. 68 (7), 889-894, 2006

(214)Lai, F., Wissing, S. A., Müller, R. H., Fadda, A. M., Artemisia arborescens L essential oil-loaded solid lipid nanoparticles for potential agricultural application: preparation and characterisation, AAPS PharmSciTech z, 2006

(215)Souto, E. B., Mehnert, W., Müller, R. H., Polymorphic behaviour of Compritol 888ATO as bulk lipid and as SLN and NLC, Journal of Microencapsulation 23 (4), 417-433, 2006

(216)Keck, C. M., Müller, R. H., Drug nanocrystals (DissoCubes, Nanopure) of poorly soluble drugs produced by high pressure homogenisation, Eur. J. Pharm. Biopharm. 62, 3-16, 2006

(217)Souto, E. B., Müller, R. H., Investigation of the factors influencing the incorporation of clotrimazole in SLN and NLC prepared by hot high-pressure homogenisation, Journal of Microencapsulation 23 (4), 377-388, 2006

(218)Möschwitzer, J., Müller, R. H., Spray coated pellets as carrier system for mucoadhesive drug nanocrystals, Eur. J. Pharm. Biopharm. 62, 282-287, 2006

(219)Souto, E. B., Müller, R. H., Gohla, S., A novel approach based on lipid nanoparticles (SLN) for topical delivery of α-lipoic acid, Journal of Microencapsulation 22 (6), 581-592, 2006

(220)Souto, E. B., Müller, R. H., Applications of Lipid Nanoparticles (SLN and NLC) in Food Industry, Journal of Food Technology 4 (1), 90-95, 2006

(221)Geßner, A., Paulke, B.-R., Müller, R. H., T. M. Göppert, Protein rejecting properties of PEG-grafted nanoparticles: Influence of PEG-chain length and surface density evaluated by two-dimensional electrophoresis and bicinchoninic acid (BCA)-proteinassay, Die Pharmazie 61, 293-297, 2006

(222)Radomska-Soukharev, A., Müller, R. H., Chemical stability of lipid excipients in SLN – production of test formulations, characterisation and short-term stability, Die Pharmazie 61, 425-430, 2006

(223)Cengiz, E., Wissing, S. A., Müller, R. H., Yazan, Y., Sunblocking efficiency of various TiO2-loaded solid lipid nanoparticle formulations, International Journal of Cosmetic Science, 28, 371-378, 2006

(224)Krickau, D. P., Müller, R. H., Thomsen, J., Degradation kinetics of hydrolytically susceptible drugs in o/w emulsions – effects of interfacial area and lecithin, Int. J. Pharm. 342, 62-71, 2007

(225)Teeranachaideekul, V., Souto, E. B., Junyaprasert, V. B., Müller, R. H., Cetylpalmitate-based NLC for topical delivery of coenzyme Q10 – development, physicochemical characterization and in vitro release studies, Eur. J. Pharm. Biopharm. 67, 141-148, 2007

(226)Petri, B., Bootz, A., Khalansky, A., Hekmatara, T., Müller, R. H., Uhl, R., Kreuter, J., Gelperina, S., Chemotherapy of brain tumour using doxorubicin bound to surfactant-coated poly (butyl cyanoacrylate) nanoparticles: revisiting the role of surfactants, J. Control. Rel. 117, 51-58, 2007

(227)Müller, R. H., Petersen, R. D., Hommoss, A., Pardeike, J., Nanostructured Lipid Carriers (NLC) in Cosmetic Dermal Products, Advanced Drug Delivery Reviews (ADDR) 59, 522-530, 2007

(228)Walzer, A., Tiemann, F., Knäblein, J., Gerbling, K.-P., Müller, R. H., Bunte, T., Rapid diagnostic method for quantitative testing of < 100 microbes in water, Journal of Pharmaceutical Science & Technology 61 (5), 411-420, 2007

(229)Teeranachaideekul, V., Müller, R. H., Junyaprasert, V. B., Encapsulation of ascorbyl palmitate in nanostructured lipid carriers (NLC) – Effects of formulation parameters on physiochemical stability, In. J. Pharm. 340, 198-206, 2007

(230)Xia, Q., Saupe, A., Souto, E. B., Müller, R. H., Nanostructured lipid carriers (NLC) as a novel carrier for sunscreen formulations, Int. J. Cosmet. Sci. 29, 473-482, 2007

(231)Müller, R. H., Lipid nanoparticles: recent advances, Advanced Drug Delivery Reviews (ADDR) 59, 375-376, 2007

(232)Walsh, G., Müller, R. H., The pharmaceutical biotechnology content of pharmacy programs within Europe: a survey, Journal of Science Education and Technology, Pharmacy Education 7 (1), 27-33, 2007

(233)Pardeike, J., Müller, R. H., Coenzyme Q10-loaded NLCs: preparation, occlusive properties and penetration enhancement, Pharmaceutical Technology Europe 19, 46-49, 2007

(234)Souto, E. B., Almeida, A. J., Müller, R. H., Lipid nanoparticles (SLN, NLC) for cutaneous drug delivery: structure, protection & skin effects, Journal of Biomedical Nanotechnology, 2007

(235)Souto, E. B., Müller, R. H., Rheological and in vitro release behaviour of clotrimazole-containing aqueous SLN dispersions and commercial creams, Die Pharmazie 62, 505-509, 2007

(236)Keck, C. M., Hommoss, A. H., Müller, R. H., Lipid nanoparticles for encapsulation of actives: dermal & oral formulations, American Pharmaceutical Review, 2007

(237)Souto, E. B., Müller, R. H., Almeida, J. A., Topical delivery of oily actives using solid lipid particles, Pharmaceutical Technology Europe 19 (12), 2007

(238)Junghanns, J.-U., Buttle, I., Müller, R. H., Araújo, I. B., Silva, A. K. A., Egito, E. S. T., Damasceno, B. P. G. L., SolEmuls technology: A way to overcome the drawback of parenteral administration of insoluble drugs, Pharmaceutical Development and Technology 12 (5), 437-445, 2007

(239)Keck, C. M., Müller, R. H., Size analysis of submicron particles by laser diffractometry – 90 % of the published measurements are false, Int. J. Pharm. 355, 150-163, 2008

(240)Teeranachaideekul, V., Junyaprasert, V. B., Souto, E. B., Müller, R. H., Development of ascorbyl palmitate nanocrystals applying the nanosuspension technology, Int. J. Pharm. 354, 227-234, 2008

(241)Junghanns, J.-U., Müller, R. H., Nanocrystal technology, drug delivery and clinical applications, International Journal of Nanomedicine, Vol. 3, 2008

(242)Gramdorf, S., Hermann, S., Hentschel, A., Schrader, K., Müller, R. H., Kumpugdee-Vollrath, M., Kraume, M., Crystallized miniemulsions: influence of operating parameters during high pressure homogenization on size and shape of particles, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 108-113, 2008

(243)Zietze, S., Müller, R. H., Brecht, R., Standardization, evaluation and early-phase method validation of an analytical scheme for batch-consistency N-glycosylation analysis of recombinant produced glycoproteins, Eur. J. Pharm. Biopharm. 68, 818-827, 2008

(244)Müller, R. H., Runge, S. A., Ravelli, V., Thünemann, A. F., Mehnert, W., Souto, E. B., Cyclosporine-loaded solid lipid nanoparticles (SLN): characterization of drug incorporation, Eur. J. Pharm. Biopharm. 68, 535-544, 2008

(245)Souto, E. B., Müller, R. H., Cosmetic features and applications of lipid nanoparticles (SLN, NLC) Int. J. Cosmet. Sci. 30, 157-165, 2008

(246)Müller, R. H., Maincent, P., Muchow, M., Lipid Nanoparticles with a solid matrix (SLN®, NLC®, LDC®) for oral drug delivery, Drug Development and Industrial Pharmacy 34, 1394-1405, 2008

(247)Keck, C., Kobierski, S., Mauludin, R., Müller, R. H., Second generation of drug nanocrystals for delivery of poorly soluble drugs: smartCrystals technology, Dosis 2, 126-130, 2008

(248)Hentschel, A., Gramdorf, S., Müller, R. H., Kurz, T., β-Carotene loaded nanostructured lipid carriers, Journal of Food Science 73 (2), N1-N6, 2008

(249)Pardeike, J., Hommoss, A., Müller, R. H., Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products, Int. J. Pharm. 366, 170-184, 2009

(250)Mauludin, R., Müller, R. H., Keck, C. M., Kinetic solubility and dissolution velocity of rutin nanocrystals, Eur. J. of Pharm. Sciences 36, 502-510, 2009

(251)Joshi, M., Müller, R. H., Lipid nanoparticles for parenteral delivery of actives, Eur. J. Pharm. Biopharm. 71, 161-172, 2009

(252)Mishra, P. R., Al Shaal, L., Müller, R. H., Keck, C. M., Production and characterization of Hesperitin nanosuspensions for dermal delivery, Int. J. Pharm. 371, 182-189, 2009

(253)Wang, Q, Sun, A. Y., Pardeike, J., Müller, R. H:, Simonyi, A., Sun, G. Y., Neuroprotective effects of a nanocrystal formulation of sPLA₂ inhibitor PX-18 in cerebral ischemia/reperfusion in gerbils, Brain Research 1285, 188-195, 2009

(254)Shubar, H. M., Dunay, I. R., Lachenmaier, S., Dathe, M., Bushrab, N. F., Mauludin, R., Müller, R. H., Fitzner, R., Borner, K., Liesenfeld, O., The role of apolipoprotein E in uptake of atovaquone into the brain in murine acute and reactivated toxoplasmosis, Journal of Drug Targeting 17 (4), 257-267, 2009

(255)Kobierski, S., Ofori-Kwakye, K., Müller, R. H., Keck, C. M., Resveratrol nanosuspensions for dermal application – production, characterisation & physical stability, Journal of Pharmacy and Pharmacology, Die Pharmazie 64, 741-747, 2009

(256)Mauludin, R., Müller, R. H., Keck, C. M., Development of an oral rutin nanocrystal formulation, Int. J. Pharm. 370, 202-209, 2009

(257)Domoki, F., Zimmermann, A., Lenti, L., Tóth-Szüki, V., Pardeike, J., Müller, R. H., Bari, F., Secretory phospholipase A2 inhibitor PX-18 preserves microvascular reactivity after cerebral ischemia in piglets, Microvascular Research 78, 212-217, 2009

(258)Pardeike, J., Müller, R. H., Dermal and ocular safety of the new phospholipase A₂ inhibitors PX-18 and PX-13 formulated as drug nanosuspension, Journal of Biomedical Nanotechnology 5, 437-444, 2009

(259)Junyaprasert, V. B., Teeranachaideekul, V. , Souto, E. B., Boonme, P. , Müller, R. H. , Q10-loaded NLC versus nanoemulsions: Stability, rheology and in vitro skin permeation, Int. J. Pharm. 377, 207-214, 2009

(260)Muchow, M., Schmitz, E. I., Despatova, N., Maincent, P., Müller, R. H., Omega-3 fatty acids-loaded lipid nanoparticles for patient-convenient oral bioavailability enhancement, Die Pharmazie 64 (8), 499-504

Non-refereed papers:

(1) Müller, R. H., Moderne Partikelmeßmethoden und ihre Anwendung in der Pharmazie, Teil 1: Mikroskopie und Weißlichtmessungen, Pharmazeutische Verfahrenstechnik heute 1, (12), 87-89, 1983

(2) Müller, R. H. , Moderne Partikelmeßmethoden und ihre Anwendung in der Pharmazie Teil 2: Meßverfahren unter Verwendung von Laserlicht, Pharmazeutische Verfahrenstechnik heute 1, (13), 91-94, 1983

(3) Müller, B. W. ,Müller, R. H., Bestimmung von mittleren Durchmessern und Größenverteilung an Teilchen im submikroskopischen Bereich mit der Photonenkorrelationsspektroskopie, Pharmazeutische Industrie 45, (11), 1150-1153, 1983

(4) Müller, R. H., Merz, J., Moderne Meßmethoden zur Bestimmung der Teilchenladung, Teil 1, Pharmazeutische Verfahrenstechnik heute 1, (20), 137-140, 1984

(5) Müller, R. H. und Merz, J., Moderne Meßmethoden zur Bestimmung der Teilchenladung, Teil 2, Pharmazeutische Verfahrenstechnik heute 1, (21), 141-144, 1985

(6) Müller, R. H., Heinemann, S., Drug Targeting. Kolloide Carrier zur intravenösen Applikation - Wunschtraum oder realistische Chance?, Deutsche Apotheker Zeitung 129 (41), 2188-2193, 1989

(7) Müller, B. W., Lucks, J. S., Stampa, B. und Müller, R. H., Effect of Anti-flocculants on Suspension Stability and Size Distribution - An investigation by laser light scattering techniques, Pharm. Ind. 52 (6), 789-793, 1990

(8) Müller, R. H., Heinemann, S., Smal, R., Stabilitätsbestimmung von Fettemulsionen zur parenteralen Ernährung, Deutsche Apotheker Zeitung 130 (6), 282-284, 1990

(9) Müller, R. H., Heinemann, S., Smal, R., Bestimmung der Organverteilung von Arzneiformen und Wirkstoffen durch Gamma-Szintigraphie, Deutsche Apotheker Zeitung 130 (8), 404-406, 1990

(10) Müller, R. H., Herbort, J., Lherm, C., Couvreur, P., Nanopartikel: Gewebsspezifische Arzneiform für Zytostatika, Deutsche Apotheker Zeitung 130 (27), 1509-1511, 1990

(11) Müller, R. H., Herbort, J., Smal, R., Heinemann, S., Latices: Polymerpartikel für Forschung und Arzneimittelherstellung, Deutsche Apotheker Zeitung 130 (21), 1210-1211, 1990

(12) Bräuer, A., Müller, R. H., Zellkulturen: Hepatozyten als In-vitro-Testsystem, Deutsche Apotheker Zeitung 130 (25), 1404-1405, 1990

(13) Müller, R. H., Herbort, J., Couvreur, P., Chiannilkulchai, N., Optimierung von Zytostatika-Formulierungen, Deutsche Apotheker Zeitung 131 (36), 1836-1837, 1991

(14) Müller, R. H., Waßmus, W., Smal, R., Koosha, F., Mikropartikel: Mikrodepots zur kontrollierten Arzneistoffabgabe, Deutsche Apotheker Zeitung 131 (40), 2049-2051, 1991

(15) Rudt, S., Smal, R., Müller, R. H., Chemilumineszenz-Assay: Untersuchung der Phagozytose von Arzneistoffträgern, Deutsche Apotheker Zeitung 132 (1/2), 10-11, 1992

(16) Rudt, S., Blunk, T., Müller, R. H., Quantification of Cell Subpopulations, Fractions of Dead Cells and Debris in Cell Suspensions by Laser Diffractometry, Pharm. Ind. 54 (11), 966-969, 1992

(17)